Results 1 to 10 of about 152,273 (295)

CD25-Targeted Aptamer–Drug Conjugate for the Treatment of CD25-Expressing Hematological Malignancies [PDF]

Pharmaceutics
Background: CD25, the α-chain of the interleukin-2 (IL-2) receptor, is highly expressed on malignant cells and tumor-infiltrating regulatory T-cells (Tregs) in hematologic malignancies, making it an attractive therapeutic target for tumor elimination and
Sanghyeok Woo, Ju-Hyung Kang, Inu Song, Soryong Lim, Hwarim Ryu, Yujin Lee, Daekyun Lee   +6 more
doaj   +2 more sources

Depletion of CD25+ cells restores Th1, Th2 and Th17 responses and mitigates Eimeria maxima infection in chickens [PDF]

Poultry Science
Chicken coccidia can suppress the host immune response through CD4+CD25+ T cells, compromising the effectiveness of immune prophylaxis and potentially leading to immune failure. However, the role of chicken CD4+CD25+ T cells in chicken coccidia infection
Yangdong Pan, Xianglin Pu, Yifan Zhang, Quanjia Xiang, Mingmin Lu, Lixin Xu, Ruofeng Yan, Xiangrui Li, Xiaokai Song   +8 more
doaj   +2 more sources

Expression of CD25 fluctuates in the leukemia-initiating cell population of CD25-positive AML.

PLoS ONE, 2018
CD25 is expressed on leukemic cells in 10-20% cases of acute myeloid leukemia (AML), and its expression is associated with poor prognosis. We reevaluated the relationship between CD25 expression and the leukemia-initiating cell (LIC) properties of AML ...
Yuki Kageyama, Hiroshi Miwa, Rino Arakawa, Isao Tawara, Kohshi Ohishi, Masahiro Masuya, Kazunori Nakase, Naoyuki Katayama   +7 more
doaj   +4 more sources

CD25+ B-1a Cells Express Aicda [PDF]

Frontiers in Immunology, 2017
B-1a cells are innate-like B-lymphocytes producing natural antibodies. Activation-induced cytidine deaminase (AID), a product of the Aicda gene, plays a central role in class-switch recombination and somatic hypermutation in B cells.
Hiroaki Kaku, Nichol E. Holodick, Joseph R. Tumang, Thomas L. Rothstein, Thomas L. Rothstein, Thomas L. Rothstein   +5 more
doaj   +3 more sources

CD4+CD25+ Immunoregulatory T Cells [PDF]

Immunity, 2002
CD4+CD25+ immunoregulatory T cells play a pivotal role in preventing organ-specific autoimmune diseases and in tolerance induction to allogeneic organ transplants. We investigated whether these cells could also control graft-versus-host disease (GVHD), the main complication after allogeneic hematopoietic stem cell transplantation (HSCT).
Ethan M Shevach
exaly   +2 more sources

Tumor site immune markers associated with risk for subsequent basal cell carcinomas. [PDF]

, 2011
BackgroundBasal cell carcinoma (BCC) tumors are the most common skin cancer and are highly immunogenic.ObjectiveThe goal of this study was to assess how immune-cell related gene expression in an initial BCC tumor biopsy was related to the appearance of ...
Andridge, Rebecca, Bechtel, Mark A, Chen, Min, De Renne, Lawrence A, Di Gregorio, Michael, Glaser, Ronald, Hearne, Dean W, Herron, Joel Bain, Jewell, Scott D, Johnson, Sheri L, Kiecolt-Glaser, Janice K, Lambert, David R, Shana'ah, Arwa Y, Yang, Eric V   +13 more
core   +21 more sources

Correlation of regulatory T cells in chronic lymphocytic leukemia characterized by high-affinity CD25 expression with serum IL-2 values, IGVH mutational status, Rai stage, and therapeutic lines [PDF]

Romanian Medical Journal, 2020
The impact of the importance of regulatory T cells (Treg) in chronic lymphocytic leukemia (CLL) is still controversial and no consensus has been reached on whether the effects generated by these cells are positive or negative in terms of tumor ...
Georgiana Ene, Ion Dumitru, Horia Bumbea, Minodora Onisâi, Ana-Maria Vlădăreanu   +4 more
doaj   +1 more source

IL-2/CD25 axis mediates cellular networks promoting the growth of CD25+ acute myeloid leukemia cells

Leukemia Research Reports
Although the expression of interleukin-2 receptor α-chain (IL-2Rα, CD25) has been provided prognostic significance independent of known biomarkers in acute myeloid leukemia (AML), the functional role of CD25 molecule remains unknown.
Kazunori Nakase, Kenkichi Kita
doaj   +3 more sources

Common Ɣ-chain cytokine receptors as functional phenotype markers of PD-1and TIM-3-positive T cells in multiple myeloma

Сибирский онкологический журнал, 2023
T cells expressing checkpoint receptors PD-1, TIM-3 etc., are potential targets for monoclonal antibody immunotherapy in multiple myeloma (MM). However, checkpoint expressing T cell compartment includes different subsets, and their dysregulation ...
E. V. Batorov, V. A. Aristova, G. Yu. Ushakova, S. A. Sizikova, V. V. Denisova, E. Ya. Shevela, A. A. Ostanin, E. R. Chernykh   +7 more
doaj   +1 more source

Natural T Regulatory Cells (n Treg) in the Peripheral Blood of Healthy Subjects and Subjects with Chronic Periodontitis – A Pilot Study [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: The T cells play a central role in the aetiopathogenesis of periodontal disease. Natural T regulatory cells (nTreg) are the key stone immunoregulatory elements having an anergic phenotype and play an important role in the suppression of
Ram Sabarish, Suresh Ranga Rao, Vamsi Lavu   +2 more
doaj   +1 more source