Results 11 to 20 of about 152,273 (295)

Cysteine-specific 89Zr-labeled anti-CD25 IgG allows immuno-PET imaging of interleukin-2 receptor-α on T cell lymphomas

Frontiers in Immunology, 2022
IntroductionPositron emission tomography (PET) using radiolabeled Abs as imaging tracer is called immuno-PET. Immuno-PET can verify therapeutic Ab delivery and can noninvasively quantify global levels of target expression in tumors of living subjects ...
Jin Hee Lee, Jin Hee Lee, Kyung-Ho Jung, Kyung-Ho Jung, Mina Kim, Mina Kim, Kyung-Han Lee, Kyung-Han Lee   +7 more
doaj   +1 more source

Regulation of T cell differentiation by the AP-1 transcription factor JunB

Immunological Medicine, 2021
JunB, a component of the activator protein-1 (AP-1) transcription factor, is known to exhibit an important role in bone formation and bone marrow cell proliferation. During T helper type 2 (Th2) cell differentiation, JunB contributes to the regulation of
Takaharu Katagiri, Hideto Kameda, Hiroyasu Nakano, Soh Yamazaki   +3 more
doaj   +1 more source

Transcriptomic profiling of tumor-infiltrating CD4 + TIM-3 + T Cells reveals their suppressive, exhausted, and metastatic characteristics in colorectal cancer patients [PDF]

, 2020
T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME).
Abu Nada, M, Ahmed, AA, Alajez, NM, Elkord, E, Kurer, MA, Murshed, K, Ouararhni, K, Sasidharan Nair, V, Soofi, ME, Taha, RZ, Toor, SM   +10 more
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CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion [PDF]

The Journal of Immunology, 2004
Abstract Naturally occurring CD4+ regulatory T cells are generally identified through their expression of CD25. However, in several experimental systems considerable Treg activity has been observed in the CD4+CD25− fraction. Upon adoptive transfer, the expression of CD25 in donor-derived cells is not stable, with CD4+CD25+ cells ...
Maria A, Curotto de Lafaille, Andreia C, Lino, Nino, Kutchukhidze, Juan J, Lafaille   +3 more
openaire   +2 more sources

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance [PDF]

The Journal of Immunology, 2002
AbstractCD4+CD25+ T cells have been proposed as the principal regulators of both self-tolerance and transplantation tolerance. Although CD4+CD25+ T cells do have a suppressive role in transplantation tolerance, so do CD4+CD25− T cells, although 10-fold less potent.
Graca, L, Thompson, S, Lin, C, Adams, E, Cobbold, S, Waldmann, H   +5 more
openaire   +3 more sources

Tumor growth suppression by implantation of an anti-CD25 antibody-immobilized material near the tumor via regulatory T cell capture

Science and Technology of Advanced Materials, 2021
In this study, we designed and synthesized an implantable anti-CD25 antibody-immobilized polyethylene (CD25-PE) mesh to suppress tumor growth by removing regulatory T cells (Tregs).
Tsuyoshi Kimura, Rino Tokunaga, Yoshihide Hashimoto, Naoko Nakamura, Akio Kishida   +4 more
doaj   +1 more source

Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis [PDF]

, 2018
Indexación: Scopus.Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring.
Albornoz, E., Binzberger, R., Bueno, S.M., Bugueño, K., Cabello-Verrugio, C., Elorza, A.A., Haensgen, H., Jara Fernández, E.L., Kalergis, A.M., Opazo, M.C., Riedel, C.A., Rivero-Castillo, T., Simon, F., Venegas Salas, L.F.   +13 more
core   +2 more sources

Difference between CD25+Tregs and Helios+Tregs in a murine model of allergic rhinitis

Brazilian Journal of Otorhinolaryngology, 2021
Introduction: Regulatory T or Treg cells, balance the peripheral immune response to allergens in allergic rhinitis. Traditionally, Treg (CD25+ Treg) is identified by the coexpression of Foxp3 and CD25, but this strategy does not represent the true ...
Yun-Xiu Wang, Zhao-Wei Gu, Zhi-Wei Cao
doaj   +1 more source

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo [PDF]

, 2015
Objective: Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in inflammatory bowel diseases. We aimed to analyze the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via ...
Agace, Alastair Watson, Anika Fischer, Atreya, Babyatsky, Baumgart, Canavan, Caroline Voskens, Christoph Becker, Clemens Neufert, Danese, Desreumaux, Dustin, Egawa, Fantini, Feagan, Fuss, Gerlach, Gerold Schuler, Ghosh, Haddad, Hamann, Hesterberg, Hoshino, Imke Atreya, Jovani, Kanai, Kempster, Kim, Ley, Li, Macdonald, Markus F Neurath, Matsuzaki, Maul, Neurath, Neurath, Nguyen, Nourshargh, Oki, Papadakis, Picarella, Podolsky, Pryde, Raja Atreya, Rocío López-Posadas, Rott, Rutgeerts, Sandborn, Sandborn, Sebastian Zundler, Shultz, Simon Hirschmann, Strober, Thomas, Tidswell, Timo Rath, Van Assche, Vermeire, Villablanca, Wang, Weninger, Wirtz, Wyant, Wyant   +64 more
core   +1 more source

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
core   +1 more source