Results 221 to 230 of about 152,273 (295)

Perp Deficiency Induces Defective Negative Selection and Autoimmune Arthritis in Aged Mice [PDF]

Aging Cell
Perp deficiency promotes age‐related autoimmunity. ABSTRACT Thymic negative selection is characterized by the apoptosis of autoreactive thymocytes and plays a critical role in maintaining self‐tolerance. Numerous apoptosis‐related genes influence cell fate during T‐cell development.
Zhou Y, Li J, Leng X, Shi J, Zhang G, Chen S, Liu D, Deng Q, He Y, Shi G, Xu Y, Liu Y, Wang Y.   +12 more
europepmc   +2 more sources

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

Disruption of metabolic licensing by JAK inhibitors constrains CD8 T cell activation and effector function. [PDF]

Cell Death Dis
Onofrio LI, Abrate C, Strusberg I, Morales L, Ceschin DG, Montes CL, Stempin CC, Acosta Rodríguez E.   +7 more
europepmc   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, Volume 600, Issue 8, Page 1222-1236, April 2026.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Hypobaric hypoxia can lead to an increase in lung dendritic cells and promote T-cell immunosuppression, thereby preventing the excessive progression of high-altitude pulmonary edema. [PDF]

Front Immunol
Wei X, Shi W, Dong X, Kong W, Dong L, Zhang L, Maimaitituerxun A, Hou C, Li D, Liu J, Ma X.   +10 more
europepmc   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, Volume 600, Issue 8, Page 1137-1150, April 2026.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Dynamic immune reconstitution and clinical outcomes in different chimerism statuses of HLA-matched transplantation for severe aplastic anemia. [PDF]

Stem Cells Transl Med
Lin MH, Xu ZL, Chang YJ, Guo HD, Xu LP, Wang Y, Zhang XH, Cheng YF, Zhang YY, Mo XD, Sun YQ, Han TT, Wang JZ, Chen Y, Chen YH, Chen H, Han W, Huang XJ.   +17 more
europepmc   +1 more source

GDNF‐RET signaling drives pulmonary neuroendocrine cell hyperplasia and allergic airway inflammation

FEBS Letters, Volume 600, Issue 8, Page 1185-1198, April 2026.
A neuroimmune interaction centered on the PNEC‐ILC2 axis in an asthma model. PNEC‐derived CGRP activates nearby ILC2s, which then release cytokines, including IL‐5 and IL‐13. These cytokines promote eosinophil and macrophage infiltration. Subsequently, GDNF produced by these cells induces PNEC hyperplasia via the GDNF receptors, RET and GFRα1 ...
Tasuku Kawano, Erina Ike, Suguru Okada, Tomoko Takahashi   +3 more
wiley   +1 more source

Identification of alterations of immunometabolism associated with Pompe disease. [PDF]

Cell Mol Life Sci
Costa-Verdera H, Gargaro M, Cagin U, Manni G, Scalisi G, Veron P, Silva Barcelos EC, Pieroni B, Mencarelli G, Ricciuti D, Nemazanyy I, Sanatine P, van Wittenberghe L, Laforêt P, Gross DA, Ronzitti G, Fallarino F, Mingozzi F.   +17 more
europepmc   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, Volume 13, Issue 4, Page 796-806, April 2026.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source