Results 1 to 10 of about 142,249 (285)
The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28 [PDF]
Frontiers in Immunology, 2021 Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the extracellular antigen-targeting CARs and the intracellular ...
Yannick D. Muller +28 more
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Journal of Research in Medical Sciences, 2021 Several studies have demonstrated that the genetic polymorphisms in the genes encoding immune regulatory molecules, namely cytotoxic T-lymphocyte-associated protein 4 (CTLA4) and CD28, play a fundamental role in susceptibility to rheumatoid arthritis (RA)
Mohammad Javad Mousavi +6 more
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OncoImmunology, 2022 CTLA4-CD28 gene fusion has been reported to occur in diverse types of T cell lymphoma. The fusion event is expected to convert inhibitory signals to activating signals and promote proliferation and potentially transformation of T cells.
Gyu Jin Lee +5 more
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Iraqi Journal of Hematology, 2023 BACKGROUND: Multiple myeloma is a clonal B-cell malignancy characterized by proliferation of plasma cells that secrete a complete and/or partial monoclonal immunoglobulin protein.
Zahraa Mahdi Sareeh +2 more
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SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling
eLife, 2022 T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of activated T cells.
Manuela Ecker +9 more
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Frontiers in Immunology, 2022 ObjectivesThis study aimed to elucidate the changes and associated mechanisms of circulating CD28- cytotoxic T lymphocytes (CTLs) in patients with IgG4-related disease (IgG4-RD).MethodsFifty IgG4-RD patients and 15 healthy controls (HCs) were recruited ...
Chang-sheng Xia +5 more
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Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4⁺ T cell responses. [PDF]
PLoS Pathogens, 2014 IL-13 driven Th2 immunity is indispensable for host protection against infection with the gastrointestinal nematode Nippostronglus brasiliensis. Disruption of CD28 mediated costimulation impairs development of adequate Th2 immunity, showing an importance
Hlumani Ndlovu +6 more
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Serum antibodies against CD28-- a new potential marker of dismal prognosis in melanoma patients. [PDF]
PLoS ONE, 2013 BACKGROUND: Autoantibodies against CD28 have been found in patients with autoimmune and atopic diseases. These antibodies may act as superagonists and activate T cells but may also be antagonistic or induce immunosuppressive effects by activating ...
Rebecca Körner +12 more
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Increased Neopterin Concentration in Older Age Coincides with Decline of CD28+CD45RA+ T-cells
Pteridines, 2004 Neopterin is produced from human monocyte-derived macrophages and dendritic cells upon Stimulation with interferon-y, and increased neopterin concentrations thus indicate cell-mediated immune activation.
Murr Christian +7 more
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BELATACEPT IN RENAL TRANSPLANTATION
Вестник трансплантологии и искусственных органов, 2013 Belatacept is a novel immunosuppressive agent that inhibits T-cell activation by blocking CD28 signaling pa- thway. It was developed based on abatacept (CTLA-4Ig), the first recombinant immunoglobulin fusion protein which contains extracellular part of ...
A. I. Sushkov, Y. G. Moysyuk
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