Results 21 to 30 of about 142,249 (285)

Human natural killer cell committed thymocytes and their relation to the T cell lineage. [PDF]

, 1993
Recent studies have demonstrated that mature natural killer (NK) cells can be grown from human triple negative (TN; CD3-, CD4-, CD8-) thymocytes, suggesting that a common NK/T cell precursor exists within the thymus that can give rise to both NK cells ...
Lanier, LL, Phillips, JH, Spits, H, Sánchez, MJ   +3 more
core   +1 more source

A CLDN18.2-Targeting Bispecific T Cell Co-Stimulatory Activator for Cancer Immunotherapy

Cancer Management and Research, 2021
Jie Liang,1 Huihui Zhang,1 Yue Huang,1 Lilv Fan,1 Fanlin Li,1 Min Li,1 Yaping Yan,1 Junshi Zhang,1 Zeyu Li,1 Xuanming Yang1,2 1Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University ...
Liang J, Zhang H, Huang Y, Fan L, Li F, Li M, Yan Y, Zhang J, Li Z, Yang X   +9 more
doaj  

Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. [PDF]

, 2017
The expansion of CD8+CD28- T cells, a population of terminally differentiated memory T cells, is one of the most consistent immunological changes in humans during aging.
Fei, Mingjian, Gordon, David E, Hull, Philip A, Jeng, Mark Y, Johnson, Jeffrey, Kasler, Herb, Krogan, Nevan, Kwon, Hye-Sook, Ng, Che-Ping, Ott, Melanie, Tsou, Chia-Lin, Verdin, Eric   +11 more
core   +1 more source

The CD28 Transmembrane Domain Contains an Essential Dimerization Motif

Frontiers in Immunology, 2020
CD28 plays a critical role in regulating immune responses both by enhancing effector T cell activation and differentiation and controlling the development and function of regulatory T cells.
Scott A. Leddon, Margaret M. Fettis, Kristin Abramo, Ryan Kelly, David Oleksyn, Jim Miller   +5 more
doaj   +1 more source

Deoxynivalenol Affects Proliferation and Expression of Activation-Related Molecules in Major Porcine T-Cell Subsets

Toxins, 2019
The Fusarium mycotoxin deoxynivalenol (DON) contaminates animal feed worldwide. In vivo, DON modifies the cellular protein synthesis, thereby also affecting the immune system. However, the functional consequences of this are still ill-defined.
Eleni Vatzia, Alix Pierron, Armin Saalmüller, Elisabeth Mayer, Wilhelm Gerner   +4 more
doaj   +1 more source

Mitochondrial Priming by CD28 [PDF]

Cell, 2017
T cell receptor (TCR) signaling without CD28 can elicit primary effector T cells, but memory T cells generated during this process are anergic, failing to respond to secondary antigen exposure. We show that, upon T cell activation, CD28 transiently promotes expression of carnitine palmitoyltransferase 1a (Cpt1a), an enzyme that facilitates ...
Ramon I. Klein Geltink, David O’Sullivan, Mauro Corrado, Anna Bremser, Michael D. Buck, Joerg M. Buescher, Elke Firat, Xuekai Zhu, Gabriele Niedermann, George Caputa, Beth Kelly, Ursula Warthorst, Anne Rensing-Ehl, Ryan L. Kyle, Lana Vandersarren, Jonathan D. Curtis, Annette E. Patterson, Simon Lawless, Katarzyna Grzes, Jing Qiu, David E. Sanin, Oliver Kretz, Tobias B. Huber, Sophie Janssens, Bart N. Lambrecht, Angelika S. Rambold, Edward J. Pearce, Erika L. Pearce   +27 more
openaire   +4 more sources

The effect of sodium deoxyribonucleate with iron complex on the expression of surface markers of MT-4 cells infected with human immunodeficiency virus type 1 (HIV-1) (Retroviridae: Primate lentivirus group)

Вопросы вирусологии
Introduction. The persistence of immune dysfunction during therapy has serious consequences for the health of HIV-infected people. Therefore, an important direction is the search for drugs that can reduce the inflammatory potential of the immune system ...
Dmitry N. Nosik, Lyudmila B. Kalnina, Lyudmila M. Selimova, Ellie N. Kaplina   +3 more
doaj   +1 more source

Serum exosomes as predictors of clinical response to ipilimumab in metastatic melanoma

OncoImmunology, 2018
Immunotherapy is effective in metastatic melanoma (MM) but most studies failed in discovering a biomarker predictive of clinical response. Exosomes (Exo) from melanoma cells are detectable in sera of MM patients similarly to those produced by immune ...
Marco Tucci, Anna Passarelli, Francesco Mannavola, Luigia Stefania Stucci, Paolo Antonio Ascierto, Marilena Capone, Gabriele Madonna, Patrizia Lopalco, Francesco Silvestris   +8 more
doaj   +1 more source

THE ROLE OF PREGNANCY-SPECIFIC GLYCOPROTEIN IN REGULATION OF MOLECULAR GENETIC DIFFERENTIATION MECHANISMS OF IMMUNE MEMORY T CELLS

Медицинская иммунология, 2019
The role of pregnancy-specific β1-glycoprotein (PSG) in the regulation of molecular genetic factors determining the functional activity of naїve T cells and T cells of immune memory in vitro was studied.
M. B. Rayev, L. S. Litvinova, K. A. Yurova, O. G. Khaziakhmatova, V. P. Timganova, M. S. Bochkova, P. V. Khramtsov, S. A. Zamorina   +7 more
doaj   +1 more source

Human CD8+CD28− T suppressor cells expanded by common gamma chain (γc) cytokines retain steady allospecific suppressive capacity in vivo

BMC Immunology, 2020
Background CD8+CD28− T suppressor (Ts) cells play critical role in transplant tolerance. Our previous study has generated CD8+CD28− Ts cells in vitro which exert robust allospecific suppressive capacity in vitro.
Guihuan Liu, Yuming Yu, Fu Feng, Ping Zhu, Hua Zhang, Danni Zhang, Xiaoqiang Feng, Zedan Zhang, Yanjun Liu   +8 more
doaj   +1 more source