Results 31 to 40 of about 142,249 (285)

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

OncoImmunology, 2019
Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells.
Fiamma Salerno, Aurelie Guislain, Julian J. Freen-Van Heeren, Benoit P. Nicolet, Howard A. Young, Monika C. Wolkers   +5 more
doaj   +1 more source

Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells. [PDF]

PLoS ONE, 2011
CD28 costimulation is a critical event in the full activation of CD4(+) T cells that augments cytokine gene transcription, promotes cytokine mRNA stability, prevents induction of anergy, increases cellular metabolism, and increases cell survival. However,
Sujit V Janardhan, Kesavannair Praveen, Reinhard Marks, Thomas F Gajewski   +3 more
doaj   +1 more source

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. [PDF]

, 2016
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication.
Abdel-Mohsen, Mohamed, Burwitz, Benjamin J, Chew, Glen M, Clayton, Kiera L, Deeks, Steven G, Fujita, Tsuyoshi, Hammond, Katherine B, Hansen, Scott G, Hecht, Frederick M, Ishii, Naoto, Korman, Alan J, Liegler, Teri, Maurer, Mark, Mitchell, Brooks I, Ndhlovu, Lishomwa C, Ostrowski, Mario, Reed, Jason S, Sacha, Jonah B, Shikuma, Cecilia M, Webb, Gabriela M, Wu, Helen L   +20 more
core   +3 more sources

Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells

Molecular Therapy: Oncolytics, 2020
B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs).
Phuong Nguyen, Emmanuel Okeke, Michael Clay, Dalia Haydar, Julie Justice, Carla O’Reilly, Shondra Pruett-Miller, James Papizan, Jennifer Moore, Sheng Zhou, Robert Throm, Giedre Krenciute, Stephen Gottschalk, Christopher DeRenzo   +13 more
doaj   +1 more source

B cell activation and affinity discrimination by receptor segregation? [PDF]

, 2005
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Gruhn, T., Iber, D., Lipowsky, R., Maini, P. K.   +3 more
core   +1 more source

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo

Frontiers in Immunology, 2018
Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell recall responses, we adoptively transferred in vitro generated OT-II T
Daniela Langenhorst, Stephanie Haack, Selina Göb, Anna Uri, Fred Lühder, Bernard Vanhove, Bernard Vanhove, Bernard Vanhove, Thomas Hünig, Niklas Beyersdorf   +9 more
doaj   +1 more source

The Expression of CD28 and Its Synergism on the Immune Response of Flounder (Paralichthys olivaceus) to Thymus-Dependent Antigen

Frontiers in Immunology, 2021
CD28 is well known as a critical T-cell costimulatory receptor involved in T cell activation by binding to its ligands. In this study, CD28 was cloned, and its expression profiles were characterized in flounder (Paralichthys olivaceus); variations of ...
Jing Xing, Jing Xing, Wenjing Liu, Xiaoqian Tang, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan, Wenbin Zhan   +8 more
doaj   +1 more source

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory infiltrating immune cells.
Agathocleous, Alcedo, Aza-Blanc, Bai, Bellavia, Boyman, Brennan, Buckland, Chan, Cheng, Crompton, D'Acquisto, de la Roche, Decker, Dennler, Drakopoulou, El Andaloussi, Feske, Finetti, Furler, Furmanski, Furmanski, Gilmour, Hafezi-Moghadam, Hager-Theodorides, Hager-Theodorides, Hatayama, Huang, Hui, Huse, Ingham, Jiang, Kahn, Kasper, Kim, Kumabe, Lau, Le, Lee, Li, Lowrey, Marigo, Matise, Medyouf, Michel, Mo, Neumann, Nielsen, Outram, Park, Perry, Pola, Priatel, Priatel, Reynolds, Riobó, Rohatgi, Rowbotham, Rowbotham, Rowbotham, Sacedón, Sacedón, Sato, Seo, Shah, Shimizu, Smith, Smith-Garvin, Stewart, Thompson, Varjosalo, Wakelin, Yamane   +72 more
core   +5 more sources

Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis [PDF]

, 2018
Indexación: Scopus.Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring.
Albornoz, E., Binzberger, R., Bueno, S.M., Bugueño, K., Cabello-Verrugio, C., Elorza, A.A., Haensgen, H., Jara Fernández, E.L., Kalergis, A.M., Opazo, M.C., Riedel, C.A., Rivero-Castillo, T., Simon, F., Venegas Salas, L.F.   +13 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source