Results 61 to 70 of about 142,249 (285)

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells [PDF]

, 2010
The serine/threonine kinase LKB1 has a conserved role in Drosophila and nematodes to co-ordinate cell metabolism. During T lymphocyte development in the thymus, progenitors need to synchronize increased metabolism with the onset of proliferation and ...
Aifantis, Aifantis, Alessi, Azzam, Bonaccorsi, Borowski, Boudeau, Bozulic, Cantrell, Cantrell, Cantrell, Chang, Choi, Ciofani, Ciofani, de Pooter, Frauwirth, Goldstein, Hardie, Hardie, Hayday, Hemminki, Hezel, Hinton, Hurov, Hurov, Ji, Jones, Juntilla, Kelly, Koo, Laky, Lee, Liang, Lizcano, Mao, Mayer, Michie, Mirouse, Partanen, Rodewald, Sakamoto, Sanchez-Cespedes, Schmitt, Shaw, Shaw, Smith-Garvin, Takahama, Takahama, Tamas, Ylikorkala   +50 more
core   +5 more sources

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection

eLife, 2014
The co-stimulatory molecule CD28 is essential for activation of helper T cells. Despite this critical role, it is not known whether CD28 has functions in maintaining T cell responses following activation.
Michelle A Linterman, Alice E Denton, Devina P Divekar, Ilona Zvetkova, Leanne Kane, Cristina Ferreira, Marc Veldhoen, Simon Clare, Gordon Dougan, Marion Espéli, Kenneth GC Smith   +10 more
doaj   +1 more source

Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis [PDF]

Disease Markers, 2011
Objective:Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved in T cell presentation. The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas the soluble concentrations of CD28
Ledezma-Lozano, I. Y., Padilla-Martínez, J. J., Leyva-Torres, S. D., Parra-Rojas, I., Ramírez-Dueñas, M. G., Pereira-Suárez, Ana Laura, Rangel-Villalobos, H., Ruiz-Quezada, S. L., Sánchez-Hernández, P. E., Muñoz-Valle, J. F.   +9 more
openaire   +2 more sources

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. [PDF]

, 1995
Insulin-dependent diabetes mellitus (IDDM) is thought to be an immunologically mediated disease resulting in the complete destruction of the insulin-producing islets of Langerhans.
Bluestone, JA, Gray, G, Herold, KC, Ho, SC, Lenschow, DJ, Nabavi, N, Rhee, L, Sattar, H   +7 more
core  

A Human‐Based Skin‐Lymphoreticular Model‐on‐Chip to Emulate Inflammatory Skin Conditions

Advanced Healthcare Materials, EarlyView.
A human‐based lymphoreticular (LR) model was developed through guided self‐assembly and integrated in a skin‐lymphoreticular co‐culture in a microfluidic organ‐on‐chip to mimic interactions between skin and its draining lymph nodes. The human‐based skin‐lymphoreticular model resembles a minimally functional unit that allows to study interactions ...
Zheng Tan, Partho Protim Adhikary, Dana Wörz, Sarah Hedtrich   +3 more
wiley   +1 more source

The role of CD319, CD117, CD28, CD49e, CD56, and CD44 expression as diagnostic and prognostic markers in multiple myeloma

Iraqi Journal of Hematology
BACKGROUND: Multiple myeloma (MM) is a plasma cell disorder characterized by the infiltration of clonal plasma cells in the bone marrow and the detection of a monoclonal immunoglobulin in serum and/or urine.
May Ahmed Al-Ahmed, Haithem Ahmed Al-Rubaie   +1 more
doaj   +1 more source

Staphylococcal and Streptococcal Superantigens Trigger B7/CD28 Costimulatory Receptor Engagement to Hyperinduce Inflammatory Cytokines

Frontiers in Immunology, 2019
Staphylococcal and streptococcal superantigens are virulence factors that cause toxic shock by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction between the principal costimulatory receptor CD28 and its two coligands,
Andrey Popugailo, Ziv Rotfogel, Emmanuelle Supper, Dalia Hillman, Raymond Kaempfer   +4 more
doaj   +1 more source

Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice [PDF]

, 2016
Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Andreas J.R. Habenicht, Changjun Yin, Christian Weber, Coleen A. McNamara, Desheng Hu, Gianluca Grassia, Kulkarni U, Li Peng, Michael Beer, Pasquale Maffia, Prasad Srikakulapu, Rudolf A. Manz, Sai Vineela Bontha, Sarajo K. Mohanta   +13 more
core   +1 more source