Results 171 to 180 of about 228,118 (255)

The Anti‐Inflammatory Effect of Normothermic Machine Perfused Human Kidneys on Monocyte‐Derived Dendritic Cells

Artificial Organs, EarlyView.
The immunogenicity of donor kidneys on NMP can be studied using monocyte‐derived dendritic cells. Incubation with perfusate showed an anti‐inflammatory dendritic cell phenotype and function that suggests the release of an anti‐inflammatory factor or factors during NMP. ABSTRACT Background The immunomodulatory activity of normothermic machine perfusion (
Laura W. D. Knijff, Asel S. Arykbaeva, Sandra W. van der Kooij, Dorottya K. de Vries, Mieke F. van Essen, Ian P. J. Alwayn, Henri G. D. Leuvenink, Rutger J. Ploeg, Cees van Kooten   +8 more
wiley   +1 more source

Lenalidomide boosts CD1d-Vδ2 bispecific antibody-engaged Vγ9Vδ2-T cell effector functions via CD28, Notch signaling and IL-2 release. [PDF]

J Immunother Cancer
de Jong M, Veth M, Brachtlová T, King LA, Saura-Esteller J, Bechler TM, van Helden PM, Alhan C, Lameris R, de Gruijl TD, van der Vliet HJ.   +10 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Exploring the landscape of programmed cell death protein-1 and cluster of differentiation 28 positive T cells and cytokines in non-small cell lung cancer: A retrospective case-control study. [PDF]

J Int Med Res
Yang Y, Li RC, Lyu C, Zhang W, Sun Y, Xie R.   +5 more
europepmc   +1 more source

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

An Overview on T-Cell Engagers: The Current Position in Both the Biological and Mathematical Context. [PDF]

Comput Struct Biotechnol J
Davies J, Brown LV, Jones MW, Penney M, Powathil G.   +4 more
europepmc   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Overcoming fratricide of CD86 targeting CAR-T cells by defined logic-gate CAR strategy. [PDF]

Exp Hematol Oncol
Riet T, Lennartz S, Bösing N, Prinz LF, Dähn L, Scheid C, Hallek M, Chmielewski MM.   +7 more
europepmc   +1 more source

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

From T cell engagers to next-generation immune cell engagers for cancer immunotherapy. [PDF]

Antib Ther
Yang Z, Fu YX.
europepmc   +1 more source