Results 191 to 200 of about 228,118 (255)

High ZFP36 Family Expression in Exhausted T Cells Is Associated With Impaired Antitumor Effector Function

Cancer Science, EarlyView.
Hypoxia induces ZFP36 family expression in exhausted CD8+ T cells, promoting the decay of AU‐rich effector cytokine mRNAs and suppressing TNF, IL2, and IFNG expression, thereby potentially contributing to impaired antitumor effector function. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by reinvigorating antitumor ...
Li Zhu, Youki Ueda, Yu Inutsuka, Toshifumi Ninomiya, Yuka Saeki, Takashi Inozume, Hiroko Watanabe, Takamasa Ishino, Hiroyoshi Y. Tanaka, Kazuo Yamashita, Masakiyo Sakaguchi, Joji Nagasaki, Yosuke Togashi   +12 more
wiley   +1 more source

Methodological Insights Into T-Cell Activation: CD3/CD28 Versus PMA/Ionomycin Stimulation. [PDF]

Eur J Immunol
Abdulhaqov N, Melo LTA, Meinert I, Fricke S, Simeoni L.   +4 more
europepmc   +1 more source

VEGF‐A Antisense Oligonucleotide Therapy Inhibits Corneal Neovascularisation and Enhances Graft Survival in Murine High‐Risk Corneal Transplantation

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To investigate, for the first time, whether an unconjugated VEGF‐A antisense oligonucleotide (ASO) can inhibit corneal neovascularisation and improve graft survival in a murine high‐risk corneal transplantation model. Methods A suture‐induced corneal neovascularisation model was established in BALB/c mice, followed by high‐risk ...
Wei Zhang, Christian Weile, Christoph Ullmer, Sascha Fauser, Felix Bock, Claus Cursiefen   +5 more
wiley   +1 more source

Optimization of hinge domain enhances antitumor efficacy of globo H-targeted CAR-T cells in solid tumor models. [PDF]

iScience
Li S, Xie H, Zhu Y, Tu J, Li X, Zhang G, He Y, Xing L, Lu Z, Xiong H, Zhang C.   +10 more
europepmc   +1 more source

InflaMix Predicts Severe CRS, ICU Admission, and Progression‐Free Survival After CAR‐T Therapy in LBCL

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Baseline systemic inflammation has emerged as a determinant of outcome after CD19‐directed CAR‐T therapy. We evaluated the prognostic performance of the recently developed INFLAmmation MIXture Model (InflaMix) in an independent bicentric cohort of patients with large B‐cell lymphoma (LBCL) receiving commercial CAR‐T cells, focusing ...
Eugenio Galli, Daniele Mannina, Alessandro Corrente, Chiara De Philippis, Ilaria Pansini, Marcello Viscovo, Stefan Hohaus, Patrizia Chiusolo, Federica Sorà, Stefania Bramanti, Simona Sica   +10 more
wiley   +1 more source

Analysis of peripheral blood T-cell levels for predicting immunotherapy response sensitivity in squamous cell carcinoma of the head and neck. [PDF]

Front Mol Biosci
Li N, Feng L, Yin G, Ding S, Guo W.
europepmc   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Agonistic bispecific antibodies: an emerging frontier in antibody therapeutics. [PDF]

J Transl Med
Yang J, Deng J, Sun Z, Liu Y, Wang Y, Meng X, Liu X, Ma X, Sun P.   +8 more
europepmc   +1 more source

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

Fluid shear stress as a co-stimulatory cue to enhance T cell priming and restore activation in cancer patient T cells. [PDF]

J Immunol
Sarna NS, Antunovic M, Hurley PJ, Schaffer KR, King MR.   +4 more
europepmc   +1 more source