Results 31 to 40 of about 304,036 (298)

In planta transient recombinant production of a bispecific T-cell engager: Blinatumomab [PDF]

Iran Agricultural Research
Bispecific T-cell engagers (BiTEs) are increasingly being recognized as promising therapeutic molecules in tumor management. However, these largely artificial and complex antibody-based molecules are often difficult to express in conventional platforms ...
Saeideh Dianatkhah, Hiremath Chaitra, Melnik Stanislav, Lin Sun, Amin Ramezani, Ali Niazi, Alireza Afsharifar, Ali Moghadam, Somanath Kallolimath   +8 more
doaj   +1 more source

Horizontal and vertical distribution of CD3+ lymphocytes in the intestine of healthy adult and neonatal dogs [PDF]

, 2017
T-lymphocytes are considered to play an essential role in the pathogenesis of inflammatory bowel disease. The goal of this study was an objective determination of the distribution of gastrointestinal CD3+ lymphocytes in a standardized dog population as a
Pfammatter, Nadia, Hartnack, S, Brunner, T, Luckschander, N, Jakob, S, Burgener, Iwan A   +5 more
core   +1 more source

Correlation between peripheral blood lymphocyte subpopulations and primary systemic lupus erythematosus

Open Life Sciences, 2022
This study explored the correlation between peripheral blood CD3＋, CD3＋/CD4＋, CD3+/CD8+, CD4＋/CD8＋, CD3−/CD16+ CD56+, and CD3−CD19+ and disease activity of different subtypes of systemic lupus erythematosus (SLE). The percentages of CD3+, CD3+/CD4+, CD3+/
Feng Yan, Li Zhijun, Xie Changhao, Lu Fanglin   +3 more
doaj   +1 more source

Immunological cluster complexes in kidney transplantation

Медицинская иммунология, 2022
Laboratory tests are significant for the detection of immunopathological disorders in kidney transplantation. As a rule, the choice of tests is carried out individually and is based on the clinical characteristics and the presumptive diagnosis.
S. V. Zybleva, S. L. Zyblev
doaj   +1 more source

TCRαβ/CD3 disruption enables CD3-specific antileukemic T cell immunotherapy [PDF]

, 2018
T cells engineered to express chimeric antigen receptors (CARs) against B cell antigens are being investigated as cellular immunotherapies. Similar approaches designed to target T cell malignancies have been hampered by the critical issue of T-on-T ...
Georgiadis, C, Preece, R, Mock, U, Qasim, W, Rasaiyaah, J   +4 more
core   +2 more sources

Acquired aberrant partial CD3 expression in recurrent Epstein-Barr virus–negative solitary plasmacytoma of tonsil [PDF]

Journal of Pathology and Translational Medicine
The aberrant expression of specific T-cell maker CD3 in B-cell neoplasms can be a potential diagnostic pitfall leading to a misclassification of cell lineage.
Chenchen Niu, Dong Ren, Truc Tran, Ashley Gamayo, Sherif Rezk, Xiaohui Zhao   +5 more
doaj   +1 more source

Overcoming resistance to HER2-targeted therapy with a novel HER2/CD3 bispecific antibody

OncoImmunology, 2017
T-cell-based therapies have emerged as one of the most clinically effective ways to target solid and non-solid tumors. HER2 is responsible for the oncogenesis and treatment resistance of several human solid tumors.
Andres Lopez-Albaitero, Hong Xu, Hongfen Guo, Linlin Wang, Zhihao Wu, Hoa Tran, Sarat Chandarlapaty, Maurizio Scaltriti, Yelena Janjigian, Elisa de Stanchina, Nai-Kong V. Cheung   +10 more
doaj   +1 more source

Toward Gene Therapy for Human CD3 Deficiencies

, 2003
The CD3 subunits of the T cell receptor-CD3 complex (TCR-CD3) help to regulate surface TCR-CD3 expression, and participate in signal transduction leading to intrathymic selection and peripheral antigen recognition by T lymphocytes.
A. Pacheco-Castro, Pacheco Castro, A., Martin-Fernandez, JM, Regueiro González-Barros, José Ramón, J.R. Regueiro, Millán, R., R. Millán, Sanal, O., Pacheco-Castro, A, Sanal, O, L. Allende, Regueiro, JR, Allende, L, J.M. Martín-Fernández, Millan, R, Allende Martínez, Luis Miguel, Martín Fernández, J.M., O. Sanal   +17 more
core   +1 more source

A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refractory solid tumors

OncoImmunology, 2018
We assessed the tolerability and antitumor activity of solitomab, a bispecific T-cell engager (BiTE®) antibody construct targeting epithelial cell adhesion molecule (EpCAM).
Maxim Kebenko, Marie-Elisabeth Goebeler, Martin Wolf, Annette Hasenburg, Ruth Seggewiss-Bernhardt, Barbara Ritter, Beate Rautenberg, Djordje Atanackovic, Andrea Kratzer, James B. Rottman, Matthias Friedrich, Eva Vieser, Stefanie Elm, Ingrid Patzak, Dorothea Wessiepe, Sabine Stienen, Walter Fiedler   +16 more
doaj   +1 more source

The pathophysiologic significance of lymphocyte subset determination in children with infectious mononucleosis, mycoplasma pneumonia and Henoch–Schönlein purpura

BMC Pediatrics, 2022
Objective This study aimed to explore lymphocyte subset determinations as an aid to understanding the pathophysiology of infectious mononucleosis (IM), pneumonia due to mycoplasma infection (P-MI) and Henoch–Schönlein purpura in children.
Liang Zhao, Hao Wang, Hua-Xing Wei, Yong Lv   +3 more
doaj   +1 more source