Results 41 to 50 of about 280,132 (264)

Residual Bone Marrow T & NK-Cells at Diagnosis in Pediatric Pre-B-ALL: A Case–Control Study

International Journal of General Medicine, 2022
Dalia Mahmoud Eldewi,1 Hanan A El‑Hagrasy,1 Rasha Mahmoud Gouda,2 Mohammed Abd El Malik Hassan,3 Shimaa Moustafa Kamel,2 Naglaa F Abd El Haliem,4 Haneya AA Anani4 1Department of Clinical Pathology - Faculty of Medicine (For Girls), Al‑Azhar University ...
Eldewi DM, El‑Hagrasy HA, Gouda RM, Hassan MAEM, Kamel SM, Abd El Haliem NF, Anani HAA   +6 more
doaj  

CD8+ T lymphocyte is a main source of interferon-gamma production in Takayasu’s arteritis

Scientific Reports, 2021
Interferon-gamma (IFN-γ) is a cytokine involved in the pathogenesis of Takayasu’s arteritis (TAK). However, the source of IFN-γ in TAK patients is not fully clear. We aimed to investigate the source of IFN-γ in TAK. 60 TAK patients and 35 health controls
Yan-Long Ren, Tao-Tao Li, Wei Cui, Li-Min Zhao, Na Gao, Hua Liao, Jiang-Hui Zhang, Jun-Ming Zhu, Zhi-Yu Qiao, Shi-Chao Guo, Li-Li Pan   +10 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential Biological Role Of Cd3 Chains Revealed By Human Immunodeficiencies

, 2007
The biological role in vivo of the homologous CD3 gamma and delta invariant chains within the human TCR/CD3 complex is a matter of debate, as murine models do not recapitulate human immunodeficiencies.
Moreno-Pelayo, Miguel Angel, Modamio-Hoybjor, Silvia, Regueiro González-Barros, José Ramón, Recio, Maria J., Guardo, Alberto C., Kılıç, Sara S., Kilic, Sara S., Allende, Luis M., Moreno Pelayo, Miguel Angel, Pérez Flores, Verónica, Modamio Høybjør, Silvia, Kiliç, Sara, Recio Hoyas, María José, Perez-Flores, Veronica, Regueiro, Jose R., Allende Martínez, Luis Miguel, Sanal, Ozden, Mencia, Angeles, Seoane, Elena   +18 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Expression and function of a variant T cell receptor complex lacking CD3-gamma.

, 1991
A T cell line termed DIL2 has been derived from an infant with a polyclonal T cell receptor (TCR)/CD3 cell surface expression defect. Indirect immunofluorescence showed that the expression of certain TCR/CD3 epitopes (like those detected by WT31 and ...
Regueiro González-Barros, José Ramón, Terhorst, Cox, Alarcon, Balbino, ArnaizVillena, Antonio, M Timón, P Pérez-Aciego, O G Segurado, B Alarcón, Timon, Marcos, Segurado, Oscar, A Arnaiz-Villena, J R Regueiro, C Terhorst, Perez Aciego, Paloma, Arnaiz Villena, Antonio   +14 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The percentages of CD3+, CD3+CD4+, CD3+CD8+in each group (M ± SD, n = 6, unit = %).

, 2018
The percentages of CD3+, CD3+CD4+, CD3+CD8+in each group (M ± SD, n = 6, unit = %).
Guizhou Yue (1419832), Gang Ye (318792), Qiuting Fu (4872349), Lixia Li (407712), Xu Song (420074), Yi Yang (116183), Jiankang Yu (4872337), Renyong Jia (420073), Qiankun Cui (4872340), Kai Sun (140584), Shufan Chen (3714010), Yuanfeng Zou (4872346), Xinghong Zhao (649658), Xiaoxia Liang (420078), Lu Bai (343118), Lizi Yin (4872343), Zhongqiong Yin (420071), Ye Tian (220278), Cheng Lv (420077), Changliang He (420079)   +19 more
core   +1 more source

CD3+ T-cell subsets and CD3+CD4+ T-cell responses to SARS-CoV-2 spike protein.

, 2022
(A) C3+CD4+ and CD3+CD4+ T-cell frequencies depicted per patient, MIS-C classification, ICU stay and age. (B) CD4+/CD8+ ratios in MIS-C and KD patients (C) CD4+/CD8+ ratios in relation to ICU stay (D) Representative flow cytometry contour plots of CD3 ...
T. H. M. Ottenhoff (9081397), D. van Stijn (14197476), D. Schonenberg-Meinema (7346594), I. M. Kuipers (14197470), G. Biesbroek (14197464), H. Scherpbier (14197512), E. G. J. von Asmuth (14197494), M. van der Kuip (14197491), M. H. A. Jansen (14197485), K. E. van Meijgaarden (14197515), J. M. van den Berg (14197536), H. L. Zaaijer (14197530), M. P. Gruppen (14197473), B. Kapitein (14197467), T. E. Peros (14197479), M. G. Mooij (14197497), N. Ketharanathan (14197521), M. Blink (14197524), P. Hombrink (14197533), G. W. Landman (14197503), M. Boele van Hensbroek (14197509), A. M. Tutu van Furth (14197506), M. E. J. den Boer (14197500), M. A. van Houten (11823314), S. A. Joosten (14197518), E. P. Buddingh (14197539), T. W. Kuijpers (7638836), M. van Veenendaal (14197482), C. L. H. Brackel (14197527), C. W. van der Zee (14197488)   +29 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source