Results 61 to 70 of about 304,036 (298)

Total Th1/Th2 cytokines profile from peripheral blood lymphocytes in normal pregnancy and preeclampsia syndrome

Hypertension in Pregnancy, 2022
To evaluate total Th1/Th2 cytokines in CD3+ cells (immunocompetent T-lymphocytes) and peripheral blood lymphocytes, mostly CD4+ (T helper cells) and CD8+ (T-cytotoxic cells) subpopulations in preeclampsia.
Iara dos Santos Fagundes, Eduardo Pletsch Brendler, Isadora Nunes Erthal, Raquel Jaqueline Eder Ribeiro, Rafaela Siviero Caron-Lienert, Denise Cantarelli Machado, Bartira Ercília Pinheiro da Costa, Carlos Eduardo Poli-de-Figueiredo   +7 more
doaj   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing

Virology Journal, 2007
Background HTLV-I infected CD4+ T-cells lines usually progress towards a CD3- or CD3low phenotype. In this paper, we studied expression, kinetics, chromatin remodeling of the CD3 gene at different time-points post HTLV-I infection.
Martiat Philippe, Burny Arsène, Merimi Makram, Moschitta Maria, Manfouo-Foutsop Germain, Dobirta Gratiela, Badran Bassam, Akl Haidar, Willard-Gallo Karen E   +8 more
doaj   +1 more source

Expansion of mixed immune cells using CD3/CD161 co-stimulation for the treatment of cancer

Scientific Reports, 2023
Adoptive cell transfer (ACT) is a type of personalized immunotherapy in which expanded immune cells are administered to patients with cancer. However, single-cell populations, such as killer T cells, dendritic cells, natural killer (NK) cells, and NKT ...
Ryo Tsumura, Miwa Haruta, Masataka Kuwano, Masahiro Yasunaga   +3 more
doaj   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

Nature Communications, 2018
Tumor cells can fuel their metabolism with lactate. Here the authors show that inhibition of mitochondrial pyruvate carrier (MPC) blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation and inhibits oxidative metabolism ...
Cyril Corbet, Estelle Bastien, Nihed Draoui, Bastien Doix, Lionel Mignion, Bénédicte F. Jordan, Arnaud Marchand, Jean-Christophe Vanherck, Patrick Chaltin, Olivier Schakman, Holger M. Becker, Olivier Riant, Olivier Feron   +12 more
doaj   +1 more source

Generation of CD3+ thymocytes.

, 2013
(A) CD7hiCD3hi and CD7 dim CD3⁻ cells were detected at day 7. (B) By day 12 approximately 90% of all the cells generated were CD3+ thymocytes. (C) A matrix seeded with approximately 300 CD34+ cord blood derived progenitors generated about 2900 CD3+ cells
Richard Aspinall (348825), Christopher B-Lynch (435973), Chrysa Kapeni (435974), Antonio Lapenna (435972)   +3 more
core   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Frequency of RORγt and T-bet expression in CD3⁺, CD3⁺CD4⁺, CD3⁺CD8⁺ lymphocytes.

, 2019
A-G. Expression of transcription factors RORγt and T-bet in CD3+, CD3+CD4+, and CD3+CD8+ Lymphocytes and in CD3+ Naive (N), Central Memory (CM), Effector Memory (EM), and Terminally Differentiated (TD) Cells. Co-expression of T-bet in CD3+, CD3+CD4+, and
Thomas Ryan (6196559), Brian O’Connell (1888420), Ana Moreno-Olivera (7553411), Alhanouf I. Al-Harbi (7553414), Derek G. Doherty (7553420), Ross McManus (23779), Eamon P. Breen (4583362), John D. Coakley (7553408), Ashanty M. Melo (7553417)   +8 more
core   +1 more source