Results 61 to 70 of about 280,132 (264)

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

open access: yesNature Communications, 2018
Tumor cells can fuel their metabolism with lactate. Here the authors show that inhibition of mitochondrial pyruvate carrier (MPC) blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation and inhibits oxidative metabolism ...
Cyril Corbet   +12 more
doaj   +1 more source

Expansion of mixed immune cells using CD3/CD161 co-stimulation for the treatment of cancer

open access: yesScientific Reports, 2023
Adoptive cell transfer (ACT) is a type of personalized immunotherapy in which expanded immune cells are administered to patients with cancer. However, single-cell populations, such as killer T cells, dendritic cells, natural killer (NK) cells, and NKT ...
Ryo Tsumura   +3 more
doaj   +1 more source

Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles

open access: yesAdvanced Materials, EarlyView.
This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen   +19 more
wiley   +1 more source

CD3 immunofluorescence in porcine conjunctiva.

open access: yes, 2020
Dotted line marks the limits of the same follicle shown in each of the panels. Dotted-dash lines mark the limit between conjunctival epithelium and stroma.
Mario Crespo-Moral (8292975)   +3 more
core   +1 more source

A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production

open access: yesAdvanced Materials Technologies, EarlyView.
Mesenchymal stem cell derived extracellular vesicles (MSC‐EVs) are a promising therapeutic tool for regenerative medicine. However, the field lacks a reproducible high‐yield production method to answer the quantities needed for clinical translation.
Christophe Wong   +7 more
wiley   +1 more source

Activated human T cells secrete exosomes that participate in IL-2 mediated immune response signaling. [PDF]

open access: yesPLoS ONE, 2012
It has previously been shown that nano-meter sized vesicles (30-100 nm), exosomes, secreted by antigen presenting cells can induce T cell responses thus showing the potential of exosomes to be used as immunological tools.
Jessica Wahlgren   +4 more
doaj   +1 more source

Zmiany ilościowe populacji limfocytów CD3+ i CD45RA+ we krwi szczurów poddanych działaniu wolnozmiennego pola elektromagnetycznego [PDF]

open access: yes, 2007
It was reported that an extremely low frequency (ELF) electromagnetic field causes biological effects in vitro and in vivo. The major functions of the immune system are to develop the concept of "self" and eliminate what is "non-self". In our preliminary
Salwiczek, Anna   +8 more
core  

Generation of CD3+ thymocytes.

open access: yes, 2013
(A) CD7hiCD3hi and CD7 dim CD3⁻ cells were detected at day 7. (B) By day 12 approximately 90% of all the cells generated were CD3+ thymocytes. (C) A matrix seeded with approximately 300 CD34+ cord blood derived progenitors generated about 2900 CD3+ cells
Richard Aspinall (348825)   +3 more
core   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

open access: yesAdvanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang   +10 more
wiley   +1 more source

Analysis of IFNG expression in CD3+ and CD3- cell subsets.

open access: yes, 2015
PBMC from LTBI+ donors were stimulated with PPD or left unstimulated, stained with antibodies against surface markers as indicated, probed with Cy5-labeled IFNG probes, and analyzed by flow cytometry.
Riccardo Arrigucci (836859)   +8 more
core   +1 more source

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