Results 51 to 60 of about 243,350 (258)

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Diagnostic significance of the determination of peripheral blood lymphocytes for predicting the onset of pregnancy in patients with repeated implant failures in groups with different protocols of the assisted reproductive technology program [PDF]

Гинекология, 2017
Purpose of the study. Study of the diagnostic significance of the determination of peripheral blood lymphocytes with phenotypes significantly different from the control values for predicting the onset of pregnancy in groups with different protocols of ...
T S Amyan, L V Krechetova, S G Perminova, V V Vtorushina, F N Selimova   +4 more
doaj  

CD3 ALDOSTERONISM, HEART AND VESSELS

Artery Research, 2015
It has been documented that absolute aldosterone excess in patients with primary aldosteronism (PA) has been associated with higher risk of heart, vascular and kidney damage independent on blood pressure and resulting in increased total cardiovascular ...
Aleksander Prejbisz
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Immune cells and tryptophan metabolism in the joint capsule tissue in rheumatoid arthritis

Acta Biomedica Scientifica
To the present day, many links in the pathogenesis of rheumatoid arthritis remain unclear, which leads to unsatisfactory results in its therapy.The aim.
E. A. Stepanov
doaj   +1 more source

The immunologic characteristic of the stages of chronic hepatitis C and an assessment of immune system factors as prognostic criteria of a current disease

Журнал инфектологии, 2014
In the present study factors of immune system in peripheral blood (PB) of patients with chronic hepatitis C (CHС) with the different degree of fibrosis were determined.
V. Yu. Nikitin, I. A. Sukhina, V. N. Tsigan, D. A. Gusev   +3 more
doaj   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Indicii imunității la pacienții cu tuberculoză pulmonară sub influența tratamentului complex

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
La 49 de pacienți cu tuberculoză pulmonară asociată cu toxocaroză, care au urmat tratament standard antituberculos, antiparazitar și imunocorectiv, a fost studiată dinamica indicilor răspunsului imun Th1 și Th2 și prezența corelației IL-5 cu eozinofilia ...
Angela Guila, Natalia Zincenco, Corina Rotaru-Lungu, Serghei Ghinda, Valentina Chiroşca, Elena Privalova   +5 more
doaj  

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Pathomorphological brain changes due to coronavirus disease 2019 (COVID-19)

Patologìâ
Aim: To investigate the pathomorphological changes in the brains of individuals who died from complications of coronavirus disease (COVID-19) and to identify the neuropathological features associated with COVID-19. Materials and methods.
L. I. Volos, H. L. Stoliar
doaj   +1 more source