Results 171 to 180 of about 71,651 (313)

Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance

open access: yesImmunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT Thymic dendritic cells (DCs) are critical mediators of central tolerance, cooperating with medullary thymic epithelial cells (mTECs) and B cells to establish T‐cell self‐tolerance to the proteome. The DC compartment is highly heterogeneous and is comprised of three major subsets, plasmacytoid dendritic cells (pDCs) and two conventional ...
Aparna Calindi, Lauren I. R. Ehrlich
wiley   +1 more source

Targeting the Liver Serine Protease TMPRSS6 Ameliorates Steatosis and Attenuates Fibrosis in Experimental MASLD

open access: yesLiver International, Volume 45, Issue 7, July 2025.
ABSTRACT Background and Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common cause of liver disease and a leading contributor to liver‐related morbidity and mortality. Currently, no pharmacological approach has demonstrated consistent and long‐lasting benefits across all patients.
Mariateresa Pettinato   +18 more
wiley   +1 more source

Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology

open access: yesChemBioChem, Volume 26, Issue 11, June 3, 2025.
This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda   +2 more
wiley   +1 more source

A role for CD36 in the regulation of dendritic cell function [PDF]

open access: green, 2001
Britta C. Urban   +2 more
openalex   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, Volume 19, Issue 6, Page 1668-1686, June 2025.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

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