Results 11 to 20 of about 77,752 (295)

CD36 deficiency attenuates experimental mycobacterial infection [PDF]

BMC Infectious Diseases, 2010
Background Members of the CD36 scavenger receptor family have been implicated as sensors of microbial products that mediate phagocytosis and inflammation in response to a broad range of pathogens.
Min-Oo Gundula, Finney Constance, Diassiti Angelina, Crockett Maryanne, Li Xiaoming, Hawkes Michael, Liles W Conrad, Liu Jun, Kain Kevin C   +8 more
doaj   +4 more sources

CD36 Signaling in Diabetic Cardiomyopathy

Aging and disease, 2021
Cluster of differentiation 36 (CD36), also referred to as scavenger receptor B2, has been shown to serve multiple functions in lipid metabolism, inflammatory signaling, oxidative stress, and energy reprogramming. As a scavenger receptor, CD36 interacts with various ligands, such as oxidized low-density lipoprotein (oxLDL), thrombospondin 1 (TSP-1), and
Zhang, Xudong, Fan, Jiahui, Li, Huaping, Chen, Chen, Wang, Yan   +4 more
openaire   +2 more sources

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

CD36 Goes Native [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2008
There’s a saying that goes: “everything old is new again,” and I am reminded of this by the article by Luangrath et al1 in this issue of Arteriosclerosis, Thrombosis and Vascular Biology . Not that this article shows old data, but that what was old, now cast in a different light, leads to new ideas and hypotheses.
openaire   +2 more sources

Association between CD36 and ischemic stroke: consequential or coincidental? [PDF]

Exploration of Neuroscience
CD36 is a transmembrane protein that plays a role in various biological processes, including oxidized low-density lipoprotein and fatty acid uptake as well as regulatory control for inflammation signaling.
Ana-Maria Dobri-Nicoară, Ionela Daniela Popescu, Elena Codrici, Maria Dudău, Ana-Maria Enciu, Cristiana Tanase   +5 more
doaj   +1 more source

Metabolic and cardiac adaptation to chronic pharmacologic blockade of facilitative glucose transport in murine dilated cardiomyopathy and myocardial ischemia [PDF]

, 2018
GLUT transgenic and knockout mice have provided valuable insight into the role of facilitative glucose transporters (GLUTs) in cardiovascular and metabolic disease, but compensatory physiological changes can hinder interpretation of these models.
Heitmeier, Monique R., Hresko, Richard C., Hruz, Paul W., Jay, Patrick Y., Kovacs, Attila, Payne, Maria A., Weinheimer, Carla   +6 more
core   +2 more sources

Programming Skeletal Muscle Metabolic Flexibility in Offspring of Male Rats in Response to Maternal Consumption of Slow Digesting Carbohydrates during Pregnancy [PDF]

, 2020
Skeletal muscle plays a relevant role in metabolic flexibility and fuel usage and the associated muscle metabolic inflexibility due to high-fat diets contributing to obesity and type 2 diabetes.
Andújar, Eloísa, Bueno Vargas, Pilar, Girón, María D., Manzano, Manuel, Martín, María J., Pérez Alegre, Mónica, Salto, Rafael, Vílchez, Jose D.   +7 more
core   +1 more source

CD36: Implications in cardiovascular disease [PDF]

The International Journal of Biochemistry & Cell Biology, 2007
CD36 is a broadly expressed membrane glycoprotein that acts as a facilitator of fatty acid uptake, a signaling molecule, and a receptor for a wide range of ligands, including apoptotic cells, modified forms of low density lipoprotein, thrombospondins, fibrillar beta-amyloid, components of Gram positive bacterial walls and malaria infected erythrocytes.
Maria, Febbraio, Roy L, Silverstein
openaire   +2 more sources

Lymphocytes upregulate CD36 in adipose tissue and liver

Adipocyte, 2019
CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells ...
Jacob Couturier, Alli M. Nuotio-Antar, Neeti Agarwal, Gregory K. Wilkerson, Pradip Saha, Viraj Kulkarni, Samir K. Lakhashe, Juan Esquivel, Pramod N. Nehete, Ruth M. Ruprecht, K. Jagannadha Sastry, Jennifer M. Meyer, Lori R. Hill, Jordan E. Lake, Ashok Balasubramanyam, Dorothy E. Lewis   +15 more
doaj   +1 more source