Results 201 to 210 of about 53,340 (302)

PCSK9-Mediated Inflammation in Foam Cell Formation and Exploring the Biologically Active Compounds Derived From Natural Resources. [PDF]

Adv Pharmacol Pharm Sci
Wisesa MHM, Mathriul AQ, Suswidiantoro V, Puteri MU, Kato M, Idris MHM, Saputri FC.   +6 more
europepmc   +1 more source

Adipocyte‐Derived KIF13B Aggravates Obesity‐Associated Metabolic Dysfunction via LRP1/PPARγ Signaling

MedComm, Volume 7, Issue 10, October 2026.
Adipocyte‐derived KIF13B promotes LRP1 localization and nuclear LRP1–PPARγ transcriptional activity, thereby enhancing adipogenic gene expression, lipid accumulation, and obesity‐associated metabolic dysfunction. Adipocyte‐specific Kif13b deletion disrupts this LRP1/PPARγ axis, suppresses adipogenic programming, reduces adipose expansion, and protects ...
Guolin Miao, Zhaoling Li, Lianxin Zhang, Yitong Xu, Ziwei Wang, Zixun Wang, Aiden Xian, Liwen Zheng, Jingxuan Chen, Yufei Han, Chunhua Shan, Kaikai Lu, Ming Tao, Ling Zhang, Weiguang Zhang, Wei Huang, Yuhui Wang, Rui Wei, Erdan Dong, Xunde Xian   +19 more
wiley   +1 more source

Identification and Experimental Validation of Key Lipid Metabolism-Related Genes in Intracerebral Hemorrhage Based on Machine Learning. [PDF]

J Inflamm Res
Qiu W, Lin S, Chen L, Li S, Wang J.
europepmc   +1 more source

ITCH‐Mediated Ubiquitination and Degradation of THBS1: A Key Mechanism for Enhancing Mitochondrial Biogenesis and Alleviating Mouse Skeletal Muscle Atrophy

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear. Methods A muscle atrophy model was established
Wan Yu, Yanteng Wang, Na Li, Difei Wang
wiley   +1 more source

IL RUOLO DI CD36 NELL'ATEROSCLEROSI

Introduzione: Il CD36 è un recettore di membrana appartenente alla classe B dei recettori “scavenger” che lega le lipoproteine LDL ossidate, ed è espresso su molti tipi cellulari, tra cui i monociti.
SCOZZARO, MARIA TIZIANA
core  

The Involvement of the Small GTPase Rac1 in Insulin Signaling That Regulates Plasma Membrane Translocation of the Fatty Acid Transporter CD36 in Mouse White Adipocytes. [PDF]

Int J Mol Sci
Takenaka N, Sakata M, Abe Y, Iha K, Satoh T.   +4 more
europepmc   +1 more source

Transcriptomic and metabolomic analyses reveal that lobeglitazone ameliorates hepatic steatosis in rats concurrent with regulation of mitochondrial pyruvate metabolism

British Journal of Pharmacology, Volume 183, Issue 19, Page 5935-5952, October 2026.
Background and Purpose Lobeglitazone is a thiazolidinedione and PPARγ agonist that improves metabolic parameters and hepatic steatosis, but its mechanisms are not fully understood. This study investigated the effects of lobeglitazone on hepatic transcriptomic and metabolic profiles in a rat model of obesity and Type 2 diabetes mellitus.
Hyekyung Yang, Su Young Son, Youngmi Song, Hyewon Choi, In‐Gu Do, Choong Hwan Lee, Cheol‐Young Park   +6 more
wiley   +1 more source

TMEM135 deficiency prevents intestinal lipid accumulation by coordinating lipid uptake and oxidation through ELOVL6-mediated PPARα activation. [PDF]

Exp Mol Med
Kim H, Park C, Wei X, Chhetri A, Manandhar L, Seo J, Park Y, Lee SW, Park R.   +8 more
europepmc   +1 more source

Distinctive gene expression in the reduced first thoracic legs of a nymphalid butterfly

Insect Molecular Biology, Volume 35, Issue 5, Page 504-516, October 2026.
Transcriptome analysis reveals that the small non‐walking front legs of a butterfly have distinct gene expression to the four walking legs. Reduced front legs express a gene with putative mechanosensory roles, a blue‐sensitive opsin and two homeobox genes.
Asia E. Hoile, Peter O. Mulhair, Peter W. H. Holland   +2 more
wiley   +1 more source

Disulfiram Attenuates Adenine‐Induced Renal Fibrosis by Modulating Inflammatory and Immunometabolic Responses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Chronic kidney disease (CKD) is characterized by persistent inflammation that drives progressive renal injury and fibrosis. In this study, we demonstrate that disulfiram markedly attenuates kidney injury and fibrosis in adenine‐induced nephropathy by suppressing innate immune responses and reducing DNA damage and cellular senescence.
Saori Kin, Yuji Oe, Shun Ishigaki, Ichiro Fujio, Mariko Miyazaki, Tetsuhiro Tanaka   +5 more
wiley   +1 more source