Results 261 to 270 of about 83,609 (361)

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

MedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei   +10 more
wiley   +1 more source

Lipoprotein binding to the class B scavenger receptor CD36

, 2000
Willem J. de Villiers, Lei Cai, Marcielie C. de Beer, Nancy R. Webb, Frederick C. de Beer, Deneys R. van der Westhuyzen   +5 more
openalex   +1 more source

CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyloid Fibrils [PDF]

, 2002
Indra Sethy Coraci, Jens Husemann, Joan W. Berman, Christine Hulette, Jennifer Dufour, Gabriele K. Campanella, Andrew D. Luster, Samuel C. Silverstein, Joseph El Khoury   +8 more
openalex   +1 more source

CD36 as a marker of acute myeloid leukemia prognosis: A systematic review. [PDF]

Hematol Transfus Cell Ther
Amantéa MC, da Silva RP, Soares LR, Pereira JLM, de Souza APD.   +4 more
europepmc   +1 more source

Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics

MedComm, Volume 6, Issue 8, August 2025.
Macrophages originate from the yolk sac, fetal liver, and bone marrow, differentiating into two main subtypes: M1‐like (proinflammatory) and M2‐like (anti‐inflammatory). These subtypes exhibit high plasticity, allowing them to transform in response to environmental cues or therapeutic interventions.
Mengyuan Peng, Niannian Li, Hongbo Wang, Yaxu Li, Hui Liu, Yanhua Luo, Bao Lang, Weihang Zhang, Shilong Li, Liujun Tian, Bin Liu   +10 more
wiley   +1 more source

Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice [PDF]

, 2002
Tahar Hajri, Xiao Han, Arend Bonen, Nada A. Abumrad   +3 more
openalex   +1 more source

Human CD36: Gene Regulation, Protein Function, and Its Role in Atherosclerosis Pathogenesis. [PDF]

Genes (Basel)
Rac M.
europepmc   +1 more source

Lipid‐associated macrophages are more abundant in subcutaneous than visceral adipose tissue in patients with obesity

Obesity, Volume 33, Issue 8, Page 1543-1554, August 2025.
Abstract Objective Because white adipose tissue is infiltrated by several immune cells and their signature in individuals with obesity has not been fully characterized, we wanted to study the most abundant population, which is macrophages, a subtype of myeloid cell. Methods To address this objective, we performed transcriptomic analysis of subcutaneous
Marjorie Reyes‐Farias, Pablo Fernández‐García, Patricia Corrales, Lorena González, David Navarro‐Sanagustín, Andrea Soria‐Gondek, Silvia Pellitero, Jordi Tarascó, Pau Moreno, José M. Balibrea, Laia Gatell, Lauro Sumoy, María Galán, Ester Martínez, Francesc Villarroya, Rubén Cereijo, Laura Herrero, David Sánchez‐Infantes   +17 more
wiley   +1 more source

Changes in FAT/CD36, UCP2, UCP3 and GLUT4 gene expression during lipid infusion in rat skeletal and heart muscle [PDF]

, 2002
Roberto Vettor, Roberto Fabris, Roberto Serra, AM Lombardi, Cristina Tonello, Marnie Granzotto, MO Marzolo, Michele O. Carruba, Daniel Ricquier, Giovanni Federspil, Enzo Nisoli   +10 more
openalex   +1 more source

PLIN2 promotes colorectal cancer progression through CD36-mediated epithelial-mesenchymal transition. [PDF]

Cell Death Dis
Yang F, Li Y, Shang X, Zhu Y, Hou W, Liu Y, Hua Q, Sun Z.   +7 more
europepmc   +1 more source