Results 241 to 250 of about 53,340 (302)

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, Volume 3, Issue 3, September 2026.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Lipid metabolism in γδ T-cell activation: Implications for immunotherapy in ovarian cancer. [PDF]

Transl Oncol
Stirblyte K, Ghanem Y, Bates M, Gray SG, Saadeh FA, Martin C, O'Toole S, O'Leary JJ, Doherty DG, Mohamed BM.   +9 more
europepmc   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Research Advances in Nanodrugs Targeting Lipid Metabolism Reprogramming for Colorectal Cancer Therapy. [PDF]

Int J Nanomedicine
Tang J, Liu M, Zhang R, Li Q, Wang S, Wang Y.   +5 more
europepmc   +1 more source

Immune-Inflammatory Hub Genes Intersecting with a Ferroptosis-Associated Gene Set in Active Tuberculosis: A Multi-Dataset Bioinformatics Study. [PDF]

Int J Mol Sci
Elsayim R, Alqahtani MSM, Alaaullah MHI, Bin Suaydan RA, Abudouleh E, Mohamed SHA, Almuraikhi N.   +6 more
europepmc   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

PPARGC1A Modulation Attenuates Ferroptosis-Related Injury and Promotes Functional Recovery After Spinal Cord Injury: Potential Involvement of PPARγ Signaling. [PDF]

Eur J Neurosci
Wang D, Wu B, Liu C, Wu Y, Meng X, He X.
europepmc   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

Author Correction: Zearalenone causes female reproductive lipotoxicity through the ERα-CD36/TLR4 signaling pathway. [PDF]

Commun Biol
Dai C, Fu W, Huang Y, Li T, Ma Z, Chang X, Sun C, Wang S, Wu X, Li Y.   +9 more
europepmc   +1 more source

Advances in Lipid Metabolism Reprogramming in Hepatocellular Carcinoma. [PDF]

J Clin Transl Hepatol
Duan W, Jian Q, Sun B, Yang H, Deng Y, Peng Y, Liu S.   +6 more
europepmc   +1 more source