Results 21 to 30 of about 81,560 (343)
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate
Journal of Experimental Medicine, 2022 CD36 functions as both a signaling receptor and fatty acid transporter in various immune and non-immune cells. This review summarizes how its dual functions determine immune cell functions and fates, which contribute to common diseases including ...
Yiliang Chen +3 more
semanticscholar +1 more source
The Role of CD36 in Cancer Progression and Its Value as a Therapeutic Target
Cells, 2023 Cluster of differentiation 36 (CD36) is a cell surface scavenger receptor that plays critical roles in many different types of cancer, notably breast, brain, and ovarian cancers.
W. Feng, Hannah T. Zuppe, M. Kurokawa
semanticscholar +1 more source
CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease.
Physiological Reviews, 2023 The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and plays a key regulatory role in cellular lipid metabolism. CD36 facilitates the cellular uptake of long-chain fatty acids, mediates lipid signaling, and regulates ...
J. F. Glatz, L. Heather, J. Luiken
semanticscholar +1 more source
Nature Communications, 2023 Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of caveolin-1 tyrosine-14 (Cav-1Y14) and ceramide generation in caveolae ...
V. Peche +10 more
semanticscholar +1 more source
Plasma levels of CD36 and glutathione as biomarkers for ruptured intracranial aneurysm
Open Life Sciences, 2023 Evidence has proved that intracranial aneurysm (IA) formation and rupture might be closely related to inflammatory response and oxidative stress. Our objective was to evaluate the potential of CD36 and glutathione (GSH) as biomarkers for IA.
Wang Hanbin +7 more
doaj +1 more source
CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis
Nature Communications, 2022 Macrophage-mediated immune suppression contributes to poor outcome in liver metastasis. Here the authors show that CD36-expressing metastasis associated macrophages engulf tumor cell-derived extracellular vesicles enriched in long-chain fatty acids ...
Ping Yang +15 more
semanticscholar +1 more source
Cell Death and Disease, 2023 Obesity/overweight and lipid metabolism disorders have become increased risk factors for lung cancer. Fatty acid translocase CD36 promotes cellular uptake of fatty acids.
Li-Zhong Liu +10 more
semanticscholar +1 more source
Soluble CD36− a marker of the (pathophysiological) role of CD36 in the metabolic syndrome? [PDF]
Archives of Physiology and Biochemistry, 2011 CD36 is a class B scavenger receptor observed in many cell types and tissues throughout the body. Recent literature has implicated CD36 in the pathogenesis of metabolic dysregulation such as found in obesity, insulin resistance, and atherosclerosis.
Koonen, Debby P Y +2 more
openaire +4 more sources
Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
Cell Death and Disease, 2020 Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which can progress to cirrhosis and hepatocellular carcinoma ...
P. Rada +3 more
semanticscholar +1 more source
CD36 (SR-B2) as master regulator of cellular fatty acid homeostasis
Current Opinion in Lipidology, 2022 Purpose of review Transmembrane glycoprotein cluster of differentiation 36 (CD36) is a scavenger receptor class B protein (SR-B2) that serves various functions in lipid metabolism and signaling, in particular facilitating the cellular uptake of long ...
J. Glatz, M. Nabben, J. Luiken
semanticscholar +1 more source