Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia [PDF]
, 2014 Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although mechanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecules contributing to malignant expansion and ...
Bilban, Martin +15 more
core +1 more source
The role and mechanism of action of endoplasmic reticulum transmembrane protein 166 in liver lipid metabolism [PDF]
精准医学杂志Objective To investigate the role and specific molecular mechanism of action of endoplasmic reticulum transmembrane protein 166 (TMEM166) in liver lipid metabolism. Methods Tmem166flox/flox mice were crossed with Alb-Cre mice, and the offspring Tmem166+/+
LI Lianhui, YANG Di, ZANG Kailai, SUN Yani, DU Qiyuan, LI Ning
doaj +1 more source
Phenotypic and functional changes in blood monocytes following adherence to endothelium. [PDF]
PLoS ONE, 2012 ObjectiveBlood monocytes are known to express endothelial-like genes during co-culture with endothelium. In this study, the time-dependent change in the phenotype pattern of primary blood monocytes after adhering to endothelium is reported using a novel ...
Colin Tso, Kerry-Anne Rye, Philip Barter
doaj +1 more source
The microglial "activation" continuum: from innate to adaptive responses [PDF]
, 2005 Microglia are innate immune cells of myeloid origin that take up residence in the central nervous system (CNS) during embryogenesis. While classically regarded as macrophage-like cells, it is becoming increasingly clear that reactive microglia play more ...
Nikolic, Veljko +2 more
core +3 more sources
EBioMedicine, 2019 Background: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa.
Andriy Derkach +19 more
doaj +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2017 Objectives: To explore whether individuals infected with Plasmodium falciparum (P. falciparum) develop antibodies directed against PfEMP1-DBLα, and to assess their IgG subclass distribution in severe and uncomplicated malaria. Methods: The anti-PfDBLα
Natharinee Horata +4 more
doaj +1 more source
Cytoadhesion to gC1qR through Plasmodium falciparum Erythrocyte Membrane Protein 1 in Severe Malaria [PDF]
, 2016 Cytoadhesion of Plasmodium falciparum infected erythrocytes to gC1qR has been associated with severe malaria, but the parasite ligand involved is currently unknown.
Aide, Pedro Carlos Paulino +20 more
core +3 more sources
Oxidation by neutrophils-derived HOCl increases immunogenicity of proteins by converting them into ligands of several endocytic receptors involved in antigen uptake by dendritic cells and macrophages. [PDF]
PLoS ONE, 2015 The initiation of adaptive immune responses to protein antigens has to be preceded by their uptake by antigen presenting cells and intracellular proteolytic processing.
Rafał Biedroń +3 more
doaj +1 more source
Surface antigens in Plasmodium falciparum malaria : PfEMP1 and SURFIN4.2 [PDF]
, 2017 Plasmodium falciparum malaria is an infectious disease that on despite of the ongoing eradication efforts is still endemic in more than 100 countries, sometimes causing severe disease that leads to the death of around half a million people per year ...
Quintana Varon, Maria del Pilar
core +1 more source
Decrease of Very Late Activation Antigen-4 and CD36 on Reticulocytes in Sickle Cell Patients Treated With Hydroxyurea [PDF]
Blood, 1997 Abstract Sickle cell disease (SCD) is characterized by repeated vaso-occlusive events, which result in substantial morbidity. Abnormal adhesion of sickle red blood cells (RBC) to the vascular endothelium is postulated to play a role in the pathogenesis of vaso-occlusion.
L A, Styles +6 more
openaire +2 more sources