Results 61 to 70 of about 16,779 (207)

HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration

Advanced Science, EarlyView.
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong, Ziyun Liang, Tianqi Duo, Liping Pan, Qi Zhu, Jiete Liang, Xianyao Luo, Qingcai Feng, Rong Xu, Yihao Liu, Xu Chen, Luxi Chen, Xiaohong Liu, Yaosheng Chen, Delin Mo   +14 more
wiley   +1 more source

Influence of the Clinical Status on Stress Reticulocytes, CD 36 and CD 49d of SSFA2 Homozygous Sickle Cell Patients Followed in Abidjan

Advances in Hematology, 2014
Background and Objectives. Interactions between sickle cells involving CD 49d, CD36, and the vascular endothelium may initiate vasoocclusion leading to acute painful episodes and multiple organ failure. Materials and Methods.
Duni Sawadogo, Aïssata Tolo-Dilkébié, Mahawa Sangaré, Nelly Aguéhoundé, Hermance Kassi, Toussaint Latte   +5 more
doaj   +1 more source

Impact of intermittent preventive anti-malarial treatment on the growth and nutritional status of preschool children in rural Senegal (west Africa). [PDF]

, 2007
Negative consequences of malaria might account for seasonality in nutritional status in children in the Sahel. We report the impact of a randomized, double-blind, placebo-controlled trial of seasonal intermittent preventive anti-malarial treatment on ...
Alexander, Neal, Boulanger, Denis, Cissé, Badara, Greenwood, Brian M, Lines, Jo, Ntab, Balthazar, Simondon, François, Simondon, Kirsten B, Sokhna, Cheikh, Targett, Geoffrey, Trape, Jean-François   +10 more
core   +2 more sources

Differential regulation of CD36 expression in antigen-presenting cells: Oct-2 dependence in B lymphocytes but not dendritic cells or macrophages [PDF]

International Immunology, 2002
In mice, three antigen-presenting cell types [B lymphocytes, macrophages and dendritic cells (DC)] express the scavenger receptor CD36. This molecule has been implicated in many important functions, including DC maturation and antigen presentation. In murine B cells, the CD36 gene requires the Oct-2 transcription factor for its expression.
Lynn, Corcoran, David, Vremec, Maria, Febbraio, Tracey, Baldwin, Emanuela, Handman   +4 more
openaire   +2 more sources

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes [PDF]

, 2012
BACKGROUND: The ability of Plasmodium falciparum to undergo antigenic variation, by switching expression among protein variants encoded by multigene families, such as var, rif and stevor, is key to the survival of this parasite in the human host.
Bismarck Dinko, Christian W Wang, Colin J Sutherland, David E Arnot, Dominique C Bengtsson, John P Lusingu, Louise Turner, Mwakalinga, Steven B, Steven B Mwakalinga, Thomas Lavstsen, Thor G Theander   +10 more
core   +2 more sources

Cholesterol Metabolism Regulated Nanoliposome Ameliorates Chemo/Photothermal Therapy Reversing CD8+ T Cell Exhaustion

Exploration, EarlyView.
Our work addresses the challenge of treating triple‐negative breast cancer by developing a multifunctional nanoliposome, ictLipo. The goal was to enhance antitumor immunity by combining photothermal therapy and chemotherapy while simultaneously tackling two major roadblocks: immunosuppression from cholesterol in the tumor microenvironment and therapy ...
Panpan Xue, Tingjie Bai, Huilan Zhuang, Angelo H. All, Shuangqian Yan, Xuemei Zeng   +5 more
wiley   +1 more source

Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali.

PLoS ONE, 2013
Malaria still remains a major public health problem in Mali, although disease susceptibility varies between ethnic groups, particularly between the Fulani and Dogon. These two sympatric groups share similar socio-cultural factors and malaria transmission
Bakary Maiga, Amagana Dolo, Ousmane Touré, Victor Dara, Amadou Tapily, Susana Campino, Nuno Sepulveda, Paul Risley, Nilupa Silva, Patrick Corran, Kirk A Rockett, Dominic Kwiatkowski, MalariaGEN Consortium, Taane G Clark, Marita Troye-Blomberg, Ogobara K Doumbo   +15 more
doaj   +1 more source