Results 71 to 80 of about 1,186,345 (240)

CD36 or αvβ3 and αvβ5 Integrins Are Not Essential for MHC Class I Cross-Presentation of Cell-Associated Antigen by CD8α+ Murine Dendritic Cells [PDF]

The Journal of Immunology, 2002
AbstractCross-presentation of cell-associated Ag is thought to involve receptor-mediated uptake of apoptotic cells by dendritic cells (DC), and studies with human DC strongly implicate the endocytic receptor CD36 and the integrins αvβ3 and/or αvβ5 in this process. In the mouse, cross-presentation was recently shown to be a function of CD8α+ DC. Here we
Oliver Schulz, Daniel J. Pennington, Kairbaan Hodivala-Dilke, Maria Febbraio, Caetano Reis e Sousa   +4 more
openaire   +1 more source

Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae.

, 2001
Combination therapy that includes artemisinin derivatives cures most falciparum malaria infections. Lowering transmission by reducing gametocyte infectivity would be an additional benefit.
Targett, G, Drakeley, C, Jawara, M, von Seidlein, L, Coleman, R, Deen, J, Pinder, M, Doherty, T, Sutherland, C, Walraven, G, Milligan, P   +10 more
core   +1 more source

Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response to Plasmodium falciparum VAR2CSA-Expressing Parasites [PDF]

, 2011
Pregnancy-associated malaria, a manifestation of severe malaria, is the cause of up to 200,000 infant deaths a year, through the effects of placental insufficiency leading to growth restriction and preterm delivery.
Andrew W. Taylor-Robinson, Elizabeth G. Kane   +1 more
core   +2 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali.

PLoS ONE, 2013
Malaria still remains a major public health problem in Mali, although disease susceptibility varies between ethnic groups, particularly between the Fulani and Dogon. These two sympatric groups share similar socio-cultural factors and malaria transmission
Bakary Maiga, Amagana Dolo, Ousmane Touré, Victor Dara, Amadou Tapily, Susana Campino, Nuno Sepulveda, Paul Risley, Nilupa Silva, Patrick Corran, Kirk A Rockett, Dominic Kwiatkowski, MalariaGEN Consortium, Taane G Clark, Marita Troye-Blomberg, Ogobara K Doumbo   +15 more
doaj   +1 more source

Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach

BMC Genomics, 2010
Background Despite rhabdoviral infections being one of the best known fish diseases, the gene expression changes induced at the surface tissues after the natural route of infection (infection-by-immersion) have not been described yet. This work describes
Figueras Antonio, Estepa Amparo, Novoa Beatriz, Rodriguez-Milla Miguel A, Encinas Paloma, Coll Julio   +5 more
doaj   +1 more source

Capacity strengthening in malaria research: the Gates Malaria Partnership.

, 2006
The Gates Malaria Partnership (GMP) includes five African and four European partner institutions. Its research programme has five priority areas involving an extensive range of field-based studies.
Bhasin, Amit, Bowler, Cathy H, Greenwood, Brian M, Naylor, Heather, Targett, Geoffrey A   +4 more
core   +1 more source

Infectivity of Plasmodium falciparum in malaria-naive individuals is related to knob expression and cytoadherence of the parasite [PDF]

, 2016
Plasmodium falciparum is the most virulent human malaria parasite because of its ability to cytoadhere in the microvasculature. Nonhuman primate studies demonstrated relationships among knob expression, cytoadherence, and infectivity.
Beeson, James G., Chan, Jo-Anne A., Fink, James, Gerrard, John, Good, Michael F., Griffin, Paul M., Hackett, Hazel, Hanssen, Eric, Hoffman, Stephen L., Langer, Christine, Liu, Xue Q., McCarthy, James S., Pingnet, Jolien, Rodriguez, Ingrid B., Sekuloski, Silvana, Stanisic, Danielle I., Sundac, Lana, Trenholme, Katharine R., Wang, Claire Y. T., Yang, Yuedong, Zhou, Yaoqi   +20 more
core   +1 more source

The Application Value of Flow Cytometry‐Based Peripheral Blood Leukocyte Classification in Screening for Acute Leukemia and Posttreatment Monitoring

Journal of Clinical Laboratory Analysis, EarlyView.
Example of leukocyte classification results by FCM. The 16 cell populations are displayed in different colors according to the set gate logic. ABSTRACT Objective Assess the application value of flow cytometry (FCM) for peripheral blood leukocyte (PBL) classification in acute leukemia (AL) screening and monitoring.
Penghua Yan, Lianfeng Wu, Xiangyang Lin, Hong Lu, Jingjing Qian   +4 more
wiley   +1 more source