Results 91 to 100 of about 16,744 (229)
Inflammation, Immunity, and Cardiovascular Diseases
Med Research, EarlyView.Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo +8 more
wiley +1 more source
Advanced ScienceThe colon is the largest compartment of the immune system, with innate immune cells exposed to antigens in the environment. However, the mechanisms by which the innate immune system is instigated are poorly defined in colorectal cancer (CRC).
Yan Zhang +11 more
doaj +1 more source
Developmental allometry and paediatric malaria [PDF]
, 2012 WHO estimates that 80% of mortality due to malaria occurs among infants and young children. Though it has long been established that malaria disproportionately affects children under age five, our understanding of the underlying biological mechanisms for
Eleanor M Riley +3 more
core +3 more sources
The Journal of Pathology, EarlyView.Abstract Dystrophinopathies are caused by pathogenic variants in the DMD gene, resulting in partial (Becker) or complete loss (Duchenne) of dystrophin. Becker (BMD) and Duchenne muscular dystrophy (DMD) are characterized by progressive muscle wasting, fatty replacement, fibrosis, and loss of function.
Laura GM Heezen +14 more
wiley +1 more source
Small Methods, EarlyView.This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto +12 more
wiley +1 more source
Genetic polymorphisms linked to susceptibility to malaria [PDF]
, 2011 The influence of host genetics on susceptibility to Plasmodium falciparum malaria has been extensively studied over the past twenty years. It is now clear that malaria parasites have imposed strong selective forces on the human genome in endemic regions.
Adel Driss +5 more
core +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó +9 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary ETV6‐related thrombocytopenia (ETV6‐RT) is an inherited platelet disorder caused by germline ETV6 variants. Despite recent progress, the mechanisms underlying platelet dysfunction in ETV6‐RT remain unclear. We investigated 12 patients from six families using functional assays, electron microscopy, quantitative proteomics and cytoskeletal ...
Ivan P. Tesakov +15 more
wiley +1 more source
Surface antigens in Plasmodium falciparum malaria : PfEMP1 and SURFIN4.2 [PDF]
, 2017 Plasmodium falciparum malaria is an infectious disease that on despite of the ongoing eradication efforts is still endemic in more than 100 countries, sometimes causing severe disease that leads to the death of around half a million people per year ...
Quintana Varon, Maria del Pilar
core +1 more source
Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging
Cancer Science, EarlyView.Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka +4 more
wiley +1 more source