Results 11 to 20 of about 67,119 (304)
CD38 in Neurodegeneration and Neuroinflammation [PDF]
Cells, 2020 Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as microglial cells, the role played by CD38 in neurodegeneration ...
Serge Guerreiro, Damien Toulorge
exaly +6 more sources
Roles of CD38 in the Immune Response to Infection [PDF]
Cells, 2020 CD38 is a multifunctional protein widely expressed in cells from the immune system and as a soluble form in biological fluids. CD38 expression is up-regulated by an array of inflammatory mediators, and it is frequently used as a cell activation marker ...
Estibaliz Glaría +2 more
exaly +6 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on CD38 (CD38 molecule), with data on DNA, on the protein encoded, and where the gene is implicated.
Deaglio, S, Vaisitti, T
openaire +3 more sources
CD38 in Advanced Prostate Cancers [PDF]
European Urology, 2021 Background CD38, a druggable ectoenzyme, is involved in the generation of adenosine, which is implicated in tumour immune evasion. Its expression and role in prostate tumour-infiltrating immune cells (TIICs) have not been elucidated. Objective To characterise CD38 expression on prostate cancer (PC) epithelial cells and TIICs, and to associate this
Christina Guo +93 more
core +13 more sources
CD38: A NAADP degrading enzyme [PDF]
FEBS Letters, 2011 The role of the multifunctional enzyme CD38 in formation of the Ca(2+)-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice.
Schmid, Frederike +4 more
openaire +3 more sources
Controversy in the Use of CD38 Antibody for Treatment of Myeloma: Is High CD38 Expression Good or Bad? [PDF]
Cells, 2020 During a time span of just a few years, the CD38 antibody, daratumumab, has been established as one of the most important new drugs for the treatment of multiple myeloma, both in the relapsed/refractory setting and, more recently, as a first-line ...
Torben Plesner +2 more
doaj +3 more sources
EBioMedicine, 2023 Summary: Background: HexaBody®-CD38 (GEN3014) is a hexamerization-enhanced human IgG1 that binds CD38 with high affinity. The E430G mutation in its Fc domain facilitates the natural process of antibody hexamer formation upon binding to the cell surface,
Ida H. Hiemstra +19 more
doaj +2 more sources
Assessment of miR-150-5 p as diagnostic and prognostic markers of B- chronic Lymphocytic Leukemia in chronic hepatitis C [PDF]
African Journal of Gastroenterology and Hepatology, 2023 Aims: the current study aimed to investigate the role of miR-150-5 p expression as a diagnostic and prognostic marker of B- CLL among Egyptian patients with chronic hepatitis C and its impact on risk stratification and response to therapy.Patients ...
Nearmeen Rashad +6 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2022 Introduction: Solitary plasmacytoma (SP) is a rare plasma cell disorder characterized by localized neoplastic proliferation of monoclonal plasma cell. Due to its rarity, further understanding of the spectrum of its clinicopathologic features is needed ...
Yueying Li +5 more
doaj +1 more source
Evaluation of Relationship between CD38 Expression and Gleason Score in Prostatic Carcinoma [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: Prostate cancer is the most prevalent non-cutaneous malignancy in men. The Gleason grading system is an important prognostic factor in prostatic carcinoma.
Mohsen Besharati Rad +1 more
doaj