Results 11 to 20 of about 71,533 (257)

CD38 in Advanced Prostate Cancers [PDF]

, 2021
Background: CD38, a druggable ectoenzyme, is involved in the generation of adenosine, which is implicated in tumour immune evasion. Its expression and role in prostate tumour-infiltrating immune cells (TIICs) have not been elucidated.
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core   +9 more sources

The high-performance technology CRISPR/Cas9 improves knowledge and management of acute myeloid leukemia

Biomedical Papers, 2021
Knowledge on acute myeloid leukemia pathogenesis and treatment has progressed recently, but not enough to provide ideal management. Improving the prognosis of acute myeloid leukemia patients depends on advances in molecular biology for the detection of ...
Romeo Gabriel Mihaila, Diana Topircean
doaj   +1 more source

Anti CD38 monoclonal antibodies for multiple myeloma treatment

Human Vaccines & Immunotherapeutics, 2022
CD38 is a transmembrane glycoprotein with ectoenzymatic activity and is highly and uniformly expressed on multiple myeloma (MM) cells. CD38 is expressed also at relatively low levels on normal lymphoid and myeloid cells, and in some tissues of non ...
Alessandro Gozzetti, Sara Ciofini, Martina Simoncelli, Adele Santoni, Paola Pacelli, Donatella Raspadori, Monica Bocchia   +6 more
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Plasmablastic Lymphoma with Primary Impairment of Bone Marrow in a HIV-Negative Patient: A Literature Review and a Case Report

Клиническая онкогематология, 2022
Background. Plasmablastic lymphoma (PBL) is a rare variant of large B-cell lymphoma. This disease is usually associated with HIV infection and is predominantly identified in male patients. Tumor lesion is typically localized in oral cavity.
Maiya Valerevna Firsova, M. V. Solov’ev, A. M. Kovrigina, L. P. Mendeleeva   +3 more
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CD38-Directed Vincristine Nanotherapy for Acute Lymphoblastic Leukemia

, 2021
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Although intensive chemotherapy greatly improved the survival rate, it is often accompanied by severe and lifelong side effects as a result of weak ALL selectivity.
Jinping Zhang (461246), Yu Shao (40589), Yifan Zhang (119570), Jingnan An (10580971), Jingnan An, Na Yu (151735), Wenxing Gu, Shujing Yue (7444919), Yifan Zhang, Jubin Zhang, Yifeng Xia, Huanli Sun (1483117), Jubin Zhang (11845720), Yang Xu, Yang Xu (178421), Huanli Sun, Zhiyuan Zhong (1403683), Jinping Zhang, Zhiyuan Zhong, Yu Shao, Shujing Yue, Yifeng Xia (204099), Na Yu, Wenxing Gu (4336930)   +23 more
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Rising of intracellular NAD+ level and oppositely directed changes in CD38 expression in hippocampal cells in experimental Alzheimer’s disease

Сибирский научный медицинский журнал, 2021
The aim of the study was to assess the level of NAD+ in the brain of mice treated with beta-amyloid (Aβ), as well as to determine the activity of ADP-ribosyl cyclase/CD38 and the number of CD38-immunopositive neurons, astrocytes and endothelial cells ...
A. A. Semenova, Ya. V. Gorina, E. D. Khilazheva, E. V. Kharitonova, A. B. Salmina   +4 more
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Daratumumab

Indian Journal of Medical and Paediatric Oncology, 2020
Multiple myeloma is a proliferative disorder of plasma cells in the bone marrow with excessive monoclonal protein production. Despite the evolution of multiple drugs and management strategies including maintenance and autologous stem cell transplantation,
Vishnu Gopal, Biswajit Dubashi
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CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Cells, 2019
Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-
Haruhiro Higashida, Minako Hashii, Yukie Tanaka, Shigeru Matsukawa, Yoshihiro Higuchi, Ryosuke Gabata, Makoto Tsubomoto, Noriko Seishima, Mitsuyo Teramachi, Taiki Kamijima, Tsuyoshi Hattori, Osamu Hori, Chiharu Tsuji, Stanislav M. Cherepanov, Anna A. Shabalova, Maria Gerasimenko, Kana Minami, Shigeru Yokoyama, Sei-ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Alla B. Salmina, Olga Lopatina   +22 more
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Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro

Biology Open, 2021
The organic anion transporter Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1), also known as MRP1, has been demonstrated in murine models of Alzheimer's disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the ...
Wayne M. Jepsen, Matthew De Both, Ashley L. Siniard, Keri Ramsey, Ignazio S. Piras, Marcus Naymik, Adrienne Henderson, Matthew J. Huentelman   +7 more
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Expanding anti-CD38 immunotherapy for lymphoid malignancies [PDF]

, 2022
BACKGROUND: Lymphoid neoplasms, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and NK/T cell neoplasms, are a major cause of blood cancer morbidity and mortality.
Wang, Xu, Liu, Ming, Li, Ling, Young, Ken H., Li, Wei, Li, Yong, Fang, Xiaosheng, Yu, Xinfang, Young, Ken H, Zhang, Mingzhi, Neeli, Praveen   +10 more
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