Results 21 to 30 of about 67,119 (304)

Harnessing the Power of CAR-NK Cells: A Promising Off-the-Shelf Therapeutic Strategy for CD38-Positive Malignancies [PDF]

Iranian Journal of Immunology, 2023
Background: CD38 is highly expressed on multiple myeloma (MM) cells and has been successfully targeted by different target therapy methods. This molecule is a critical prognostic marker in both diffuse large B-cell lymphoma and chronic lymphocytic ...
Maryam Asadi, Razie Kiani, Vahid Razban, Seyed Faraji, Amirhossein Ahmadi, Jafar Fallahi, Amin Ramezani, Nasrollah Erfani   +7 more
doaj   +1 more source

The role of CD38 in HIV infection [PDF]

AIDS Research and Therapy, 2021
AbstractThe widely-expressed molecule CD38 is a single-stranded type II transmembrane glycoprotein that is mainly involved in regulating the differentiation and activation state of the cell. CD38 has broad and complex functions, including enzymatic activity, intercellular signal transduction, cell activation, cytokine production, receptor function and ...
Liqi Lu, Jie Wang, Qian Yang, Xiuqiao Xie, Yuanshuai Huang   +4 more
openaire   +3 more sources

Immune Phenotype and Functionality of Mtb-Specific T-Cells in HIV/TB Co-Infected Patients on Antiretroviral Treatment

Pathogens, 2020
The performance of host blood-based biomarkers for tuberculosis (TB) in HIV-infected patients on antiretroviral therapy (ART) has not been fully assessed.
Lucy Mupfumi, Cheleka A.M. Mpande, Tim Reid, Sikhulile Moyo, Sanghyuk S. Shin, Nicola Zetola, Tuelo Mogashoa, Rosemary M. Musonda, Ishmael Kasvosve, Thomas J. Scriba, Elisa Nemes, Simani Gaseitsiwe   +11 more
doaj   +1 more source

Jujuboside a improved energy metabolism in senescent H9c2 cells injured by ischemia, hypoxia, and reperfusion through the CD38/Silent mating type information regulation 2 homolog 3 signaling pathway

World Journal of Traditional Chinese Medicine, 2023
Objective: This study explored the myocardial protection role of Jujuboside A through an ischemia–hypoxia–reperfusion (IHR) model. Materials and Methods: H9c2 cells were induced by D-galactose (D-gal) and IHR to establish an aging and IHR model.
Yi-Ran Hu, Hui-Yan Qu, Jia-Ying Guo, Tao Yang, Hua Zhou   +4 more
doaj   +1 more source

Targeting CD38-Expressing Multiple Myeloma and Burkitt Lymphoma Cells In Vitro with Nanobody-Based Chimeric Antigen Receptors (Nb-CARs)

Cells, 2020
The NAD-hydrolyzing ecto-enzyme CD38 is overexpressed by multiple myeloma and other hematological malignancies. We recently generated CD38-specific nanobodies, single immunoglobulin variable domains derived from heavy-chain antibodies naturally occurring
Julia Hambach, Kristoffer Riecken, Sophia Cichutek, Kerstin Schütze, Birte Albrecht, Katharina Petry, Jana Larissa Röckendorf, Natalie Baum, Nicolaus Kröger, Timon Hansen, Gunter Schuch, Friedrich Haag, Gerhard Adam, Boris Fehse, Peter Bannas, Friedrich Koch-Nolte   +15 more
doaj   +1 more source

Expression of microRNA-155 in circulating T cells is an indicator of immune activation levels in HIV-1 infected patients

HIV Research & Clinical Practice, 2021
Objectives: MicroRNA-155 (miR-155) regulates activation of T cells. However, its relationship with T-cell immune activation level in human immunodeficiency virus (HIV) patients remains unclear.
Zhenghao Zhang, Yong Wu, Jiangnan Chen, Fangqing Hu, Xuefang Chen, Wenfang Xu   +5 more
doaj   +1 more source

The high-performance technology CRISPR/Cas9 improves knowledge and management of acute myeloid leukemia

Biomedical Papers, 2021
Knowledge on acute myeloid leukemia pathogenesis and treatment has progressed recently, but not enough to provide ideal management. Improving the prognosis of acute myeloid leukemia patients depends on advances in molecular biology for the detection of ...
Romeo Gabriel Mihaila, Diana Topircean
doaj   +1 more source

CD38-Directed Vincristine Nanotherapy for Acute Lymphoblastic Leukemia

, 2021
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Although intensive chemotherapy greatly improved the survival rate, it is often accompanied by severe and lifelong side effects as a result of weak ALL selectivity.
Jinping Zhang (461246), Yu Shao (40589), Yifan Zhang (119570), Jingnan An (10580971), Jingnan An, Na Yu (151735), Wenxing Gu, Shujing Yue (7444919), Yifan Zhang, Jubin Zhang, Yifeng Xia, Huanli Sun (1483117), Jubin Zhang (11845720), Yang Xu, Yang Xu (178421), Huanli Sun, Zhiyuan Zhong (1403683), Jinping Zhang, Zhiyuan Zhong, Yu Shao, Shujing Yue, Yifeng Xia (204099), Na Yu, Wenxing Gu (4336930)   +23 more
core   +1 more source

Anti CD38 monoclonal antibodies for multiple myeloma treatment

Human Vaccines & Immunotherapeutics, 2022
CD38 is a transmembrane glycoprotein with ectoenzymatic activity and is highly and uniformly expressed on multiple myeloma (MM) cells. CD38 is expressed also at relatively low levels on normal lymphoid and myeloid cells, and in some tissues of non ...
Alessandro Gozzetti, Sara Ciofini, Martina Simoncelli, Adele Santoni, Paola Pacelli, Donatella Raspadori, Monica Bocchia   +6 more
doaj   +1 more source

Plasmablastic Lymphoma with Primary Impairment of Bone Marrow in a HIV-Negative Patient: A Literature Review and a Case Report

Клиническая онкогематология, 2022
Background. Plasmablastic lymphoma (PBL) is a rare variant of large B-cell lymphoma. This disease is usually associated with HIV infection and is predominantly identified in male patients. Tumor lesion is typically localized in oral cavity.
Maiya Valerevna Firsova, M. V. Solov’ev, A. M. Kovrigina, L. P. Mendeleeva   +3 more
doaj   +1 more source