Results 31 to 40 of about 67,119 (304)

Rising of intracellular NAD+ level and oppositely directed changes in CD38 expression in hippocampal cells in experimental Alzheimer’s disease

Сибирский научный медицинский журнал, 2021
The aim of the study was to assess the level of NAD+ in the brain of mice treated with beta-amyloid (Aβ), as well as to determine the activity of ADP-ribosyl cyclase/CD38 and the number of CD38-immunopositive neurons, astrocytes and endothelial cells ...
A. A. Semenova, Ya. V. Gorina, E. D. Khilazheva, E. V. Kharitonova, A. B. Salmina   +4 more
doaj   +1 more source

Daratumumab

Indian Journal of Medical and Paediatric Oncology, 2020
Multiple myeloma is a proliferative disorder of plasma cells in the bone marrow with excessive monoclonal protein production. Despite the evolution of multiple drugs and management strategies including maintenance and autologous stem cell transplantation,
Vishnu Gopal, Biswajit Dubashi
doaj   +1 more source

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Cells, 2019
Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-
Haruhiro Higashida, Minako Hashii, Yukie Tanaka, Shigeru Matsukawa, Yoshihiro Higuchi, Ryosuke Gabata, Makoto Tsubomoto, Noriko Seishima, Mitsuyo Teramachi, Taiki Kamijima, Tsuyoshi Hattori, Osamu Hori, Chiharu Tsuji, Stanislav M. Cherepanov, Anna A. Shabalova, Maria Gerasimenko, Kana Minami, Shigeru Yokoyama, Sei-ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Alla B. Salmina, Olga Lopatina   +22 more
doaj   +1 more source

Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro

Biology Open, 2021
The organic anion transporter Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1), also known as MRP1, has been demonstrated in murine models of Alzheimer's disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the ...
Wayne M. Jepsen, Matthew De Both, Ashley L. Siniard, Keri Ramsey, Ignazio S. Piras, Marcus Naymik, Adrienne Henderson, Matthew J. Huentelman   +7 more
doaj   +1 more source

Double CD38–/CD138– negative multiple myeloma

Hematology/Oncology and Stem Cell Therapy, 2017
The standard diagnosis of multiple myeloma by flow cytometry is based on selection of population of CD38+/CD138+ positives cells. As the result treatment with proteasome inhibitors, CD138 may be underexpressed on atypical plasma cells.
Vitaliy Mykytiv, Abrar Alwaheed, Nurul Asyikin Mohd Hashim   +2 more
doaj   +1 more source

IMMUNOHISTOCHEMICAL STUDY OF PROTEINS PROX1, CD133 AND CD38 IN GLIOBLASTOMAS OF THE VENTRICULARSUBVENTRICULAR ZONE AND THEIR EFFECT ON THE LIFE EXPECTANCY OF PATIENTS

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2020
Introduction. Glioblastoma (GBM) is one of the most malignant tumors. Currently, treatment options for GBM are limited, and patient survival rates over the past decades have not changed significantly.The objective of the study was a comparative study of ...
B. E. Galkovsky, L. B. Mitrofanova, Iu. S. Lakhina, D. A. Gulyaev, V. Y. Chirkin, N. A. Mitrofanov, I. V. Chistova   +6 more
doaj   +1 more source

Design, synthesis and biological characterization of novel inhibitors of CD38 [PDF]

, 2011
Human CD38 is a novel multi-functional protein that acts not only as an antigen for B-lymphocyte activation, but also as an enzyme catalyzing the synthesis of a Ca 2+ messenger molecule, cyclic ADP-ribose, from NAD +.
Sun, Shuang-Yong, Hao, Q, Yuan-Qi Si, Liang-Ren Zhang, Fung Ping Leung, Zhang, LH, Zhou, Y, Li-He Zhang, Jianbo Yue, Min Dong, Yang, Zhen-Jun, Pu, XP, Si, Yuan-Qi, Quan Hao, Zhang, Liang-Ren, Pu, Xiao-Ping, Lam, Connie Mo Ching., Leung, FP, Kriksunov, IA, Dong, Min, Anna Ka Yee Kwong, Sun, SY, Lee, Hon Cheung, Xiao-Ping Pu, Zhen-Jun Yang, Zhou, Yeyun, Kwong, Anna Ka Yee, Irina A. Kriksunov, Cheung Lee, H, Hon Cheung Lee, Yue, J, Zhang, Li-He, Hao, Quan, Leung, Fung Ping, Kriksunov, Irina A., Dong, M, Shuang-Yong Sun, Connie Mo Ching. Lam, Si, YQ, Zhang, LR, Lam, CMC, Kwong, AKY, Yang, ZJ, Yue, Jianbo, Yeyun Zhou   +44 more
core   +1 more source

Targeting CD38 for acute leukemia

Frontiers in Oncology, 2022
Acute leukemia (AL) is a hematological malignancy, and the prognosis of most AL patients hasn’t improved significantly, particularly for relapsed or refractory (R/R) AL. Therefore, new treatments for R/R adult acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are urgently necessary.
Xushu Zhong, Hongbing Ma
openaire   +3 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Immune signature profiling identified predictive and prognostic factors for esophageal squamous cell carcinoma

OncoImmunology, 2017
Understanding interactions between tumor and the host immune system holds great promise to uncover biomarkers for targeted therapies and clinical outcomes.
Yuan Li, Zhiliang Lu, Yun Che, Jingnan Wang, Shouguo Sun, Jianbing Huang, Shuangshuang Mao, Yuanyuan Lei, Zhaoli Chen, Jie He   +9 more
doaj   +1 more source