Results 31 to 40 of about 71,533 (257)

The effect of sodium deoxyribonucleate with iron complex on the expression of surface markers of MT-4 cells infected with human immunodeficiency virus type 1 (HIV-1) (Retroviridae: Primate lentivirus group)

Вопросы вирусологии
Introduction. The persistence of immune dysfunction during therapy has serious consequences for the health of HIV-infected people. Therefore, an important direction is the search for drugs that can reduce the inflammatory potential of the immune system ...
Dmitry N. Nosik, Lyudmila B. Kalnina, Lyudmila M. Selimova, Ellie N. Kaplina   +3 more
doaj   +1 more source

Clinical Staging and Flowcytometric CD38 and Zap-70 Prognostic Indicators in Sudanese Patients with Chronic Lymphocytic Leukemia

Sudan Journal of Medical Sciences, 2020
Background: The clinical course of chronic lymphocytic leukemia is highly variable. The determination of ZAP70 and CD38 is increasingly utilized as prognostic factor for chronic lymphocytic leukemia.
Enaam Abdelrhman Abdelgader, Nada Hassan Eltayeb, Tasniem Ahmed Eltahir, Osama Ali Altayeb, Eman Abbass Fadul, Soaad Fadlallah Ali, Eldirdiri M. Abdelrhman   +6 more
doaj   +1 more source

Enhanced tumor regression and synergistic activity of anti-CD38-IFNα(att) compared to standard MM therapeutics.

, 2016
(A) Tumor volumes from NCI-H929 tumor bearing SCID mice treated with 5mg/kg anti-CD38-IFNα(att), twice a week for 3 weeks or standard MM therapeutic agents including dexamethasone (10 mg/kg, daily for 28 days), lenalidomide (25 mg/kg, daily for 21 days),
James Berenson (3111285), Anthony Doyle (577129), Yong Yun (3111264), Haiming Chen (355433), David S. Wilson (36463), Maya Sokolovsky (3111255), Moti Rosenstock (3111276), Eric Sanchez (3111288), Tetsuya Taura (3111270), Steffen Nock (3111279), Collette Behrens (3111261), Angela Sho (3111273), Sarah L. Pogue (3111267), Hussein Hallak (3019602), Mingying Bi (3111258), Glen Mikesell (3111282)   +15 more
core   +1 more source

THE FEATURES OF CONNEXINS EXPRESSION IN THE CELLS OF NEUROVASCLAR UNIT IN NORMAL CONDITIONS AND HYPOXIA IN VITRO

Бюллетень сибирской медицины, 2014
The aim of this research was to assess a role of connexin 43 (Cx43) and associated molecule CD38 in the regulation of cell-cell interactions in the neurovascular unit (NVU) in vitro in physiological conditions and in hypoxia.Materials and methods.
A. V. Morgun, N. V. Kuvacheva, Ye. D. Khilazheva, T. Ye. Taranushenko, A. B. Salmina   +4 more
doaj   +1 more source

Controversy in the Use of CD38 Antibody for Treatment of Myeloma: Is High CD38 Expression Good or Bad?

Cells, 2020
During a time span of just a few years, the CD38 antibody, daratumumab, has been established as one of the most important new drugs for the treatment of multiple myeloma, both in the relapsed/refractory setting and, more recently, as a first-line ...
Torben Plesner, Niels W. C. J. van de Donk, Paul G. Richardson   +2 more
doaj   +1 more source

Antigen specificity index (ASI) of anti-CD38-IFNα and attenuated variants.

, 2016
Antigen specificity index (ASI) of anti-CD38-IFNα and attenuated variants.
James Berenson (3111285), Anthony Doyle (577129), Yong Yun (3111264), Haiming Chen (355433), David S. Wilson (36463), Maya Sokolovsky (3111255), Moti Rosenstock (3111276), Eric Sanchez (3111288), Tetsuya Taura (3111270), Steffen Nock (3111279), Collette Behrens (3111261), Angela Sho (3111273), Sarah L. Pogue (3111267), Hussein Hallak (3019602), Mingying Bi (3111258), Glen Mikesell (3111282)   +15 more
core   +1 more source

Anti-CD38-IFNα(att) retains strong on-target tumor cell activity with reduced off-target activity in vitro.

, 2016
Two assays were used to evaluate the antigen specificity of anti-CD38 targeted IFNα’s. The graphs on the left show viability assays of treated ARP-1 MM cells three days after incubation with IFNα compounds.
James Berenson (3111285), Anthony Doyle (577129), Yong Yun (3111264), Haiming Chen (355433), David S. Wilson (36463), Maya Sokolovsky (3111255), Moti Rosenstock (3111276), Eric Sanchez (3111288), Tetsuya Taura (3111270), Steffen Nock (3111279), Collette Behrens (3111261), Angela Sho (3111273), Sarah L. Pogue (3111267), Hussein Hallak (3019602), Mingying Bi (3111258), Glen Mikesell (3111282)   +15 more
core   +1 more source

Daratumumab induces CD38 internalization and impairs myeloma cell adhesion

OncoImmunology, 2018
Daratumumab (Dara), a human immunoglobulin G1 kappa (IgG1κ) monoclonal anti-CD38 antibody, has been approved by the U.S. Food and Drug Administration for the treatment of relapsed multiple myeloma (MM) as a single agent as well as in combination with ...
Jayeeta Ghose, Domenico Viola, Cesar Terrazas, Enrico Caserta, Estelle Troadec, Jihane Khalife, Emine Gulsen Gunes, James Sanchez, Tinisha McDonald, Guido Marcucci, Balveen Kaur, Michael Rosenzweig, Jonathan Keats, Steven Rosen, Amrita Krishnan, Abhay R Satoskar, Craig C Hofmeister, Flavia Pichiorri   +17 more
doaj   +1 more source

Anti-CD38-IFNα(att) induces profound anti-tumor activity on large, well-established NCI-H929 MM tumors in vivo.

, 2016
(A) Regression of very large (median volume = 730 mm3) subcutaneous NCI-H929 MM tumors in 8–12 week old CB.17 SCID mice (n = 8 per group) that were treated twice weekly for 3 weeks with 10 mg/kg of anti-CD38-IFNα(att) or vehicle. (B) Tumor volumes of the
James Berenson (3111285), Anthony Doyle (577129), Yong Yun (3111264), Haiming Chen (355433), David S. Wilson (36463), Maya Sokolovsky (3111255), Moti Rosenstock (3111276), Eric Sanchez (3111288), Tetsuya Taura (3111270), Steffen Nock (3111279), Collette Behrens (3111261), Angela Sho (3111273), Sarah L. Pogue (3111267), Hussein Hallak (3019602), Mingying Bi (3111258), Glen Mikesell (3111282)   +15 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source