Results 51 to 60 of about 67,119 (304)
CD38 and Anti-CD38 Monoclonal Antibodies in AL Amyloidosis: Targeting Plasma Cells and beyond [PDF]
International Journal of Molecular Sciences, 2020 Immunoglobulin light chain amyloidosis (AL amyloidosis) is a rare systemic disease characterized by monoclonal light chains (LCs) depositing in tissue as insoluble fibrils, causing irreversible tissue damage. The mechanisms involved in aggregation and deposition of LCs are not fully understood, but CD138/38 plasma cells (PCs) are undoubtedly involved ...
Dario Roccatello +8 more
openaire +2 more sources
, 2016 Two assays were used to evaluate the antigen specificity of anti-CD38 targeted IFNα’s. The graphs on the left show viability assays of treated ARP-1 MM cells three days after incubation with IFNα compounds.
James Berenson (3111285) +15 more
core +1 more source
Expanding anti-CD38 immunotherapy for lymphoid malignancies
, 2022 BACKGROUND: Lymphoid neoplasms, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and NK/T cell neoplasms, are a major cause of blood cancer morbidity and mortality.
Wang, Xu +10 more
core +1 more source
Daratumumab induces CD38 internalization and impairs myeloma cell adhesion
OncoImmunology, 2018 Daratumumab (Dara), a human immunoglobulin G1 kappa (IgG1κ) monoclonal anti-CD38 antibody, has been approved by the U.S. Food and Drug Administration for the treatment of relapsed multiple myeloma (MM) as a single agent as well as in combination with ...
Jayeeta Ghose +17 more
doaj +1 more source
Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapse [PDF]
Blood, 2008 AbstractDuring immunologic synapse (IS) formation, human CD38 redistributes to the contact area of T cell–antigen-presenting cell (APC) conjugates in an antigen-dependent manner. Confocal microscopy showed that CD38 preferentially accumulated along the contact zone, whereas CD3-ζ redistributed toward the central zone of the IS.
Muñoz, Pilar +9 more
openaire +4 more sources
, 2016 (A) Regression of very large (median volume = 730 mm3) subcutaneous NCI-H929 MM tumors in 8–12 week old CB.17 SCID mice (n = 8 per group) that were treated twice weekly for 3 weeks with 10 mg/kg of anti-CD38-IFNα(att) or vehicle. (B) Tumor volumes of the
James Berenson (3111285) +15 more
core +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening
Advanced Science, EarlyView.Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun +6 more
wiley +1 more source
, 2016 (A) Inhibition of subcutaneous MM NCI-H929 tumor growth in 8–12 week old CB.17 SCID mice (n = 10 per group) that were treated twice weekly for 4 weeks with anti-CD38-IFNα(att) or naked anti-CD38 antibody (both at 10 mg/kg), native IFNα (0.4 mg/kg), or ...
James Berenson (3111285) +15 more
core +1 more source
Advanced Science, EarlyView.Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao +25 more
wiley +1 more source