Results 61 to 70 of about 67,119 (304)

Role of Anti-CD38 Monoclonal Antibodies in the Treatment of Adult Immune Hematological Diseases

Hematology/Oncology and Stem Cell Therapy
Daratumumab is a first-in-class human anti-CD38 IgG1 monoclonal antibody approved for treating newly diagnosed and relapsed refractory multiple myeloma. Pre-clinical data supported daratumumab's ability to deplete autoantibodies producing plasma cells, B-
Erin H. Yang, Ibrahim N. Muhsen, Hadeel Samarkandi, Riad El Fakih, Mahmoud Aljurf, Amr Hanbali   +5 more
doaj   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Daratumumab (anti-CD38) induces loss of CD38 on red blood cells [PDF]

Blood, 2017
To the editor: The recently approved anti-CD38 monoclonal antibody daratumumab (DARA) provides a unique therapeutic strategy that more selectively targets plasma cells in patients with plasma cell myeloma.[1][1][⇓][2][⇓][3][⇓][4][⇓][5]-[6][6] While DARA recognizes and removes ...
Harold C. Sullivan, Christian Gerner-Smidt, Ajay K. Nooka, Connie M. Arthur, Louisa Thompson, Amanda Mener, Seema R. Patel, Marianne Yee, Ross M. Fasano, Cassandra D. Josephson, Richard M. Kaufman, John D. Roback, Sagar Lonial, Sean R. Stowell   +13 more
openaire   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Interference of daratumumab with compatibility testing in blood bank

Global Journal of Transfusion Medicine, 2019
Plasma cell myeloma accounts for 1% of malignant tumors and 10%–15% of hematopoietic neoplasms. Daratumumab (DARA), a novel targeted immunotherapy drug, was approved by the Food and Drug Administration to treat relapsed/refractory multiple myeloma. DARA,
Rani Premkumar, Siva Deepthi
doaj   +1 more source

T-Cell Immune Imbalance in Rheumatoid Arthritis Is Associated with Alterations in NK Cells and NK-Like T Cells Expressing CD38

Journal of Innate Immunity, 2021
Background: CD38+ NK (CD3− CD16+ CD38+ CD56+) cells were increased in rheumatoid arthritis (RA), which suppressed Treg cell differentiation. This study explored how CD38+ NK cells regulated CD4+ T-cell differentiation into Treg cells in RA.
Hongxing Wang, Kehua Fang, Weining Yan, Xiaotian Chang   +3 more
doaj   +1 more source

Catalysis-based inhibitors of the calcium signaling function of CD38

, 2011
CD38 is a signaling enzyme responsible for catalyzing the synthesis of cyclic ADP ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate; both are universal Ca(2+) messenger molecules.
Hao, Q, Chen, Z, Connie Mo Ching Lam, Fung Ping Leung, Zhang, LH, Lee, HC, Li-He Zhang, Lam, Connie Mo Ching, Quan Hao, Chen, Zhe, Leung, FP, Anna Ka Yee Kwong, Lee, Hon Cheung, Zhang, Liangren, Kwong, Anna Ka Yee, HongMin Zhang, Hon Cheung Lee, Ting, Kai Yiu, Zhang, Li-He, Ting, KY, Zhang, HongMin, Hao, Quan, Zhang, L, Leung, Fung Ping, Zhe Chen, Lam, CMC, Kwong, AKY, Zhang, H, Liangren Zhang, Kai Yiu Ting   +29 more
core   +1 more source

Современные представления о роли CD38 в патогенезе бронхиальной астмы

, 2013
Current view on a role of CD38 for pathogenesis of bronchial asthma.Современные представления о роли CD38 в патогенезе бронхиальной ...
I. V. Demko, A. Yu. Kraposhina, I. A. Solovyeva, И. А. Соловьева, И. В. Демко, Е. А. Собко, А. Ю. Крапошина, А. Б. Салмина, A. B. Salmina, E. A. Sobko   +9 more
core   +1 more source

The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta‐Analysis of the European Myeloma Network (EMN)

American Journal of Hematology, EarlyView.
Our meta‐analysis showed significant improvement of PFS with lenalidomide, proteasome inhibitors, and CD38‐based therapies. A significant OS benefit was noted only with lenalidomide in transplant‐eligible (TE) patients, while CD38‐directed therapy showed a trend toward improved OS.
Heinz Ludwig, Evangelos Terpos, Francesca Gay, Niels W. C. J. van de Donk, Sarah Bernhard, Monika Engelhardt, Gordon Cook, Fredrik Schjesvold, Hermann Einsele, Graham Jackson, Charlotte Pawlyn, María‐Victoria Mateos, Sonja Zweegman, Martin Schreder, Meral Beksaç, Christoph Driessen, Enrique M. Ocio, Rakesh Popat, Leo Rasche, Cyrille Touzeau, Pellegrino Musto, Annemiek Broijl, Meletios Dimopoulos, Roman Hajek, Mario Boccadoro, Pieter Sonneveld   +25 more
wiley   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source