Results 81 to 90 of about 92,020 (286)

NK cells and CD38: Implication for (Immuno)Therapy in Plasma Cell Dyscrasias

Cells, 2020
Immunotherapy represents a promising new avenue for the treatment of multiple myeloma (MM) patients, particularly with the availability of Monoclonal Antibodies (mAbs) as anti-CD38 Daratumumab and Isatuximab and anti-SLAM-F7 Elotuzumab.
Renato Zambello, Gregorio Barilà, Sabrina Manni, Francesco Piazza, Gianpietro Semenzato   +4 more
doaj   +1 more source

Granulocytic myeloid-derived suppressor cells increased in early phases of primary HIV infection depending on TRAIL plasma level [PDF]

, 2017
Background It has been demonstrated that Myeloid Derived Suppressor Cells (MDSC) are expanded in HIV-1 infected individuals and correlated with disease progression.
Abbate, Isabella, Agrati, Chiara, Ammassari, Adriana, Antinori, Andrea, BILOTTA, MARIA TERESA, Bordoni, Veronica, CAPOBIANCHI, Maria Rosaria, Casetti, Rita, Cimini, Eleonora, Martini, Federico, Pinnetti, Carmela, Sacchi, Alessandra, Tumino, Nicola, Turchi, Federica   +13 more
core   +1 more source

Anti-CD38 autoantibodies in type? diabetes

Diabetes/Metabolism Research and Reviews, 2006
Human diabetes mellitus comprises two main clinical entities: type 1 and type 2 diabetes. While type 1 diabetes is autoimmune in origin, type 2 diabetes is due to a decreased sensitivity to insulin action (so-called insulin resistance) associated with impaired beta cell function.
MALLONE R, CAVALLO PERIN, Paolo
openaire   +5 more sources

Cd38/Adp-Ribosyl Cyclase [PDF]

The Journal of Cell Biology, 1999
The multifunctional ADP-ribosyl cyclase, CD38, catalyzes the cyclization of NAD+ to cyclic ADP-ribose (cADPr). The latter gates Ca2+ release through microsomal membrane-resident ryanodine receptors (RyRs). We first cloned and sequenced full-length CD38 cDNA from a rabbit osteoclast cDNA library.
Li Sun, Olugbenga A. Adebanjo, Baljit S. Moonga, Susanne Corisdeo, Hindupur K. Anandatheerthavarada, Gopa Biswas, Toshiya Arakawa, Yoshiyuki Hakeda, Antoliy Koval, Bali Sodam, Peter J.R. Bevis, A. James Moser, F. Anthony Lai, Solomon Epstein, Bruce R. Troen, Masayoshi Kumegawa, Mone Zaidi   +16 more
openaire   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Immunotherapies targeting CD38 in Multiple Myeloma [PDF]

OncoImmunology, 2016
Recently, the monoclonal antibody daratumumab was approved as a single agent for the treatment of patients with relapsed/refractory Multiple Myeloma (MM). Daratumumab is an antibody targeting surface molecule CD38 on myeloma cells and the agent is already widely being used based on its good tolerability and proven efficacy.
Djordje, Atanackovic, Mary, Steinbach, Sabarinath Venniyil, Radhakrishnan, Tim, Luetkens   +3 more
openaire   +2 more sources

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

Cryptochrome-1 Gene Expression is a Reliable Prognostic Indicator in Egyptian Patients with Chronic Lymphocytic Leukemia: A Prospective Cohort Study

Turkish Journal of Hematology, 2018
Objective: Traditional prognostic factors have proved insufficient to account for heterogeneity in the clinical behavior of chronic lymphocytic leukemia (CLL). Cryptochrome-1 (CRY-1) is a circadian clock gene essential in maintaining the circadian rhythm
Deena Mohamed Habashy, Deena Samir Eissa, Mona Mahmoud Aboelez   +2 more
doaj   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

OPPORTUNITIES OF FLOW CYTOMETRY IN DIAGNOSTICS OF INFECTIOUS DISEASES. Part 2

Инфекция и иммунитет, 2014
. Flow cytometry allows estimating quantitative and qualitative structure of populations and subpopulations of immune system cells by using various methodical approaches and a wide spectrum of reagents.
S. V. Khaidukov, A. V. Zurochka
doaj   +1 more source