Results 91 to 100 of about 58,391 (264)

Tp53 Genetic Mutations in Chronic Lymphocytic Leukemia Patients in Iraq

Journal of Applied Hematology
Background: Chronic lymphocytic leukemia (CLL) is a malignant clonal proliferative condition of mature CD5+ B cells, with a 4.2/100,000 annual incidence rate and the median age at diagnosis is 72 years.
Kareem Abed Mobashr, Liqaa Mohammed Al Sharifi, Afraa Mahdi Jawad   +2 more
doaj   +1 more source

Prospective Head‐To‐Head Comparison of a 10‐Color Single‐Tube Flow Cytometry and EuroFlow Next‐Generation Flow in Multiple Myeloma Minimal Residual Disease

Journal of Clinical Laboratory Analysis, EarlyView.
We compared a 10‐color single‐tube (ST‐10C) assay with the EuroFlow next‐generation flow (NGF) method for detecting minimal residual disease (MRD) in multiple myeloma. The ST‐10C assay showed substantial qualitative agreement, strong quantitative correlation, and comparable progression‐free survival stratification relative to the EuroFlow NGF assay ...
Go Eun Bae, Dae Jin Lim, Sung Hoan Bang, Suhng‐Wook Kim, Ari Ahn, Hee‐Jin Kim, Jun Ho Yi, Kihyun Kim, Duck Cho, Hyun‐Young Kim   +9 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Evaluation of CD38 and CD138 as Diagnostic Markers in the Pathologic Diagnosis of Chronic Endometritis

Clinical and Experimental Obstetrics & Gynecology
Background:Chronic endometritis (CE) is a prevalent gynecological disorder and a major cause of female infertility. However, clearly defined clinical or histopathological diagnostic criteria for CE are still lacking.
Xishan Chen, Jiexiong Huang, Xiaowei Luo, Liangli Hong, Qiancheng Qiu, Shuiqin Lin, Bin Wang   +6 more
doaj   +1 more source

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Immunophenotypic Characterization of Patients with Chronic Lymphocytic Leukemia by Flow Cytometry; Association with Disease Prognosis

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Chronic lymphocytic leukemia (CLL) is characterized by clonal proliferation and accumulation of long-lived B lymphocytes within the peripheral blood, bone marrow, and secondary lymphoid organs.
Esmaeil Allahmoradi, Saeid Taghiloo, Ghasem Janbabaei, Ramin Shekarriz, Mohsen Tehrani, Hossein Asgarian-Omran   +5 more
doaj  

Interference and treatment strategy of a novel anti-CD38 antibody—mezagitamab in pre-transfusion test

Zhongguo shuxue zazhi
[Objective] To investigate the specific interference of the novel anti-CD38 antibody mezagitamab in pretransfusion testing, establish an immunomagnetic bead pre-treatment method to eliminate it, and evaluate its impact on other blood group systems and ...
WEI Hua, REN Dongxia, ZHAO Jingya, MU Shijie, YANG Longfei   +4 more
doaj   +1 more source

CD38 as a prognostic marker in CLL

Hematology, 2005
Cell-surface expression of CD38 in CLL has been recognised recently as a marker of progressive disease and poor outcome. In contrast to traditional staging systems, CD38 is able to identify progressive cases at an early stage. Measurement of CD38, in conjunction with other novel prognostic factors such as p53 and ZAP-70 helps to identify patients who ...
openaire   +2 more sources

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

The Role of Nicotinamide Adenine Dinucleotide in the Pathogenesis of Rheumatoid Arthritis: Potential Implications for Treatment

European Medical Journal, 2018
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, autoimmune disease characterised by small joint swelling, deformity, and dysfunction. Its exact aetiology is unclear.
Weiqian Chen, Caihong Yi, Lin Jin
doaj