Results 111 to 120 of about 67,119 (304)

Essential role of CD38 in platelet aggregation through the PKC- mediated internalization and activation [PDF]

BioImpacts
Introduction: CD38 is a multifunctional enzyme with a potent Ca2+ mobilizing effect, cyclic ADP-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP).
Mazhar Mushtaq, Maira Mahmood, Uzma Jabbar, Uh-Hyun Kim   +3 more
doaj   +1 more source

CD38 regulates hHSC division.

(A) Gating strategy for isolation of human HSCs and LT-HSCs. (B) Representative immunofluorescence intracellular staining of human cells and quantification of CD38 integrated fluorescence intensity (n = 43/63/31 for CD38- CD34+, CD38+ CD34+, CD38++ CD34-,
Anupam Sinha (1974100), Andreas Dahl (2696749), Tatyana Grinenko (18078786), Malte von Bonin (400911), Juan Alberto Pérez-Valencia (18078780), Sema Elif Eski (10899813), Manja Wobus (326146), Liliia Ibneeva (18078774), Susanne Reinhardt (7824746), Martin Bornhäuser (219605), Sumeet Pal Singh (10899822), Alexander Gerbaulet (558872), Iryna Kovtun (18078777), Ben Wielockx (13181916), Jaime Sancho (329189), Marc Schmitz (357415), Rebekka Wehner (357414), Frances Lund (18078783), Triantafyllos Chavakis (5816888), Luise Rupp (15167618)   +19 more
core   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Expression of mRNA CD16A, CD16B, ICAM1, CD38, FOXP3 in tumor tissue of patients with clear cell renal cell carcinoma

Медицинская иммунология
Diagnosis of kidney cancer presents significant difficulties, since symptoms of the disease may appear only at an advanced stage. Special attention is paid to the search for biomarkers that allow for rapid and effective tumor diagnosis and disease ...
Z. V. Amoev, A. V. Alyasova, D. V. Novikov, O. O. School, S. G. Selivanova, A. V. Kalugin, V. V. Novikov   +6 more
doaj   +1 more source

Molecular Characterization of a Novel Intracellular ADP-Ribosyl Cyclase

, 2007
Background. ADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Jonathan S Marchant, Marchant, JS, Michael J Boulware, Dev Churamani, Churamani, D, Dale, L, Geach Timothy J., Martin Andrew C.R., Gary W Moy, Andrew C R Martin, Sandip Patel, Dale Leslie, Yi-Hsien Su, Vacquier, VD, Vacquier Victor D., Su, YH, Patel Sandip, Churamani Dev, Boulware, MJ, Marchant Jonathan S., Leslie Dale, Boulware Michael J., Moy Gary W., Patel, S, Geach, TJ, Su Yi-Hsien, Moy, GW, Timothy J Geach, Martin, ACR, Victor D Vacquier   +29 more
core   +1 more source

Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer

Molecular & Cellular Oncology, 2017
While chronic inflammation has been causally associated with several epithelial malignancies, whether it causally contributes to the development of prostate cancer has remained unclear.
Preston D. Crowell, Andrew S. Goldstein
doaj   +1 more source

Crystal structure of human CD38 extracellular domain

, 2005
Human CD38 is a multifunctional protein involved in diverse functions. As an enzyme, it is responsible for the synthesis of two Ca2+ messengers, cADPR and NAADP; as an antigen, it is involved in regulating cell adhesion, differentiation, and ...
Graeff, Richard, Hao, Q, Munshi, Cyrus, Kriksunov, IA, Liu, Q, Hon, CL, Lee, Hon Cheung, Graeff, R, Irina A. Kriksunov, Munshi, C, Richard Graeff, Hon Cheung Lee, Liu, Qun, Hao, Quan, Kriksunov, Irina A., Quan Hao, Cyrus Munshi, Qun Liu   +17 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Studies of CD38 in chronic lymphocytic leukaemia [PDF]

This Thesis consists of 4 experimental Chapters preceded by a General Introduction and followed by a brief section dealing with conclusions and future.
Matrai, Zoltan.
core   +1 more source

The Growth Supporting Role of ZDHHC11 Is Linked to the MEF2B–BCL6 Regulatory Circuit in Burkitt Lymphoma

International Journal of Cancer, EarlyView.
MEF2B and BCL6 have established functions in germinal center B‐cell biology and lymphomagenesis. The mechanism of MEF2B deregulation and its significance for cell survival in Burkitt lymphoma however remain unclear. This study highlights MEF2B as a crucial transcription factor in Burkitt lymphoma and suggests ZDHHC11 as an upstream regulator of MEF2B ...
Lotteke J. Y. M. Ziel‐Swier, Karolina Rassek, Yichen Liu, Annika Seitz, Jasper Koerts, Debora de Jong, Bea Rutgers, Anastasiia Kompaniiets, Julia Przybył, Martine E. D. Chamuleau, Anke van den Berg, Agnieszka Dzikiewicz‐Krawczyk, Joost Kluiver   +12 more
wiley   +1 more source