Results 241 to 250 of about 67,119 (304)

Mesenteric Adipose Tissue as a Modulator of Intestinal Inflammation: Mechanistic Insights and Model Systems in Crohn's Disease

European Journal of Immunology, Volume 56, Issue 6, June 2026.
This review explores how mesenteric adipose tissue, particularly creeping fat, contributes to intestinal inflammation through dysregulated adipokine signalling. We explore how metabolic stress alters immune‐adipose interactions and promotes disease progression.
Toka Omar, Carl Weidinger, Britta Siegmund   +2 more
wiley   +1 more source

High-Risk Cytogenetic Multiple Myeloma Remains a Therapeutic Challenge: A 15-Year Real-World Analysis. [PDF]

Curr Oncol
Awadallah C, Zayad A, Atrash S, Mazloom A, Alkharabsheh O, Mewawalla P, Shah MR, Lutfi F, Mahmoudjafari Z, Umair Mushtaq M, Kort J, Habib A, Abdallah AO.   +12 more
europepmc   +1 more source

CRISPR/Cas9‐Mediated Gene Knockout Reveals a Nonredundant Role for p16INK4A in Controlling TCR‐Dependent and Independent CD8 T Cell Expansion

European Journal of Immunology, Volume 56, Issue 6, June 2026.
Ex vivo characterization of antigen‐specific CD8 T cells is crucial but often limited by expansion bottlenecks. We identify p16INK4A as a key regulator of TCR‐dependent and homeostatic proliferation. CRISPR/Cas9 deletion of CDKN2A rescues proliferation and improves IFN‐γ secretion while maintaining TCR‐dependency, enabling robust expansion for ...
Silvia Fiori, Cecilia Adragna, Emilia Malvicini, Tommaso Basini, Donatella Galgano, Edoardo Scarpa, Sandra Jovic, Niklas A. Schmacke, Veit Hornung, Federica Sallusto, Ludovica Bruno, Antonio Lanzavecchia, Manuel Albanese   +12 more
wiley   +1 more source

Regulating the regulators via targeting CD38 in the tumor microenvironment. [PDF]

Front Immunol
Dutta N, Halder N, Chini EN, Kim S, Manna A.   +4 more
europepmc   +1 more source

Cytogenetic and Molecular Analysis of a “Double‐Hit” RUNX1 Including a RUNX1 p.Trp279* and a Cryptic Novel t(6;21)(q25;q22)/RUNX1::ARID1B in Acute Myeloid Leukemia

Genes, Chromosomes and Cancer, Volume 65, Issue 6, June 2026.
ABSTRACT Introduction Alterations involving RUNX1 are recurrent in hematologic malignancies and contribute to disease pathogenesis via dysregulation of transcriptional factors essential for hematopoiesis. Here, we report an acquired alteration in both alleles of RUNX1; one is a truncating mutation and the second is a novel RUNX1::ARID1B identified in ...
Rolando García, Jing Xu, Lan Yu, Kalayarasan Srinivasan, Sharon Koorse Germans, Olga Weinberg, Franklin Fuda, Weina Chen, Prasad Koduru   +8 more
wiley   +1 more source

Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes. [PDF]

Glia
Basak S, Colafrancesco AM, Hernandez RD, Wei X, McMeekin LJ, Dang D, Simmons M, Browning JL, Noel K, Zhou F, Lund FE, Saad JS, Watsen SG, Pickrell AM, Cowell RM, Olsen ML.   +15 more
europepmc   +1 more source

Clinical outcomes of mitochondrial‐enhancing nutraceutical supplementation in psychiatric disorders: A systematic review

General Psychiatry, Volume 39, Issue 3, June 2026.
ABSTRACT Background Nutraceutical supplementation targeting mitochondrial function has been proposed as a beneficial therapeutic strategy to improve physical and mental health in psychiatric patients. Aims To summarise the results of studies evaluating nutraceutical supplementation targeting mitochondrial function in patients with psychiatric disorders.
Juan Tortajada, Bengisu Kevser Bulduk, Belén Alfonso‐Landete, Paula Alcaide‐Barriga, Bernat Ballvé‐Gelonch, Glòria Garrabou, Elisabet Vilella, Yolanda Alonso, Alba Valiente‐Pallejà, Lourdes Martorell   +9 more
wiley   +1 more source

CD38 degrades MAVS through mitophagy to inhibit type I interferon secretion in nasopharyngeal carcinoma cells and impairs CD8⁺T cell-mediated anti-tumor immunity. [PDF]

Nat Commun
Liang L, Li W, Liu S, He Q, Zeng F, Cao J, Lei Y, Li Y, Zhou Y.   +8 more
europepmc   +1 more source

Teclistamab in relapsed/refractory light chain amyloidosis: A retrospective multicenter study by the German Society for Amyloid Diseases

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Systemic light chain (AL) amyloidosis is a rare, acquired protein misfolding disorder characterized by extracellular deposition of misfolded immunoglobulin light chain fibrils, resulting in organ damage. Treatment is based on anti‐plasma cell regimens derived from multiple myeloma therapy.
Alexander Carpinteiro, Christoph Kimmich, Despina Trajanova, Ute Hegenbart, Timon Hansen, Udo Holtick, Vera von Landenberg‐Roberg, Stephan Rainer Bohl, Raphael Teipel, Ivana von Metzler, Monika Engelhardt, Evgenii Shumilov, Maximilian Steinhardt, Hans Christian Reinhardt, Sara Oubari, Stefan Schönland   +15 more
wiley   +1 more source

Anti-CD38 Therapy With Daratumumab in High-Risk IgA Nephropathy. [PDF]

Kidney Int Rep
Poux M, De Vriese AS, Cohen C, Duong Van Huyen JP, Daugas E, Jolivot A, Joher N, Matignon M, Hertig A, El Karoui K.   +9 more
europepmc   +1 more source