Results 81 to 90 of about 91,544 (273)

Anti-CD38 autoantibodies in type? diabetes

Diabetes/Metabolism Research and Reviews, 2006
Human diabetes mellitus comprises two main clinical entities: type 1 and type 2 diabetes. While type 1 diabetes is autoimmune in origin, type 2 diabetes is due to a decreased sensitivity to insulin action (so-called insulin resistance) associated with impaired beta cell function.
MALLONE R, CAVALLO PERIN, Paolo
openaire   +5 more sources

Cd38/Adp-Ribosyl Cyclase [PDF]

The Journal of Cell Biology, 1999
The multifunctional ADP-ribosyl cyclase, CD38, catalyzes the cyclization of NAD+ to cyclic ADP-ribose (cADPr). The latter gates Ca2+ release through microsomal membrane-resident ryanodine receptors (RyRs). We first cloned and sequenced full-length CD38 cDNA from a rabbit osteoclast cDNA library.
Li Sun, Olugbenga A. Adebanjo, Baljit S. Moonga, Susanne Corisdeo, Hindupur K. Anandatheerthavarada, Gopa Biswas, Toshiya Arakawa, Yoshiyuki Hakeda, Antoliy Koval, Bali Sodam, Peter J.R. Bevis, A. James Moser, F. Anthony Lai, Solomon Epstein, Bruce R. Troen, Masayoshi Kumegawa, Mone Zaidi   +16 more
openaire   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Immunotherapies targeting CD38 in Multiple Myeloma [PDF]

OncoImmunology, 2016
Recently, the monoclonal antibody daratumumab was approved as a single agent for the treatment of patients with relapsed/refractory Multiple Myeloma (MM). Daratumumab is an antibody targeting surface molecule CD38 on myeloma cells and the agent is already widely being used based on its good tolerability and proven efficacy.
Djordje, Atanackovic, Mary, Steinbach, Sabarinath Venniyil, Radhakrishnan, Tim, Luetkens   +3 more
openaire   +2 more sources

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Granulocytic myeloid-derived suppressor cells increased in early phases of primary HIV infection depending on TRAIL plasma level [PDF]

, 2017
Background It has been demonstrated that Myeloid Derived Suppressor Cells (MDSC) are expanded in HIV-1 infected individuals and correlated with disease progression.
Abbate, Isabella, Agrati, Chiara, Ammassari, Adriana, Antinori, Andrea, BILOTTA, MARIA TERESA, Bordoni, Veronica, CAPOBIANCHI, Maria Rosaria, Casetti, Rita, Cimini, Eleonora, Martini, Federico, Pinnetti, Carmela, Sacchi, Alessandra, Tumino, Nicola, Turchi, Federica   +13 more
core   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source

Phenotype and function of NK cell in colorectal cancer

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To investigate the composition of immune cells in tumor microenvironment of colorectal cancer (CRC), and examine the proportion, phenotype and effector function of natural killer (NK) cells in CRC.Methods·Fresh tumor tissues, paired normal ...
FENG Xujiao, LIU Jianyue, QI Yangyang, SUN Jing, SHEN Lei   +4 more
doaj   +1 more source

Overcoming Drug Interference in Transfusion Testing: A Spotlight on Daratumumab

Journal of Blood Medicine, 2021
Marilyn T Nedumcheril,1,2 Robert A DeSimone,1 Sabrina E Racine-Brzostek,1 Ok Kyong Chaekal,1,3 Ljiljana V Vasovic1 1Department of Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA; 2New York ...
Nedumcheril MT, DeSimone RA, Racine-Brzostek SE, Chaekal OK, Vasovic LV   +4 more
doaj  

Subpopulations of mobilized hematopoietic stem cells in patients with hematological malignances and donors: expression of CD38, HLA-DR and CD143

Онкогематология, 2019
The study objective is to investigate the features of subpopulational composition of mobilized hematopoietic stem cells in peripheral blood (PB) and leukocyte concentrates (LC) in adult patients with oncohematological pathology and donors.Materials and ...
M. L. Kanaeva, I. V. Galtseva, E. N. Parovichnikova, Yu. O. Davydova, T. V. Gaponova, E. O. Gribanova, Ya. V. Balzhanova, L. A. Kuzmina, V. V. Troitskaya, S. K. Kravchenko, E. E. Zvonkov, L. P. Mendeleeva, V. G. Savchenko   +12 more
doaj   +1 more source