Results 181 to 190 of about 575,439 (264)

Ligature-induced periodontitis in mice potentially accelerates CD4⁺ T-cell senescence and exacerbates rheumatoid arthritis. [PDF]

Front Immunol
Li J, Sanui T, Shida M, Yotsumoto K, Ahmad M, Wang Z, Xiao M, Hayashi C, Shinjo T, Taketomi T, Fukuda T, Nishimura F.   +11 more
europepmc   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

<i>Lactobacillus rhamnosus</i> GG Alleviates Colitis by SLC5A12-Mediated Th17/Treg Cell Balance in Mice. [PDF]

Nutrients
Zhang Y, He X, Zhao Q, Duan Q, Li H, Qin R, Zuo W, Xie K, Han B.   +8 more
europepmc   +1 more source

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

PD1⁺ TIGIT⁺ CD4⁺ T cells predict response to anti-TNF in rheumatoid arthritis and spondyloarthritis. [PDF]

RMD Open
Bitoun S, Roulleaux-Dugage M, Naigeon M, de Oliveira C, Berthot C, Mariette X, Nocturne G, Chaput N.   +7 more
europepmc   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

CD4⁺ T cell count mediates the association between gut microbiota and diabetic kidney disease progression. [PDF]

Front Cell Infect Microbiol
Zheng X, Zhu Y, Cui W, Wang Z, Xia C, Zhi Y, Shang J, Zhao Z.   +7 more
europepmc   +1 more source

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Peroxisomal ABCD1 deficiency in mice drives Th1 bias through 25-HC-LXR signaling in CD4⁺ T cells. [PDF]

Front Immunol
Maeda R, Oishi M, Nagamori R, Hikosaka-Kuniishi M, Watanabe S, Lee JB, Morita M, So T.   +7 more
europepmc   +1 more source