Results 201 to 210 of about 575,439 (264)

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

Impact of SARS-CoV-2 Breakthrough Infection on Short-Term CD4 Count Among Adults With HIV in the United States From 2020 to 2022. [PDF]

Open Forum Infect Dis
Hopkins L, Humes E, Gordon KS, Marconi VC, Lang R, Horberg MA, Napravnik S, Silverberg MJ, Browne LE, Park LS, Gebo KA, Agil DM, Althoff KN, Coburn SB.   +13 more
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Type-1 inflammatory imprinting and programmed responsiveness to CD40L enhance Siglec-1-dependent HIV-1 trans-infection by dendritic cells. [PDF]

Front Immunol
Bothwell EG, DePuyt AE, Zaccard CR, Anderko RR, Shoucair PEJ, Bilben HA, Garcia-Bates TM, Gerberick AD, Watkins SC, Sluis-Cremer N, Rinaldo CR, Mailliard RB.   +11 more
europepmc   +1 more source

CD73 activity controls cytotoxic CD4 T-cell response driving myocardial pathology in chronic Chagas disease. [PDF]

Front Immunol
Bergero G, Mazzocco YL, Cejas Gallardo ZM, Rivarola W, Del Rosso S, Aoki MP.   +5 more
europepmc   +1 more source

Long-acting IL-7 restores T-cell reconstitution in a humanized mouse model of lymphopenia. [PDF]

J Allergy Clin Immunol
Pérez-Díez A, Liu X, Bennett A, Barrios M, Anderson M, Wolfarth AA, Choi D, Lisco A, Sereti I.   +8 more
europepmc   +1 more source

Machine learning risk stratification to identify people living with HIV at high risk of delayed ART and advanced immunosuppression: a precision public health approach. [PDF]

Front Public Health
Yin J, Li T, Jin J, Chen J, Ba H, Zhang Y, Li J, Liu H, Ma K.   +8 more
europepmc   +1 more source

Single-cell T-cell landscape in atherosclerosis: implications for targeted therapy and beyond. [PDF]

J Transl Med
Luo R, Liu S, Ouyang X, Zhou E, Jiang L.
europepmc   +1 more source

Profound immune suppression and exhaustion characterize refractory mycoplasma pneumoniae pneumonia in children. [PDF]

Front Immunol
Ma X, Wu Y, He F, Yao H, Cao L, Zhu C.
europepmc   +1 more source