Results 31 to 40 of about 276,570 (260)

Atypical CD3+ CD4(low) cell population in a boy with fatal EBV-infection [PDF]

, 1999
A previously healthy 10-year-old Greek boy born to nonconsanguineous healthy parents developed progressive liver disease after acute infectious mononucleosis.
Krauss-Etschmann, Susanne, Belohradsky, Bernd H., Gruber, Rudolf, Jäger, Gundula, Koletzko, Sibylle   +4 more
core   +1 more source

Effect of pembrolizumab on CD4+CD25+, CD4+LAP+ and CD4+TIM-3+ T cell subsets [PDF]

Clinical and Experimental Immunology, 2019
Summary Tumor immune evasion involves the expansion of avidly proliferating immunosuppressive cells and inhibition of effector T cell proliferation. Immune checkpoints (IC) block the activation pathways of tumor-reactive T cells. IC pathways are often exploited by tumor cells to evade immune destruction, and blocking these pathways ...
S M Toor, V Sasidharan Nair, G Pfister, E Elkord   +3 more
openaire   +2 more sources

CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms [PDF]

, 2003
Copyright @ 2003 The Rockefeller University PressCD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved.
Fiona Powrie, Maloy, Kevin J., Gordon Dougan, Powrie, Fiona, Dougan, Gordon, Laurence Salaun, Cahill, R, Saunders, NJ, Saunders, Nigel J., Nigel J. Saunders, Salaun, L, Powrie, F, Rachel Cahill, Kevin J. Maloy, Salaun, Laurence, Maloy, KJ, Dougan, G, Cahill, Rachel   +17 more
core   +1 more source

Comparative Analysis of Conformational Dynamics and Systematic Characterization of Cryptic Pockets in the SARS-CoV-2 Omicron BA.2, BA.2.75 and XBB.1 Spike Complexes with the ACE2 Host Receptor: Confluence of Binding and Structural Plasticity in Mediating Networks of Conserved Allosteric Sites

Viruses, 2023
In the current study, we explore coarse-grained simulations and atomistic molecular dynamics together with binding energetics scanning and cryptic pocket detection in a comparative examination of conformational landscapes and systematic characterization ...
Mohammed Alshahrani, Grace Gupta, Sian Xiao, Peng Tao, Gennady Verkhivker   +4 more
doaj   +1 more source

CD4+count-guided interruption of antiretroviral treatment [PDF]

, 2006
BACKGROUND:Despite declines in morbidity and mortality with the use of combination antiretroviral therapy, its effectiveness is limited by adverse events, problems with adherence, and resistance of the human immunodeficiency virus (HIV).METHODS:We ...
Babiker, A, Lundgren, JD, Faetkenheuer, G., Rappoport, C, Hoy, Jennifer, El-Sadr, Wafaa, Arduino, RC, Grund, B, Abrams, DJ, Clumeck, Nathan, Strategies for Management of Antiretroviral Therapy (SMART) Stud, Clumeck, N., Gazzard, B, Neuhaus, J, Neaton, J. D., Lundgren, J. D., Darbyshire, J, Grund, Birgit, Hoy, J., Phillips, A., Fätkenheuer, Gerd, Neaton, James, Lundgren, Jens D, Cohn, D., Cohen, C. J., Mejia, JMR, Strategies Management Antiretrovir, Darbyshire, J., Emery, S, Klingman, Karin, Darbyshire, Janet, Markowitz, Norman, Emery, Sean, Cohn, David V., Cooper, David, Gordin, Fred, Emery, S., Losso, M, Losso, Marcello, Klingman, K, Neaton, JD, Clumeck, N, Markowitz, N., Babiker, Abdel, Cooper, D., Losso, M., Mejia, J. M. Ramos, Arduino, R. C., Gordin, F, Fatkenheuer, G, Cohen, Calvin, Hoy, J, Neuhaus, J., El-Sadr, W. M., Grund, B., Klingman, K., El-Sadr, WM, Cohn, D, Gazzard, Brian, Burman, William, Burman, W., Abrams, D, Cohen, CJ, Gazzard, B., Arduino, Roberto, Markowitz, N, Gordin, F., Babiker, A., Burman, W, Cooper, D, Abrams, D., Phillips, Andrew N., Phillips, A, Rappoport, C.   +73 more
core   +1 more source

Effects of fermented Crescentia cujete L. on the profile of haematology, clinical chemistry and circulatory CD4+/CD8+ in Sprague Dawley rats

Open Veterinary Journal
Background: The calabash (Crescentia cujete L.) is a tropical fruit that offers numerous health benefits. Its fermented form (FC) has been found to affect the neurological system positively.
Agustina Dwi Wijayanti, Yos Adi Prakoso, Krestel Joy Viernes Isla   +2 more
doaj   +1 more source

Modulation of CD4 by suramin [PDF]

Clinical and Experimental Immunology, 1993
SUMMARYSuramin is a polysulphonated compound which can selectively bind to, and inhibit the activity of, a wide range of growth factors. There has been renewed interest recently in suramin as an anti-cancer agent and therefore we have studied its effects on lymphocyte subset populations and recombinant human IL-2 (rhIL-2) activation on lymphocytes in ...
P D, Allen, D H, Johnston, M G, Macey, N S, Williams, A C, Newland   +4 more
openaire   +2 more sources

HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy [PDF]

, 2008
We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258
Battegay, Manuel, Günthard, Huldrych F, Gaudieri, S., Swiss, HIV Cohort Study, John, Mina, Nolan, David, James, Ian, Furrer, H, Schmid, P, Battegay, M., McKinnon, E, Rauch, A., Swiss HIV Cohort Study, ., McKinnon, E., Telenti, A, Günthard, Huldrych F., Schmid, Patrick, Rauch, A, John, M., James, I, Furrer, Hansjakob, Hirschel, Bernard, Telenti, Amalio, Schmid, P., Furrer, H., Rauch, Andri, John, M, Günthard, H.F., Mallal, Simon, Telenti, A., McKinnon, Elizabeth, Nolan, D., Günthard, H F, Hirschel, B, Günthard, H. F., Battegay, M, Hirschel, B., Nolan, D, Mallal, S, James, I., Gaudieri, Silvana, Mallal, S., Gaudieri, S, John M, Battegay M, James I, Nolan D, Gaudieri S, Rauch A, Mallal S, Schmid P, Telenti A, Furrer H, McKinnon E, Hirschel B, Günthard HF   +55 more
core   +2 more sources

Analysis Activity of Elephantopus scaber Leaves Extract Against Quantitative Changes of Lymphocytes Cells in BALB/c Mice After Induction of DMBA and Estrogen

Journal of Experimental Life Science, 2019
The carcinogenic compounds such as DMBA known for having the ability to promote the DNA damage that affects the growth regulator genes. Therefore, uncontrolled cell growth will occur and change the immune system. Elephantopus scaber extract is considered
Lailiyavina Rochmatika, Sri Widyarti, Muhammad Sasmito Djati   +2 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source