Results 71 to 80 of about 727,847 (314)

IL-10 from CD4(+)CD25(-)Foxp3(-)CD127(-) adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection [PDF]

, 2008
The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite replication, whilst failure to ...
Couper, Kevin N, Hafalla, Julius C, Riley, Eleanor M, Daniel G. Blount, Eleanor M Riley, Blount, Daniel G., Kevin N Couper, Richard A Flavell, Wilson, MS, de Souza, J Brian, Daniel G Blount, Mark S Wilson, Couper, KN, Blount, DG, Kamanaka, Masahito, Wilson, Mark S, Julius C. Hafalla, Belkaid, Yasmine, Masahito Kamanaka, Blount, Daniel G, Flavell, Richard A, Flavell, Richard A., J. Brian de Souza, Flavell, RA, De Souza, J. Brian, Kevin N. Couper, Kamanaka, M, Hafalla, Julius C., Julius C Hafalla, Eleanor M. Riley, Hafalla, JC, Riley, Eleanor M., Belkaid, Y, Yasmine Belkaid, De Souza, JB, Mark S. Wilson, Richard A. Flavell, Couper, Kevin N., Wilson, Mark S., Riley, EM, J Brian de Souza   +40 more
core   +1 more source

Relationship between CD4 count and CD4% in HIV-infected people [PDF]

International Journal of Epidemiology, 1997
To describe the relationship between absolute CD4 count and CD4%, and the influence on this of gender, risk group, age, a diagnosis of AIDS, use of zidovudine (ZDV) therapy and PCP prophylaxis.9203 paired serial measurements of CD4 count and CD4% on 1017 initially AIDS-free and ZDV-naive HIV positive patients from a London-based cohort were available ...
L M, Yu, P J, Easterbrook, T, Marshall
openaire   +2 more sources

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Rapid turnover of effector-memory CD4(+) T cells in healthy humans [PDF]

, 2004
Memory T cells can be divided into central-memory (T(CM)) and effector-memory (T(EM)) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not known whether they are maintained by similar ...
Peter C.L. Beverley, Macallan, DC, Griffin, GE, George E. Griffin, Andrew T. Worth, Derek C. Macallan, Wallace, Diana, Diana Wallace, Ghattas, Hala, Zhang, Yan, Griffin, George E, Macallan, Derek C, Beverley, Peter, Zhang, Y, Ghattas, H, Beverley, Peter CL, Tough, David F, Hala Ghattas, Tough, DF, David F. Tough, De Lara, C, De Lara, Catherine, Beverley, PC, Yan Zhang, Catherine de Lara, Wallace, D, Worth, Andrew T, Worth, AT   +27 more
core   +1 more source

Cross-linking of CD4 induces cytoskeletal association of CD4 and p56lck [PDF]

Experimental & Molecular Medicine, 2000
A membrane glycoprotein CD4 functions as a co-receptor of a T lymphocyte. The co-receptor function has been attributed to a protein tyrosine kinase, p56lck, which is activated upon CD4 binding to MHC molecule. In this study, we present evidences that one of the pathways through which CD4 transmits its signal is cytoskeleton association of p56lck ...
Y M, Ha-Lee, Y, Lee, Y K, Kim, J, Sohn
openaire   +2 more sources

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy

, 2008
We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258
Battegay, Manuel, Günthard, Huldrych F, Gaudieri, S., Swiss, HIV Cohort Study, John, Mina, Nolan, David, James, Ian, Furrer, H, Schmid, P, Battegay, M., McKinnon, E, Rauch, A., Swiss HIV Cohort Study, ., McKinnon, E., Telenti, A, Günthard, Huldrych F., Schmid, Patrick, Rauch, A, John, M., James, I, Furrer, Hansjakob, Hirschel, Bernard, Telenti, Amalio, Schmid, P., Furrer, H., Rauch, Andri, John, M, Günthard, H.F., Mallal, Simon, Telenti, A., McKinnon, Elizabeth, Nolan, D., Günthard, H F, Hirschel, B, Günthard, H. F., Battegay, M, Hirschel, B., Nolan, D, Mallal, S, James, I., Gaudieri, Silvana, Mallal, S., Gaudieri, S   +42 more
core   +2 more sources

Low CD4/CD8 Ratio Is Associated with Non AIDS-Defining Cancers in Patients on Antiretroviral Therapy: ANRS CO8 (Aproco/Copilote) Prospective Cohort Study. [PDF]

PLoS ONE, 2016
OBJECTIVES:To study the association between CD4/CD8 ratio and morbidity in HIV-infected patients on antiretroviral therapy (ART). METHODS:The APROCO/COPILOTE cohort enrolled patients initiating a protease inhibitor-containing ART in 1997-1999.
Mariam Noelie Hema, Tristan Ferry, Michel Dupon, Lise Cuzin, Renaud Verdon, Rodolphe Thiébaut, Camelia Protopopescu, Catherine Leport, François Raffi, Vincent Le Moing, ANRS CO 8 (APROCO/COPILOTE) study group   +10 more
doaj   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source