Advanced Science, EarlyView.Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu +14 more
wiley +1 more source
Immunological characteristics in patients with HIV/AIDS of the municipality of Regla, Havana
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020 Background: acquired immunodeficiency syndrome (AIDS) is the final stage in human immunodeficiency virus (HIV) infection. Knowing the immune status of the patients infected with the virus permits a better treatment.Objective: to characterize ...
Jorge Torres-Concepción +1 more
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Antiretroviral Cytolytic T-Lymphocyte Nonresponsiveness: FasL/Fas-Mediated Inhibition of CD4+and CD8+Antiviral T Cells by Viral Antigen-Positive Veto Cells [PDF]
, 1999 Robert F. Rich, William R. Green
openalex +1 more source
Loss of NR2F6 Protects from Salmonella Typhimurium Infection
Advanced Science, EarlyView.Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk +8 more
wiley +1 more source
Preoperative counts of CD4 T-lymphocytes and early postoperative infective complications in HIV-positive patients [PDF]
, 2002 D Savioz +8 more
openalex +1 more source
Advanced Science, EarlyView.Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui +19 more
wiley +1 more source
The Antiviral Efficacy of the Murine Alpha-1 Interferon Transgene against Ocular Herpes Simplex Virus Type 1 Requires the Presence of CD4+, α/β T-Cell Receptor-Positive T Lymphocytes with the Capacity To Produce Gamma Interferon [PDF]
, 2002 Daniel J.J. Carr, Sansanee Noisakran
openalex +1 more source
Potentiating the Efficacy of mRNA Vaccines through NIR‐II Imaging‐Guided Precise Vaccination
Advanced Science, EarlyView.A supramolecular strategy is utilized to integrate IR780‐C16 lipids into conventional LNPs, pioneering a novel NIR‐II‐LNPs platform that elucidates the correlations between mRNA vaccines efficacy and vaccination parameters in a non‐invasive approach.
Mengfei Li +6 more
wiley +1 more source
Expression of genes encoding cytotoxic cell-associated serine proteases in thymocytes [PDF]
, 2017 A family of homologous serine esterases designated granzyme A-H and the pore-forming protein perforin are present in cytoplasmic granules of mature peripheral cytolytic T lymphocytes and natural killer cells.
Held, Werner +2 more
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