Results 211 to 220 of about 314,352 (325)

T-Cell Prolymphocytic Leukaemia With Isolated Pulmonary Manifestation. [PDF]

Respirol Case Rep
Kobayashi Y, Tomioka H, Sakai R, Goto H.
europepmc   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

5-ALA Assisted Surgery of Human Glioblastoma Samples Reveals an Enrichment of T Cells Expressing PD-1 and CD103 in the Intermediate and Marginal Layers. [PDF]

Eur J Immunol
Vanni A, Matani F, Bonaudo C, Mazzoni A, Capone M, Lamacchia G, Salvati L, Bartoli L, Francalanci S, Petti M, Capelli F, Nozzoli F, Cosmi L, Liotta F, Della Puppa A, Maggi L, Annunziato F.   +16 more
europepmc   +1 more source

Age‐dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double‐positive CD4⁺ CD8⁺ cells and B220⁺ T cells, in mice

, 2004
Yuiko Ishimoto, Chikako Tomiyama‐Miyaji, Hisami Watanabe, Hisashi Yokoyama, Kazuto Ebe, Shunsuke Tsubata, Yutaka Aoyagi, Toru Abo   +7 more
openalex   +2 more sources

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis

Advanced Science, EarlyView.
Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu, Ning Liang, Chen Wu, Zhaoyan Qiu, Qian Huang, Xiaolong Wei, Shurong Zhang, Shuanghong Lei, Tao Yang, Gang Wang, Qian Wang   +10 more
wiley   +1 more source

Distinct Roles of HHLA2 and PD-L1 in the Immune Cell and Prognosis of Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Wang CH, Chen SL, Yang X, Wu T, Liu LL, Yun JP.   +5 more
europepmc   +1 more source

Ex vivo EXPANSION AND CHARACTERIZATION OF EPSTEIN-BARR VIRUS-SPECIFIC CD4-POSITIVE BULK CYTOTOXIC T LYMPHOCYTES

, 2004
漆原 範子, 山田 淑子, Tôru Miyazaki, 山口 美樹, 村橋 秀明, 関本 達也, Shin Sato, Hiroshi Azuma, 秋野 光明, 池田 久實   +9 more
openalex   +2 more sources

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

Advanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu, Danming He, Zan Hou, Mei Lan, Ye Zhang, Qifeng Wang   +5 more
wiley   +1 more source

Dysregulation of immune cells and platelet-monocyte aggregates in chronic thromboembolic pulmonary hypertension. [PDF]

Respir Res
Sun L, Li H, Li X, Li Y, Liu M, Tian H, Liu J, Miao R, Zhang Y, Huang Q, Zhang Z, Niu X, Zhang S, Xie W, Xu S, Yang P, Zhai Z.   +16 more
europepmc   +1 more source

HLA‐DR⁺ Tumor Cells Show an Association with a Distinct Immune Microenvironment and CD8⁺ T‐Cell Exhaustion in HBV‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang, Yan Guo, Wen‐Jing Yuan, Yu‐Man Chen, Bo‐Wei Liu, Wen‐Tao Li, Xiang‐Ming Ding, Xu‐Dong Fu, Yu‐Han Lou, Zhuo‐Ran Chen, Xiao‐Ying Luo, Song‐Ze Ding, Bing‐Yong Zhang, Xiu‐Ling Li, Yong‐Zhi Hong, Shun‐Dong Cang, Dong‐Xiao Li, Ling Lan   +17 more
wiley   +1 more source