Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics [PDF]
Cancer is a complex mechanism involving a series of cellular events. The glycoproteins such as hyaluronan (HA) are a significant element of extracellular matrix (ECM), involve in the onset of cancer developmental process.
Gul-e-Saba Chaudhry+5 more
doaj +2 more sources
CD44 and EPCAM expression in pleomorphic adenoma and mucoepidermoid carcinoma: An immunohistochemical method. [PDF]
Background: Recent studies have indicated that assessing the expression levels of cancer stem cell markers is critical in predicting the behavior of these neoplasms.
Maleki L+4 more
europepmc +2 more sources
Comparative characteristic of lung cancer stem-like cells generated in vitro under different culture conditions [PDF]
Cancer stem cells (CSCs) play an important role in resistance to cancer treatment and recurrence developing. The aim of this study was to obtain cell culture of MOR line non-small cell lung cancer cells enriched in CSCs and to investigate its functional ...
O. V. Skachkova+4 more
doaj +1 more source
Mutant Allele of CD44 (rs8193C>T) and Pum2 Regulatory Element as A Prognosis Factor of Prostate Neoplasms: A Case-Control and In Silico Studies [PDF]
ObjectiveExpression of CD44 variant 6 (CD44v6) as a homing-associated cell adhesion molecule (HCAM), hasproved to change most cancer cells. Aim of the study is the effect of mutant allele of CD44 (rs8193C>T) and Pum2regulatory element as a prognosis ...
Mohammadkazem Heydari+2 more
doaj +1 more source
CD44: A Multifunctional Mediator of Cancer Progression
CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess several CSC traits, such as self-renewal and epithelial-mesenchymal transition
Malak Hassn Mesrati+3 more
semanticscholar +1 more source
CD44-Targeted Nanocarrier for Cancer Therapy
Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in varieties of solid tumors including pancreatic, breast, ovary, brain, and lung cancers.
Prashant Kesharwani+4 more
semanticscholar +1 more source
CD44 is a prognostic biomarker and correlated with immune infiltrates in gastric cancer
Objective Gastric carcinoma is the most common malignant tumour of the human digestive system worldwide. CD44 serves as a marker for several tumour stem cells, including gastric cancer.
Weiyan Hou+3 more
semanticscholar +1 more source
CD44 was once thought to simply be a transmembrane adhesion molecule that also played a role in the metabolism of its principal ligand hyaluronan. Investigations of CD44 over the past ∼20 yr have established additional functions for CD44, including its capacity to mediate inflammatory cell function and tumor growth and metastasis.
Joanna Cichy, Ellen Puré, Ellen Puré
openaire +3 more sources
CD44 related stemness maneuvers oral squamous cell carcinoma biology
Introduction: Despite the commendable advancements in oral squamous cell carcinoma (OSCC) diagnostics and therapeutics, it remains a considerable medical challenge. Recent evidence suggests that small populations of stem-like cancer cells are responsible
Ankita Tandon+2 more
doaj +1 more source
The state of CD44 activation in cancer progression and therapeutic targeting
CD44, a non‐kinase transmembrane glycoprotein, is ubiquitously expressed on various types of cells, especially cancer stem cells (CSCs), and has been implicated in cancer onset and aggressiveness.
Qian Guo, Cuixia Yang, F. Gao
semanticscholar +1 more source