Results 151 to 160 of about 136,526 (307)

CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line [PDF]

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. Cancer stem cells (CSCs) have attracted attention as a novel therapeutic target for cancer because they play important roles in the development and aggravation of ...
40790374, 00403402, Makimoto, Kazuki, ツチヤ, ヒロユキ, 100001095, Asai, Ryoma, 70263457, 坂部, 友彦, アミサキ, マサタカ, 100000303, Koyama, Shigemi, 土谷, 博之, Shiota, Goshi, 4866, 95, 網崎, 正孝, Takenaga, Ai, 50639747, シオタ, ゴウシ, 3099, 汐田, 剛史, Sakabe, Tomohiko, 26382, 26381, 26384, 26383, 100001720, 3368, Tsuchiya, Hiroyuki, Hoi, Shotaro, Amisaki, Masataka, サカベ, トモヒコ, 26380   +32 more
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Slug-based epithelial-mesenchymal transition gene signature is associated with prolonged time to recurrence in glioblastoma

, 2011
Background We previously identified a precise stage-associated gene expression signature of coordinately expressed genes, including the transcription factor Slug (SNAI2) and other epithelial mesenchymal transition (EMT) markers, present in ...
Jessica J. Kandel, Peter Canoll, Darrell J. Yamashiro, Wei-Yi Cheng, Dimitris Anastassiou   +4 more
core  

A study on the increased CD44 expression in primary meningioma

【背景と⽬的】髄膜腫は原発性脳腫瘍のうち約30%を占める最も⼀般的な腫瘍である。髄膜腫の⼤部分は世界保健機関 (World Health Organization: 以下 WHO)グレード 1 の良性腫瘍であり、外科的切除によって治癒が可能であるが、ときに腫瘍周囲脳浮腫（peritumoral brain edema; 以下 PTBE）を伴い、重篤な場合には神経脱落症状を呈したり、てんかん発作の原因となったりすることで治療に難渋することがある。CD44 ...
澤谷, 亮佑
core   +1 more source

CD44 regulates astrocyte morphology.

, 2016
A: Validation of CD44shRNA and CD44-GFP constructs. Astrocytes were transfected with pSuper, CD44shRNA or CD44-GFP constructs (together with β-actin-GFP plasmid) and then immunostained with anti-CD44 antibody (red).
Grzegorz M. Wilczynski (231452), Andre Zeug (780003), Franziska Mueller (1518526), Anna Konopka (576487), Beata Kaza (2741797), Joanna Dzwonek (2741803), Agnieszka Chwedorowicz (2741800), Evgeni Ponimaskin (780002), Anna Skupien (2741794)   +8 more
core   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Cadmium nanocluster as a safe nanocarrier: biodistribution in BALB/c mice and application to carry crocin to breast cancer cell lines

Exploration of Targeted Anti-tumor Therapy
Aim: Metal nanoclusters are emerging nanomaterials applicable for drug delivery. Here, the toxicity and oxidative stress induction of divalent cationic cadmium (Cd2+) was compared with a Cd in the form of nanocluster.
Moslem Jafarisani, S. Ali Hashemi, Nassim Faridi, Mir F. Mousavi, S. Zahra Bathaie   +4 more
doaj   +1 more source

CD44/CD24 expression in human breast cancer.

, 2013
A, DAPI; B, DAPI and CD24 (red); C, DAPI and CD44 (green); D, merged images. The composite image (D) shows the heterogeneity of CD44 and CD24 expression.
Mariagiovanna Zagami (307721), Daniele Santini (222870), Andrea Onetti Muda (222931), Francesca Nasorri (307722), Vittorio Altomare (307726), Giuseppe Perrone (222909), Roberto Coppola (307723), Andrea Cavani (307728), Giuseppe Tonini (222938), Francesco Bartolozzi (307725), Lucio Trodella (307727), Laura Maria Gaeta (307720), Domenico Borzomati (307724)   +12 more
core   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source