Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu+5 more
wiley +1 more source
The β<sub>2</sub>-adrenergic receptor (<i>Adrb2</i>) entrains circadian gene oscillation and CD8<sup>+</sup> T cell differentiation in response to virus infection. [PDF]
Sharma D+3 more
europepmc +1 more source
Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine
A glucose‐catalyzed chemodynamic strategy is proposed to activate therapeutic genome editing of SMARCAL1to improve cancer immunotherapy. This innovative design featuring Fenton reaction activity and glucose consumption ability, not only effectively synergizes to activate the cGAS‐STING pathway but also inhibits the opposing functions of interferon by ...
Yuwei Li+8 more
wiley +1 more source
CD44 mediates the internalization of foot-and-mouth disease virus through macropinocytosis. [PDF]
Wang X+5 more
europepmc +1 more source
Hyaluronan-dependent motility of B cells and leukemic plasma cells in blood, but not of bone marrow plasma cells, in multiple myeloma: alternate use of receptor for hyaluronan-mediated motility (RHAMM) and CD44 [PDF]
A Masellis-Smith+4 more
openalex +1 more source
Schwann cells may facilitate intracranial plaque progression via neurovascular remodelingcting with vascular smooth muscle cells in atherosclerotic plaques, with the SPP1 ‐ ITGB1 signaling axis mediating this interaction as a novel mechanism. Abstract Intracranial atherosclerosis (ICAS), a common cause of ischemic stroke, remains a therapeutic ...
Zijue Wang+10 more
wiley +1 more source
Identification of Two Distinct Stem Cell Clusters, Lrig1-Derived and Wnt/CD44-Dependent, in Corneal Epithelium. [PDF]
Barnes L+4 more
europepmc +1 more source
Expression of CD44 Variants and Its Association with Survival in Pancreatic Cancer [PDF]
Takuji Gotoda+7 more
openalex +1 more source