Results 201 to 210 of about 229,337 (378)

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

Correlations of Cancer Stem Cell-Related Markers CD44+/CD24-/low and ALDH1 Expression in Breast Cancer and Its Significance [PDF]

, 2014
Yajun Fu, Juanying Zhu, Xiaohong Jiang, Peng Ren, Xiongying Zhang, Guangtao Xu   +5 more
openalex   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Localisation and endocrine control of hyaluronan synthase (HAS) 2, HAS3 and CD44 expression in sheep granulosa cells [PDF]

, 2016
A. A. Fouladi-Nashta, Adamia, Allegrucci, Baerwald, Bodevin-Authelet, Camenisch, Campbell, Campbell, Deroo, El Maradny, Erickson, Fortune, Freudenberger, G. M. Hartshorne, Galluzzo, Hall, Hettinger, Hunter, Itano, Itano, Itano, Jacob, Jain, Juengel, Koehler, Kosaki, Kultti, Laurent, Lee, Luo, Manna, Marei, Marei, Marzioni, Miyake, Miyake, Moriarty, Necas, Nykopp, Nykopp, Ohta, Ohta, Perry, Perry, Pettersson, R. Chavoshinejad, Raheem, Rilla, Robinson, Sainio, Saito, Scaramuzzi, Schoenfelder, Silva, Stern, Tempel, Tienthai, Toole, Toole, Toole, Tsonis, Ulbrich, W. F. A. Marei, Watson, Weigel, Zhao   +65 more
core   +1 more source

Hyaluronan and CD44 in epidermis with special reference to growth factors and malignant transformation (Kasvutekijöiden ja syövän vaikutus epidermiksen hyaluronaaniin ja CD44:ään)

, 2020
Susanna Hartmann-Petersen
openalex   +1 more source

Synthesis and characterization of CD44 targeted nanoparticle PEI/pDNA/HA-mPEG for gene delivery [PDF]

, 2016
Tiantian Wang, Mingxing Liu, Honghao Sun
openalex   +1 more source

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Histochemical structure and immunolocalisation of the hyaluronan system in the dromedary oviduct [PDF]

, 2015
Abdel-Aleem A. El-Saba, Abe, Accogli, Ali A. Fouladi-Nashta, Apichela, Aruffo, Avil�s, Bergqvist, Buhi, Crater, Csoka, Dougherty, Edelstam, Hawk, Ismail, Itano, Lepperdinger, Lesley, Marei, Marei, McCourt, Menezo, Menzel, Nieder, Ohno-Nakahara, Omnia Mohey-Elsaeed, Parrish, Ponglowhapan, Prehm, Raheem, Shimada, Skidmore, Skidmore, Spicer, Srikandakumar, Stern, Stern, Teixeira Gomes, Termeer, Tienthai, Tienthai, Tienthai, Toole, Toyokawa, Ulbrich, Underhill, Waleed F. A. Marei, Wang, Weigel, Whittingham, Xu   +50 more
core   +2 more sources

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source