Results 221 to 230 of about 145,654 (260)

CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration. [PDF]

Nat Cell Biol
Jha A, Chandra A, Farahani PE, Toettcher JE, Pasapera AM, Haugh JM, Waterman CM.   +6 more
europepmc   +1 more source

Programmable three‐state nanoreactor for spatiotemporally controlled tumor therapy

BMEMat, EarlyView.
The OMVs are shielded with a biocompatible Da–Ca shell, which prolongs its circulation period and promotes intratumoral accumulation. Importantly, the biocompatible Da–Ca shell can be controllably disintegrated in tumor microenvironment by using laser irradiation, generating in situ hyperthermia and releasing Ca2+.
Guihong Lu, Peng Ye, Xiaoyan Li, Ke Ma, Chengliang Lyu, Kai Zhang, Ran Luo, Yang Ji, Shiqi Mei, Fan Zhang, Jinxie Zhang, Lin Mei, Hui Tan   +12 more
wiley   +1 more source

Oral nano-delivery of a gut microbial metabolite enhances T cell stemness for cancer immunotherapy. [PDF]

Nat Nanotechnol
Han K, Cho YS, Takahashi M, Zhou X, Dobson HE, Hutchings K, Wu Y, Na Y, Xie F, Crowther J, Wu J, Xu J, Lee C, Jasewicz H, Kim Y, Nenwani M, Animasahun O, Wuchu F, Andren A, Wong H, Camp E, Wan Z, Wu Q, Zhang L, Xu C, Dong K, Xu Y, Schwendeman A, Chen GY, Xie Y, Lyssiotis CA, Clasby M, Nagrath D, Lei YL, Moon JJ.   +34 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

CD44-Hyaluronan-Dependent Monocyte Rolling. [PDF]

Int J Mol Sci
Hubbe M, Eibl RH.
europepmc   +1 more source

Dual‐targeted nanomedicine delivering doxorubicin and nitric oxide for tumor immunomodulation and synergistic therapy

BMEMat, EarlyView.
The mechanism of HA‐DS@PLGA nanoparticles co‐delivering DOX and SNAP (an NO donor) to suppress tumor growth, remodel the tumor microenvironment, and enhance antitumor immune responses for effective combinatorial cancer therapy. Abstract Cancer therapeutic efficacy is significantly influenced by tumor immunosuppressive environment possibly induced by ...
Xingzhou Peng, Wei Chen, Shuyu Li, Xiaomin Ma, Yanfeng Dai, Yan Wang, Changqiang Xie, Yazhe Xiao, Hesong Han, Yumiao Zhang, Junjie Wang   +10 more
wiley   +1 more source

Sulfotransferase signaling sustains fibroblast identity and antagonizes therapeutic cardiac reprogramming. [PDF]

Nat Commun
Romero MR, Murphy S, Chang YL, Lamba A, Ancel S, Llorente A, Marchant J, Huang CT, Kumsta C, Andersen P, Ranade S, Mahmoud AI, Kwon C, Freeze HH, Adams PD, Sacco A, Ranek MJ, Emerling BM, Wang YX, Colas AR.   +19 more
europepmc   +1 more source

Caveolin‐1 enriched apoptotic bodies derived from oral hard palate orchestrate bone remodeling to treat heterotopic ossification

BMEMat, EarlyView.
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang, Like Tang, Zhou Yu, Wenjin Cai, Qifeng Jiang, Zhikang Wang, Yitong Chen, Kaichen Lai, Ying Wang, Tim Forouzanfar, Chiyuan Ma, Gang Wu, Tingben Huang, Guoli Yang   +13 more
wiley   +1 more source

C1q-CD44 interactions regulate microglial phagocytosis, proliferation, and migration. [PDF]

J Neuroinflammation
Sakthivel PS, Villegas AJ, Lakatos A, Kaipa M, Lopez JM, Ling A, Elrachid ZH, Karam J, Anderson AJ.   +8 more
europepmc   +1 more source