Results 141 to 150 of about 18,936 (283)

Intrinsic NLRP3 inflammasome activity is critical for normal adaptive immunity via regulation of IFN-γ in CD4+ T cells [PDF]

, 2016
The NLRP3 inflammasome controls interleukin-1b maturation in antigen-presenting cells, but a direct role for NLRP3 in human adaptive immune cells has not been described.We found that the NLRP3 inflammasome assembles in human CD4+ Tcells and ...
A. A. B. Robertson, A. Klos, A. P. Cope, A. Sher, Arend, B. Afzali, Bock, C. Kemper, C. Rheinheimer, Cardone, Dinarello, Dowling, E. E. West, G. Arbore, Ghannam, H. J. Lachmann, J. Kohl, K. D. Mayer-Barber, L. A. ONeill, Le Friec, M. A. Cooper, M. Arno, Martinon, Mayer-Barber, Menu, Murphy, Okamura, P. Dutow, P. Monk, Pontillo, Powell, R. C. Coll, R. Spolski, Rao, Ricklin, Schroder, Scola, Shaw, Strainic, Sutton, T. M. Woodruff, Vogel, W. J. Leonard, Woodruff, Z. X. Yu, Zielinski   +45 more
core   +3 more sources

Analysis of meteorological data from RRS Charles Darwin cruises CD46 and CD47 (BOFS experiment) [PDF]

, 1993
The IOSDL MultiMet meteorological instrumentation system was used during the BOFS experiment on RRS Charles Darwin cruises 46 and 47. This report describes and evaluates the quality of the meteorological data obtained.
Birch, K.G., Pascal, R.W., Taylor, P.K., Tiddy, R.J.   +3 more
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Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia

Advanced Science, Volume 12, Issue 10, March 13, 2025.
Immune thrombocytopenia (ITP) is an autoimmune disorder marked by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. It is found that the lectin pathway of the complement system, resistin, MIF, and AA metabolism may serve as promising targets for ...
Jin Li, Xiaoqian Wang, Yaoyao Chen, Xianlei Sun, Liyan Fu, Qingxuan Xin, Huilin Zhang, Bo Qin, Nannan Sun, Yingmei Li, Yan Xu, Hui Yang, Dawei Huo, Yong Dong, Shuya Wang, Mengyun Zhao, Quande Lin, Fang Wang, Baohong Yue, Yanxia Gao, Yong Jiang, Rongqun Guo   +21 more
wiley   +1 more source

Altered Expression of Complement Regulatory Proteins CD35, CD46, CD55, and CD59 on Leukocyte Subsets in Individuals Suffering From Coronary Artery Disease

Frontiers in Immunology, 2019
Studies conducted in animal models have suggested that membrane complement regulatory proteins play an important role in the pathophysiology of coronary artery disease (CAD).
N. Mishra, Madhav Mohata, R. Narang, R. Lakshmy, A. Hazarika, R. Pandey, N. Das, K. Luthra   +7 more
semanticscholar   +1 more source

Transient Removal of CD46 Is Safe and Increases B-cell Depletion by Rituximab in CD46 Transgenic Mice and Macaques

Molecular Therapy, 2013
We have developed a technology that depletes the complement regulatory protein (CRP) CD46 from the cell surface, and thereby sensitizes tumor cells to complement-dependent cytotoxicity triggered by therapeutic monoclonal antibodies (mAbs). This technology is based on a small recombinant protein, Ad35K++, which induces the internalization and subsequent
Douglas R Woodle, Zong-Yi Li, Diane Rocha, Hongjie Wang, Michael Gough, Ronald Manger, Darrick Carter, Ying Liu, Ronald J. Berenson, Audrey Baldessari, Jaclyn Bogue, Roma Yumul, Jonas Persson, André Lieber, Hua Cao, Ines Beyer, Ines Beyer   +16 more
openaire   +3 more sources

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]

, 2015
Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC, Gjertson, D, Mulder, A, Panicker, S, Parry, GC, Reed, EF, Thomas, KA, Valenzuela, NM   +7 more
core   +1 more source

Dysregulated CD46 shedding interferes with Th1‐contraction in systemic lupus erythematosus

European Journal of Immunology, 2017
IFN‐γ‐producing T helper 1 (Th1) cell responses mediate protection against infections but uncontrolled Th1 activity also contributes to a broad range of autoimmune diseases. Autocrine complement activation has recently emerged as key in the induction and
U. Ellinghaus, A. Cortini, C. Pinder, G. Le Friec, C. Kemper, T. Vyse   +5 more
semanticscholar   +1 more source

Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status. [PDF]

, 2007
Am J Pathol. 2007 Sep;171(3):893-905. Epub 2007 Aug 3. Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status.
Adams, Alexander Marx, Angela Vincent, Aurea Canelhas, B. Paul Morgan, Beeson, Berrih, Castleman, Cole, Dashiell, Daveau, Davies, Drachman, Engel, Erik Niks, Evoli, Flores, Fosbrink, Francesco Scaravilli, French, Gasque, Graus, Hageman, Hoch, Hsi, Jan J.G.M. Verschuuren, Kaminski, Kaminski, Kyewski, Lampert, Lauriola, Leite, Lin, MacLennan, MacLennan, Margaret Jones, Maria I. Leite, Mason, Matthews, McConville, Meraouna, Monsinjon, Morgan, Morgan, Morgan, Nakano, Navenot, Nick Willcox, Ohta, Philipp Ströbel, Plested, Pratt, Ralf Gold, Roxanis, Roxanis, Rus, Safar, Sanders, Schluep, Schluep, Shiono, Sims, Sonia Berrih-Aknin, Spreadbury, Sprott, Tzartos, van Beek, Vincent, Vincent, Wakkach, Wekerle, Zhang   +71 more
core   +2 more sources

Relative Contribution of Cellular Complement Inhibitors CD59, CD46, and CD55 to Parainfluenza Virus 5 Inhibition of Complement-Mediated Neutralization

Viruses, 2018
The complement system is a part of the innate immune system that viruses need to face during infections. Many viruses incorporate cellular regulators of complement activation (RCA) to block complement pathways and our prior work has shown that ...
Yujia Li, G. Parks
semanticscholar   +1 more source

Basic and translational studies on species B adenoviruses [PDF]

, 2012
Human adenoviruses (Ads) have been classified into six species (A to F) currently containing 55 serotypes. For almost 2 decades vectors derived from group C serotype Ad5 have been extensively used for gene transfer studies.
Wang, Hongjie
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