Results 31 to 40 of about 17,628 (245)
Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile [PDF]
, 2013 <p>Background: Cardiovascular disorders, including coronary artery bypass graft failure and in-stent restenosis remain significant opportunities for the advancement of novel therapeutics that target neointimal hyperplasia, a characteristic of both ...
AA Soyombo +47 more
core +2 more sources
A C3(H20) recycling pathway is a component of the intracellular complement system [PDF]
, 2017 An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores
Botto +11 more
core +2 more sources
Viral Traits and Cellular Knock-Out Genotype Affect Dependence of BVDV on Bovine CD46
Pathogens, 2021 The role of bovine CD46 in the host cell entry of BVDV has been established for more than a decade. By generating novel MDBK CD46 knock-out clones, we confirm previously reported data on the CD46 motives important for BVDV binding and the importance of ...
Hann-Wei Chen +6 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2009 Background In rodents, the cell surface complement regulatory protein CD46 is expressed solely on the spermatozoal acrosome membrane. Ablation of the CD46 gene is associated with a faster acrosome reaction.
Flanagan Brian F +7 more
doaj +1 more source
CD46-Mediated costimulation induces a Th1-biased response and enhances early TCR/CD3 signaling in human CD4+ T lymphocytes [PDF]
, 2004 10 páginas, 8 figuras -- PAGS nros. 2439-2448The role of membrane cofactor protein (MCP, CD46) on human T cell activation has been analyzed. Coligation of CD3 and CD46 in the presence of PMA or CD28 costimuli enhanced IL-2, IFN-γ, or IL-10 secretion by ...
Feito, María José +2 more
core +2 more sources
Инфекция и иммунитет, 2023 The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to global morbidity and mortality. Some patients fully recover from COVID-19, whereas around 45% subjects suffer from various persistent symptoms (fatigue, cognitive impairment, impaired ...
Maria A. Dobrynina +6 more
doaj +1 more source
CD46 processing: A means of expression [PDF]
Immunobiology, 2012 CD46 is a ubiquitously expressed type I transmembrane protein, first identified as a regulator of complement activation, and later as an entry receptor for a variety of pathogens. The last decade has also revealed the role of CD46 in regulating the adaptive immune response, acting as an additional costimulatory molecule for human T cells and inducing ...
Ni Choileain, Siobhan, Astier, Anne
openaire +4 more sources
CD46 protects the bladder cancer cells from cetuximab-mediated cytotoxicity
Scientific Reports, 2022 Epidermal growth factor receptor (EGFR) is an effective target for those patients with metastatic colorectal cancers that retain the wild-type RAS gene. However, its efficacy in many cancers, including bladder cancer, is unclear.
Manh-Hung Do +5 more
doaj +1 more source
Potential benefits and risks of clinical xenotransplantation [PDF]
, 2012 The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core +2 more sources
Wavelet feature extraction and genetic algorithm for biomarker detection in colorectal cancer data [PDF]
, 2012 Biomarkers which predict patient’s survival can play an important role in medical diagnosis and treatment. How to select the significant biomarkers from hundreds of protein markers is a key step in survival analysis.
Aickelin, Uwe +3 more
core +3 more sources