Results 41 to 50 of about 18,453 (236)

Structure of Bovine CD46 Ectodomain

Viruses, 2023
CD46, or membrane cofactor protein, is a type-one transmembrane protein from the complement regulatory protein family. Alongside its role in complement activation, CD46 is involved in many other processes, from T-cell activation to reproduction.
Hazel Aitkenhead, David I. Stuart, Kamel El Omari   +2 more
doaj   +1 more source

CD46 Isoforms Influence the Mode of Entry by Human Herpesvirus 6A/B in T Cells

Journal of Virology, 2022
CD46 is the receptor used by human herpesvirus 6A (HHV-6A) during infection of T cells, but it is also involved in infection of certain T cells by HHV-6B. The gene for CD46 allows expression of several variants of CD46, known as isoforms, but whether the
L. Rossen, Vivien R. Schack, K. Thuesen, B. Bundgaard, P. Höllsberg   +4 more
semanticscholar   +1 more source

Porcine Complement Regulatory Protein CD46 Is a Major Receptor for Atypical Porcine Pestivirus but Not for Classical Swine Fever Virus

Journal of Virology, 2021
Pestiviruses comprise animal pathogens such as classical swine fever virus (CSFV) and bovine viral diarrhea virus (BVDV) that cause notifiable diseases with great economic impact.
Gökce Nur Cagatay, A. Antos, Oliver Suckstorff, O. Isken, N. Tautz, P. Becher, A. Postel   +6 more
semanticscholar   +1 more source

Inhibition of cd46 receptor by rnai enhances cell resistance to bvdv infection [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020
This study aimed to investigate the inhibition effect of CD46 on the replication of bovine viral diarrhea viruses (BVDV). BVDV causes bovine viral diarrheal mucosal disease, and prevention of BVDV infection is very important for livestock production ...
Ruirui HU, Liang FENG, Tao GUO, Rui YAO, Yaxin LI, Xiaokui WANG, Taotao MI, Shengwei HU   +7 more
doaj   +1 more source

Ex Vivo and In Vivo CD46 Receptor Utilization by Species D Human Adenovirus Serotype 26 (HAdV26)

bioRxiv, 2021
The human species D Ad26 is being investigated as a low-seroprevalence vector for oncolytic virotherapy and gene-based vaccination against HIV-1 and SARS-CoV-2.
Jack R. Hemsath, A. Liaci, J. Rubin, Brian J. Parrett, Shao-Chia Lu, Tien V. Nguyen, Mallory A. Turner, Christopher Y. Chen, K. Cupelli, V. Reddy, T. Stehle, M. Liszewski, J. Atkinson, M. Barry   +13 more
semanticscholar   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

The Tetraspanin Protein CD9 Modulates Infection with Human Herpesvirus 6A and 6B in a CD46-Dependent Manner

Journal of Virology, 2021
The mechanisms of entry of HHV-6A and HHV-6B into host cells are of significance in order to develop novel drugs that may inhibit infection. To elucidate the contributions of the membrane proteins CD9 and CD46, we employed a genetic approach that ...
Vivien R. Schack, L. Rossen, Clara Christina Ekebjærg, K. Thuesen, B. Bundgaard, P. Höllsberg   +5 more
semanticscholar   +1 more source

Alteration in innate immune cues assessed by analyzing peripheral blood immune system in post-covid patients

Инфекция и иммунитет, 2023
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to global morbidity and mortality. Some patients fully recover from COVID-19, whereas around 45% subjects suffer from various persistent symptoms (fatigue, cognitive impairment, impaired ...
Maria A. Dobrynina, Aleksandr V. Zurochka, Mariia V. Komelkova, Vladimir A. Zurochka, Evgeny A. Praskurnichiy, Liana V. Ryabova, Alexey P. Sarapultsev   +6 more
doaj   +1 more source

Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The adenovirus capsid protein is built by three main capsomers: hexon, fiber, and penton base. Entry is mediated by fiber proteins anchoring the virus to host cell receptors and is followed by penton base proteins engaging coreceptors ...
B. D. Persson, Lijo John, K. Rafie, M. Strebl, L. Frängsmyr, M. Ballmann, K. Mindler, M. Havenga, A. Lemckert, T. Stehle, L. Carlson, N. Arnberg   +11 more
semanticscholar   +1 more source

Function of complement regulatory proteins in immunity of reproduction: a review

Czech Journal of Animal Science, 2005
Humoral immunity has an important role during the maturation and development of the functional properties of spermatozoa. Spermatozoa may be exposed to antisperm antibodies in semen and in cervical, ovarian follicular and fallopian fluid.
J. Valentovičová, M. Simon, J. Antalíková   +2 more
doaj   +1 more source