Results 121 to 130 of about 221,142 (316)

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Modulation of CD4 and CD8 response to QuantiFERON-TB Plus in patients with active tuberculosis and latent tuberculosis infection followed over time during treatment

International Journal of Mycobacteriology, 2016
Objective/Background: Interferon (IFN)-γ release assays (IGRA) are designed for diagnosing tuberculosis (TB) infection. The new IGRA, QuantiFERON-TB Plus (QFT-Plus), is based on the enzyme-linked immunosorbent assay detection of IFN-γ after stimulation ...
Teresa Chiacchio, Elisa Petruccioli, Ilaria Pepponi, Valentina Vanini, Gina Gualano, Daniela Cirillo, Fabrizio Palmieri, Giuseppe Ippolito, Delia Goletti   +8 more
doaj   +1 more source

Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy

, 2011
Includes abstract.Includes bibliographical references (leaves 170-210).Human immunodeficiency virus (HIV) infected children are at greater risk of developing tuberculosis disease, and might benefit from vaccination with novel TB vaccines. However, little
Tena-Coki, Nontobeko Gwendoline
core  

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses

Nature Communications, 2017
Antigen presentation is generally considered the domain of innate immune cells, but CD4+ T cells can transphagocytose bacteria from infected dendritic cells.
Aránzazu Cruz-Adalia, Guillermo Ramirez-Santiago, Jesús Osuna-Pérez, Mónica Torres-Torresano, Virgina Zorita, Ana Martínez-Riaño, Viola Boccasavia, Aldo Borroto, Gloria Martínez del Hoyo, José María González-Granado, Balbino Alarcón, Francisco Sánchez-Madrid, Esteban Veiga   +12 more
doaj   +1 more source

Immunity to self co-generates regulatory T cells

, 2008
Immune responses to self are kept in check by tolerance mechanisms, including suppression by regulatory T cells (Tregs). The defective generation of Tregs specific for self-antigens may lead to autoimmune disease.
Kent P. Jensen, Spiros Fourlanos, James A. Dromey, Stuart I. Mannering, Helen E. Young, Daniel J. Thearle, Bo Han Lee, Leonard C. Harrison, Larissa Belov   +8 more
core  

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Tumor Rejection Effects of Allorestricted Tumor Peptide-Specific CD4 T Cells on Human Cervical Cancer Cell Xenograft in Nude Mice

Cell Transplantation, 2012
Generation of tumor specific alloreactive CD4 + T cells is important to circumvent tumor tolerance. Here, we generate allorestricted peptide-specific CD4 + T cells by coculture of lymphocytes and autologous monocytes bearing allogeneic HLA-DR15 molecule ...
Yinhong Song, Wei Sun, Xiufang Weng, Zhihui Liang, Qian Yu, Zhigang Wang, Lichen Ouyang, Jun Chen, Xiaolin Wu, Guanxin Shen, Xiongwen Wu   +10 more
doaj   +1 more source

Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis

, 2010
Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is ...
Gideon, Hannah Priyadarshini
core  

Exposure to Abnormal Self Antigens During Non-Malignant Inflammatory Events Provides Immunological Defense Against Tumors [PDF]

, 2013
Cancer immunosurveillance is the body’s sentinel mechanism of recognizing and eliminating malignancy. Specifically, the immune system can mount a response against cancer through the recognition of tumor associated antigens (TAA). While studying two TAAs,
Iheagwara, Uzoma
core