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The Role of CD4 Antigen in HIV Infection
1989Ever since the initial description of acquired immune deficiency syndrome (AIDS), it has been known that a specific depletion of CD4+ T-lymphocytes in the peripheral blood accompanies the onset of immunodeficiency (Gottlieb et al 1981). Following the discovery of HIV-1, Klatzmann et al (1984a) showed that the virus had a distinct tropism for and ...
R. A. Weiss +2 more
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Antigen-Induced T Cell Death Is Regulated by CD4 Expression
International Reviews of Immunology, 2001Activation induced cell death (AICD) is a major physiologic pathway that regulates T cell homeostasis. In CD4 T cells, AICD is mediated mainly through Fas/FasL interactions. Although TCR occupancy triggers AICD, the contribution of its tightly associated CD4 coreceptor to the process that leads to AICD is not known. Here we show that CD4 molecule plays
A R, Hamad, J P, Schneck
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CD4 T cells target colorectal cancer antigens upregulated by oxaliplatin
International Journal of Cancer, 2019Immune checkpoint blockade has proven its efficacy in hypermutated subtypes of metastatic colorectal cancers (mCRC). Immunogenic potential can also be observed with conventional chemotherapies, but this property has never been explored thoroughly in CRC patients.
Jeanne Galaine +14 more
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Human CD4 “internal antigen” mimicry by anti-idiotypic monoclonal antibodies
International Journal of Clinical & Laboratory Research, 1994Of 1019 hybridomas generated from a BALB/c mouse immunized with the syngeneic anti-CD4 monoclonal antibody HP2/6, 3 were found to secrete anti-idiotypic antibodies. Detailed analysis of anti-idiotypic monoclonal antibodies F16-10F6, F16-14D6 and F16-16D7 showed they recognize idiotope(s) not expressed by any of the anti-CD4 monoclonal antibodies tested,
F, Perosa, F, Dammacco
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Tracking Antigen Specific CD4+ T-Cells With Soluble MHC Molecules
2007The advent of soluble MHC multimer technology has allowed for the flow-cytometric direct identification of specific-MHC restricted antigen-specific T cells in mixed cell populations and also enabled the direct phenotyping and cloning of these cells at the same time.
John A, Gebe, William W, Kwok
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Molecular basis of T lymphocyte CD4 antigen functions.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1997The T cell surface antigen CD4 plays a pivotal role in the MHC class II-restricted response of specific T lymphocytes and serves as the major receptor of human immunodeficiency viruses (HIV). Recent studies have shown the high complexity of CD4 functions in physiological and pathological conditions.
M, Gaubin +5 more
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Antigen processing for presentation to CD4+ T cells.
The New biologist, 1992The immune system surveys the organism for the presence of foreign or abnormal structures. An important role in the immune response is assumed by T lymphocytes that recognize foreign antigen while tolerating self-proteins. T lymphocytes can recognize only peptide fragments that are presented to them by molecules of the major histocompatibility complex (
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CD4+ T CELL RESPONSES TO EBV NUCLEAR ANTIGENS
Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology, 1997M. V. Lemas +8 more
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