Results 51 to 60 of about 310,362 (291)

Enhancement of tumour-specific immune responses in vivo by 'MHC loading-enhancer' (MLE). [PDF]

PLoS ONE, 2009
BACKGROUND:Class II MHC molecules (MHC II) are cell surface receptors displaying short protein fragments for the surveillance by CD4+ T cells. Antigens therefore have to be loaded onto this receptor in order to induce productive immune responses.
Katharina Dickhaut, Sabine Hoepner, Jamina Eckhard, Karl-Heinz Wiesmueller, Luise Schindler, Guenther Jung, Kirsten Falk, Olaf Roetzschke   +7 more
doaj   +1 more source

Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis

Pathogens, 2023
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of pediatric morbidity and mortality. Young children are at high risk of TB following Mtb exposure, and this vulnerability is secondary to insufficient host immunity ...
Erin Morrow, Qijia Liu, Sarah Kiguli, Gwendolyn Swarbrick, Mary Nsereko, Megan D. Null, Meghan Cansler, Harriet Mayanja-Kizza, W. Henry Boom, Phalkun Chheng, Melissa R. Nyendak, David M. Lewinsohn, Deborah A. Lewinsohn, Christina L. Lancioni   +13 more
doaj   +1 more source

Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells [PDF]

Blood, 2015
Key PointsEpitopes in antigen-armed antibodies that target B-cell receptors are efficiently presented by B lymphoma cells to cytotoxic CD4+ T cells. Memory T cells activated by AgAbs ex vivo are able to kill targeted B lymphoma cells.
Yu, X., Ilecka, M., Bartlett, E.J., Schneidt, V., Bhat, R., Mautner, J., Feederle, R., Delecluse, H.J.   +7 more
openaire   +3 more sources

Expression of CCR6 on Helicobacter pylori-specific circulating CD4+ T cells

Инфекция и иммунитет
Introduction. Helicobacter pylori can infect human gastric mucosa and cause various pathological conditions. In the blood of H. pylori-infected patients, the level of mature CD4+CCR6+ T-lymphocytes, especially pro-inflammatory CCR6+ T-helper types 1 and ...
Vladimir Yu. Talayev, I. Ye. Zaichenko, M. V. Svetlova, E. V. Voronina, O. N. Babaykina, N. V. Neumoina, K. M. Perfilova   +6 more
doaj   +1 more source

Antigen-Dependent and Antigen-Independent Pathways Modulate CD4 ⁺ CD28 ^null T-Cells During Atherosclerosis [PDF]

Circulation Research, 2012
To the Editor: We read with interest the article by Dumitriu et al1 that characterized the alternative costimulatory pathways of CD4+CD28null T cells, a terminally differentiated effector T-cell population, in patients with acute coronary syndromes (ACS).
E. Ammirati, C. Monaco, G.D. Norata
openaire   +5 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development. [PDF]

, 2012
Brucella spp., are Gram negative bacteria that cause disease by growing within monocyte/macrophage lineage cells. Clinical manifestations of brucellosis are immune mediated, not due to bacterial virulence factors.
Alessandro eSette, Anthony P Cannella, Eduardo eGotuzzo, Joseph M Vinetz, Joseph M Vinetz, Li eLiang, Mayuko eSaito, Philip eFelgner, Renee M Tsolis   +8 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Neoantigen-specific T cell help outperforms non-specific help in multi-antigen DNA vaccination against cancer

Molecular Therapy: Oncology
CD4+ T helper antigens are essential components of cancer vaccines, but the relevance of the source of these MHC class II-restricted antigens remains underexplored. To compare the effectiveness of tumor-specific versus tumor-unrelated helper antigens, we
Joanna Fréderique de Graaf, Tamara Pesic, Felicia S. Spitzer, Koen Oosterhuis, Marcel G.M. Camps, Iris Zoutendijk, Bram Teunisse, Wahwah Zhu, Tsolere Arakelian, Gerben C. Zondag, Ramon Arens, Jeroen van Bergen, Ferry Ossendorp   +12 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source