Causal association between blood immune cells and chronic hepatitis B: Univariable and multivariable Mendelian randomization. [PDF]
Medicine (Baltimore)Dong J, Peng Z, Qin C, Shi T.
europepmc +1 more source
Advanced Science, EarlyView.Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang +12 more
wiley +1 more source
Immune cell signatures and preeclampsia: Unveiling causal links through genome-wide association studies. [PDF]
Medicine (Baltimore)Zhang H, Zu Y, Xiu X, Yi H, Xu X, Yan J.
europepmc +1 more source
Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity
Advanced Science, EarlyView.TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao +14 more
wiley +1 more source
Clinical analysis of the onset characteristics and inducing factors of atypical renal tuberculosis. [PDF]
BMC Infect DisLi C, Liu J, Zhu G, Wang Q, Li W.
europepmc +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, EarlyView.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Advanced Science, EarlyView.We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren +6 more
wiley +1 more source
The predictive value of circulating lymphocyte subpopulation characteristics for the prognosis of patients with stage III-IV non-small cell lung cancer treated with EGFR-TKI. [PDF]
Biomed Eng OnlineHan B, Han Y, Zhang Q, Liang L, Jin J.
europepmc +1 more source
Disentangling Coincident Cell Events Using Deep Transfer Learning and Compressive Sensing
Advanced Intelligent Systems, EarlyView.Overlapping cells during detection distort single‐cell measurements and reduce diagnostic accuracy. A hybrid framework combining a fully convolutional neural network with compressive sensing to disentangle overlapping signals directly from raw time‐series data is presented.
Moritz Leuthner +2 more
wiley +1 more source